Vertebral fractures (VFs) in adults over 50 years lead to reduced quality life, increased mortality and are strongly associated with osteoporosis and the risk of further fractures. Read more
Traditionally, randomised controlled trials in cancer have focussed predominantly on overall survival (OS) and progression free survival (PFS) as the main outcomes of interest and primary drivers or interpretation. Read more
This full-time DPhil post at the Botnar Institute will use cutting edge laboratory and computational methods to interrogate the mechanisms underlying failed repair following scaphoid fracture. Read more
This full-time DPhil post at the Botnar Institute will use cutting edge laboratory and computational methods to interrogate the mechanisms underlying shoulder pain. Read more
Patient-reported outcomes are included in randomised clinical trials (RCTs) as primary or secondary endpoints to measure the impact of interventions and are increasingly recognised by regulators, clinicians, and patients as valuable tools that ensure comprehensive assessment. Read more
This DPhil in Clinical Epidemiology and Medical Statistics will include a 3-year project focussing on target trial emulation studies to generate real-world evidence for arthritis and orthopaedic treatments using de-identified, routinely-collected data from primary and secondary care in the UK and across Europe. Read more
Fibrotic diseases affect multiple organ systems, increasing global morbidity and mortality1. Fibrosis is the final common pathway for a wide range of diseases affecting joint soft tissues including tendons, ligaments and synovial tissues2,3. Read more
Fibrotic diseases affect multiple organ systems, increasing global morbidity and mortality1. Fibrosis is a final common pathway for a wide range of diseases affecting musculoskeletal tissues. Read more
This DPhil project aims to elucidate the mechanisms of RNA splicing within immune cells, focusing on the computational analysis of alternative splicing events and their impact on immune homeostasis and inflammatory responses. Read more
Adverse drug reactions (ADRs) are unintended, harmful events attributed to the use of medicines. In modern healthcare, ADRs pose a significant challenge due to the complexity of therapeutics, an aging population, and rising multimorbidity. Read more
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