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We have 4 oligonucleotide PhD Projects, Programmes & Scholarships

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oligonucleotide PhD Projects, Programmes & Scholarships

We have 4 oligonucleotide PhD Projects, Programmes & Scholarships

Developing an ADAR-mediated RNA editing therapy for treatment of Duchenne Muscular Dystrophy

Duchenne muscular dystrophy (DMD) is a severe X-linked genetic disorder affecting 1:5000 boys at birth (1). DMD is caused by mutations in Dystrophin gene, with around 10% of the cases caused by nonsense mutations (2,3). Read more

Chemically Modified Therapeutic Nucleic Acids for Neurological Diseases

Therapeutic oligonucleotides are unique in targeting mRNA particularly those that cannot be addressed by conventional small molecule drugs or therapeutic antibodies, their potential is growing fast. Read more

Using microRNA inhibitors to boost GABAergic inhibition as a genetic therapy for epilepsy

Epilepsy is a chronic neurological disease characterised by recurrent spontaneous seizures and cognitive co-morbidities. Current small molecule approaches to treating epilepsy are ineffective in a significant portion of cases, and are associated with substantial adverse effects. Read more
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