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We have 18 organoid PhD Projects, Programmes & Scholarships

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organoid PhD Projects, Programmes & Scholarships

We have 18 organoid PhD Projects, Programmes & Scholarships

Vascularisation of tumour organoids for mechanistic and drug development

Gliomas such as are the most common form of brain tumour, a subset Glioblastoma (GBM) are devastating adult brain cancer with high rates of recurrence and treatment resistance. Read more

Investigating mechanisms of extra-cellular matrix remodelling and fibrosis in the gastrointestinal tract

Inflammatory bowel diseases, such as Crohn's disease, are increasing in prevalence globally. These are caused by chronic inflammation in the gut, there is no cure and medications are not effective for all. Read more

Creating patient-specific retinal organoids from human induced pluripotent stem cells for in vitro simulation of uveitis

Uveitis, although uncommon, is a notable cause of visual impairment and blindness. Uveitis encompasses a range of conditions driven by both innate autoinflammatory and adaptive autoimmune CD4 T-cell responses. Read more

Uncovering the role of RARɣ in mouse embryonic development using gastruloids

The three retinoic acid receptors (RAR), RARα, RARβ, RARɣ, are transcription factors that control gene expression and cell fate following their activation by all-trans retinoic acid (ATRA), the active metabolite of vitamin A. Read more

Uncovering the mechanochemical signalling inputs that drive gastruloid axial patterning

How the early mammalian embryo converts a mass of identical cells in an organism with multiple axes of symmetry (anteroposterior, dorsoventral, mediolateral) is a critical question in developmental biology. Read more

Bioengineering a dynamic culture platform to improve the maturity of iPSC-derived muscle organoids

About the project. Heart disease is a critical health burden and leading cause of mortality worldwide. To understand disease mechanisms and develop future treatments for heart disease, we have developed a human cardiac organoid platform derived from pluripotent stem cells. Read more

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