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We have 3 oligonucleotide PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
oligonucleotide PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 3 oligonucleotide PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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What is the mechanistic link between mitochondrial dysfunction and protein aggregation; a biochemistry and imaging study
Background. Mitochondrial dysfunction is a key pathogenic mechanism in multiple neurodegenerative diseases, including Parkinson’s Disease; with evidence from both sporadic and familial patient groups and multiple animal models. Read more
New chemistry to enhance splice-switching oligonucleotides
Supervisory Team: Dr Ysobel Baker, Prof Diana Baralle and Prof Eugen Stulz. Project description. We are seeking a highly motivated individual to join our team as a fully funded PhD student developing new chemical modifications to improve the potency of splice-switching oligonucleotides. Read more
Investigating the role of SOD1 in sporadic Motor Neuron Disease patients using structural proteomics
Background. Motor Neuron Disease/Amyotrophic lateral sclerosis (ALS) is a complex neurological disorder characterised by the progressive degeneration of motor neurons that is thought to be caused by mitochondrial dysfunction leading to oxidative stress and neuroinflammation. Read more
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