P53 is the most mutated gene in human cancer, affecting about half the cases of human cancer. We have recently identified novel regulators of mutant p53 using sophisticated loss of function whole genome high through put screen (image 1).
In collaboration with Warwick and Birmingham Universities, as well as with the School of Pharmacy and Physics at the University of Nottingham, the Centre for Additive Manufacturing (CfAM) http://www.nottingham.ac.uk/research/groups/cfam are exploring the new area of multi-material, multifunctional Additive Manufacturing through the recently awarded EPSRC Programme Grant.
Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses.
The projection that within 50 years there will be more deaths from antimicrobial resistance than through cancer highlights the continual need for mining new and novel antimicrobials with activity against planktonic microbes and biofilms alike1.