Neuroinflammation is an important driving mechanism in all diseases caused by frontotemporal lobar degeneration, and predicts clinical progression. Read more
Multiple sclerosis (MS) is a devastating neurological condition affecting millions worldwide. Cognitive impairment significantly impacts the quality of life of people with MS and is often irreversible. Read more
Mitochondrial diseases are caused by defects in genes required for energy production and oxidative phosphorylation (OxPhos). We find it intriguing that some patients with mitochondrial disease present late in life, with very tissue-specific phenotypes. Read more
It is now well established that both gastrointestinal dysfunction and immune activation occur in early Parkinson’s disease, and emerging evidence indicates that these processes are linked to faster disease progression. Read more
The invasive behaviour of glioblastomas (the commonest, most malignant primary brain tumour) means that local treatments won’t cure these tumours, and this diffuse invasion means that there is a disruption of normal cognitive structures. Read more
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