Defining the role of p53 in cancer immunotherapy
Prof Y. Haupt, Dr S. Haupt, Dr P. Neeson
Applications accepted all year round
Despite clear evidence of an association between the tumour suppressor p53 and immunity, a gap in knowledge exists regarding its role in modulating immune responses, or its value in predicting patient responses to immunotherapy.
Exploring the boundaries of the human acetylome
Dr S Cowley, Prof D Panne
6 January 2019
Lysine acetylation (Lys-Ac) is an abundant post-translational modification (PTM) occurring on thousands of proteins. However, our understanding of ‘acetylome’ regulation and its functional consequences remains well behind other common PTMs such as phosphorylation and ubiquitination.
Molecular imaging of DNA damage repair
Dr B Cornelissen, Prof N Sibson
11 January 2019
The Laboratory for Radiopharmacy and Molecular Imaging focuses on the development of radiolabelled molecular imaging agents for oncology.