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We have 51 next generation sequencing PhD Projects, Programmes & Scholarships
next generation sequencing PhD Projects, Programmes & Scholarships
We have 51 next generation sequencing PhD Projects, Programmes & Scholarships
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Using multidisciplinary approaches to understand and develop treatments for neurodevelopmental disorders. MRC GW4 BioMed DTP PhD studentship 2024/25 Entry, PhD in Clinical and Biomedical Sciences.
About the GW4 BioMed2 Doctoral Training Partnership. The partnership brings together the Universities of Bath, Bristol, Cardiff (lead) and Exeter to develop the next generation of biomedical researchers. Read more
Unravelling the effects of mitochondrial replacement therapy on mtDNA transmission
Commercial partner: Juno Genetics. Normal oocytes contain ~100,000 copies of mtDNA, which are effectively identical. Patients with mtDNA disease may harbour both mutant and normal mtDNA (heteroplasmy). Read more
Deciphering a novel anti-ageing epigenetic programme
Over two decades of intense research in the field of epigenetics have produced compelling evidence that chromatin modifications are crucial for processes such as DNA repair, transcription, splicing, mitosis, meiosis, and in the preservation of the epigenetic memory of cells. Read more
Haematology: Oncogenic mechanisms causing malignant transformation of B cells and plasma cells
Cancers of B cells and plasma cells, lymphomas and multiple myeloma, can be very aggressive, and often the cancer rapidly reoccurs after standard therapy. Read more
Exploring molecular mechanisms of drug resistance and pathogenicity in the filamentous fungus Aspergillus fumigatus
A. fumigatus is the primary etiological agent of invasive aspergillosis, a disease that primarily affects individuals who are immunocompromised, and causes 200k life threatening infections annually. Read more
Decoding the epigenetic mechanisms of drug resistance in aggressive breast cancers
Breast cancers pose a major health burden to modern world as being the most common cancer in women. Estrogen receptor (ER), the classical marker of 70% these cancers, is the nuclear receptor important for cancer progression. Read more
Identification and modification of the cellular and molecular mechanisms underlying unsuccessful knee replacements for osteoarthritis (NDORMS 2024/11)
Knee osteoarthritis (OA) is the most common form of arthritis, affecting 5.4 million people in the UK. It is characterised by loss of cartilage and inflammation and fibrosis of the synovial tissue that surrounds the joint. Read more
Using statistical and functional analysis to investigate the contrasting disease specific roles of IL6R and the chr17q12 locus in the development of rheumatoid arthritis and asthma
The Arthritis Research UK and Respiratory Centres at the University of Manchester have extensive research programmes investigating the genetic components of rheumatoid arthritis (RA) and asthma. Read more
Molecular analysis of the antimicrobial effects of epoxy-tiglianes on in vitro dysregulation of bacterial biofilms and in vivo wound biofilm disruption
The Advanced Therapies Group at Cardiff University have a BBSRC/NBIC (National Biofilms Innovation Centre) PhD studentship focused on designing and delivering improvement in the ability to effectively treat multi-drug resistant bacterial biofilms. Read more
MSc by Research: Deciphering underlying pathways and impact on LRRK2 signalling network in hereditary Parkinson’s disease
Parkinson’s disease (PD) is a common neurodegenerative condition with no cure and complex aetiology. Around 5-10% a PD cases can be attributed to a monogenetic cause, including LRRK2, while for another ~ 10% of familial cases, the underlying genetic causes have yet to be identified. Read more
How GABA neurones in the DVC control glucose metabolism
The Dorsal Vagal Complex (DVC) of the brain is an important regulator of glucose metabolism and food intake. The Nucleus of the Solitary Tract (NTS) in the DVC senses insulin and triggers a neuronal relay to decrease hepatic glucose production (HPG) in rodents. Read more
Unravelling neurodevelopmental disease mechanisms of developmental delay: Additional sex combs as a model for ASXL-related disorders in the fly
Drosophila melanogaster is a fruit fly species that has been used in research for many years and are a successful model due to their superlative genetics, vast array of tools, a simple genome that is easy to alter, and the fact that 75% of human disease genes have a recognisable orthologue within flies. Read more
Cell biology and evolution of cancer metastasis
We are interested in the spread of cancer, a process called metastasis. Metastasis is responsible for the majority of cancer deaths and there are currently no effective treatments to stop this process. Read more
White Rose BBSRC DTP: Comparison of the DNA recognition and genome packaging mechanisms used by true viruses and novel selfless viruses
Viruses are the most abundant biological agents on our planet, infecting organisms across all domains of life. They affect humans directly through infectious diseases, as well indirectly through their impact on the biosphere. Read more
Fully-funded White Rose BBSRC DTP Biology project: Comparison of the DNA recognition and genome packaging mechanisms used by true viruses and novel selfless viruses
Lead supervisor. Dr Paul Fogg. Co-supervisors. Prof Fred Antson. The student will be registered with the Department of Biology. Viruses are the most abundant biological agents on our planet, infecting organisms across all domains of life. Read more
