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next generation sequencing PhD Projects, Programs & Scholarships

We have 63 next generation sequencing PhD Projects, Programs & Scholarships

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  Precision Medicine DTP: Time-resolved single-cell analysis of neural cell differentiation in motor neuron disease (MND)
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr C Sibley, Dr R Grima
Application Deadline: 1 June 2020

Funding Type

PhD Type

Industrial Partner. Dolomite Bio. Background. Motor neuron disease (MND) is a relentlessly progressing and devastating condition caused by the selective degeneration of upper and lower motor neurons essential for all movement.
  Deciphering a novel anti-ageing epigenetic programme
  Dr G Poulin, Prof A Sharrocks
Applications accepted all year round

Funding Type

PhD Type

Over two decades of intense research in the field of epigenetics have produced compelling evidence that chromatin modifications are crucial for processes such as DNA repair, transcription, splicing, mitosis, meiosis, and in the preservation of the epigenetic memory of cells.
  Exploring molecular mechanisms of drug resistance and pathogenicity in the filamentous fungus Aspergillus fumigatus
  Dr M Bromley, Prof P Bowyer
Applications accepted all year round

Funding Type

PhD Type

A. fumigatus is the primary etiological agent of invasive aspergillosis, a disease that primarily affects individuals who are immunocompromised, and causes 200k life threatening infections annually.
  The respiratory metagenome during exacerbations of asthma
  Prof N Papadopoulos, Prof D Robertson, Dr S Megremis
Applications accepted all year round

Funding Type

PhD Type

Asthma is an international pandemic, with 10% or more of the global population having experience asthma symptoms some time in life.
  Novel non-coding RNAs in Drug response, DNA Damage and Aging
  Dr A Kanhere
Applications accepted all year round

Funding Type

PhD Type

Background. One of the biggest surprises of human genomic sequencing was the finding that only ~2% of the genome codes for proteins.
  Genome and transcriptome sequencing and functional analysis to find new mutation types in patients with inherited blindness
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Human inherited retinal dystrophies (IRDs) result from mutations in over 200 different genes, many of them first implicated by the Leeds Vision Research Group (eg Panagiotou E et al 2017, AJHG 100:960-968; El-Asrag M et al 2015, 96:948-54).
  Listeria monocytogenes in food supply chains – the persistent pathogen (Ref: SF20/APP/FOX)
  Dr E Fox
Applications accepted all year round

Funding Type

PhD Type

The foodborne pathogen Listeria monocytogenes is an important contaminant of food products and associated supply chains, and has caused significant outbreaks of disease through consumption of contaminated food products.
  Analytic methods for detecting and making sense of somatic genomic rearrangements
  Prof A Papenfuss
Applications accepted all year round

Funding Type

PhD Type

Bioinformatics is the application of mathematics, statistics and computational methods to the analysis of molecular biology data.
  Integrated analysis of the Intra-tumour Heterogeneity of Oral squamous cell carcinoma
  Dr I Sequeira
Applications accepted all year round

Funding Type

PhD Type

Cancer is a heterogeneous disease with unique genomic and phenotypic features that differ between individual patients and among different regions within the same tumour.
  The role mRNA-specific translation during chronological aging
  Prof C M Grant, Prof M Ashe, Prof S Hubbard
Applications accepted all year round

Funding Type

PhD Type

Biological ageing can be thought of as a progressive decline in the ability of an organism to survive stress and disease. It is a complex process which is influenced by both genetic and environmental factors.
  Using statistical and functional analysis to investigate the contrasting disease specific roles of IL6R and the chr17q12 locus in the development of rheumatoid arthritis and asthma
  Dr J Curtin, Prof A Simpson
Applications accepted all year round

Funding Type

PhD Type

The Arthritis Research UK and Respiratory Centres at the University of Manchester have extensive research programmes investigating the genetic components of rheumatoid arthritis (RA) and asthma.
  How can epigenetic changes be used to predict and prevent cancer?
  Dr A Chatterjee, Dr E Rodger
Applications accepted all year round

Funding Type

PhD Type

Our lab, led by international leader in epigenetics Dr Aniruddha Chatterjee, combines cutting edge next-generation sequencing, computational analysis, and experimental work to decipher the role of epigenetic modifications and cellular phenotype in cancer.
  De Novo Mutations and Human Disease
  Prof A Goriely, Prof A Wilkie
Application Deadline: 24 July 2020

Funding Type

PhD Type

De novo mutations (DNMs) are a significant contributor to human disease, affecting ~1:300 new births. We study the mechanisms by which these spontaneous mutations arise in the first instance, concentrating on the tissue where most of them originate, the human testis.
  De Novo Mutations and Human Disease
  Prof A Goriely, Prof A Wilkie
Application Deadline: 24 July 2020

Funding Type

PhD Type

De novo mutations (DNMs) are a significant contributor to human disease, affecting ~1:300 new births. We study the mechanisms by which these spontaneous mutations arise in the first instance, concentrating on the tissue where most of them originate, the human testis.
  Uncovering the molecular basis of cellular memory in clonal plants
  Dr J Gutierrez-Marcos, Prof L Frigerio
Application Deadline: 7 June 2020

Funding Type

PhD Type

Compared to animals, somatic cells of plants can be much more easily reprogrammed to regenerate whole new organs and, sometimes, entire individuals.
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