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p53 PhD Projects, Programs & Scholarships

We have 7 p53 PhD Projects, Programs & Scholarships

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  Exploration of novel approaches to anti-cancer treatment: manipulation of mutant p53
  Prof Y. Haupt, Dr S. Haupt
Applications accepted all year round
P53 is the most mutated gene in human cancer, affecting about half the cases of human cancer. We have recently identified novel regulators of mutant p53 using sophisticated loss of function whole genome high through put screen (image 1).
  Defining the role of p53 in cancer immunotherapy
  Prof Y. Haupt, Dr S. Haupt, Dr P. Neeson
Applications accepted all year round
Despite clear evidence of an association between the tumour suppressor p53 and immunity, a gap in knowledge exists regarding its role in modulating immune responses, or its value in predicting patient responses to immunotherapy.
  The DNA Damage Response in Cancer
  Dr G Melino, Dr I Amelio
Application Deadline: 28 June 2019
The MRC Toxicology Unit is a leading international research institute within the School of Biological Sciences in the University of Cambridge.
  Repairing DNA Damage in Response to BRAF Mutation
  Dr C McCabe, Prof G Stewart
Applications accepted all year round
We are the leading thyroid cancer research group in the UK; we work on other neoplasias as well, including breast and head and neck etc.
  Developing precision medicines for B-cell leukaemias and lymphomas
  Dr S Macip, Prof M J S Dyer
Applications accepted all year round
In this project, we propose to look for novel therapies for B-cell leukaemias and lymphomas in a translational and mechanistic fashion.
  Exploring the boundaries of the human acetylome
  Dr S Cowley, Prof D Panne
Application Deadline: 5 May 2019
Lysine acetylation (Lys-Ac) is an abundant post-translational modification (PTM) occurring on thousands of proteins. However, our understanding of ‘acetylome’ regulation and its functional consequences remains well behind other common PTMs such as phosphorylation and ubiquitination.
  Structural mechanism of signal-dependent gene transcription
  Prof D Panne, Dr A Revyakin
Application Deadline: 5 May 2019
The control of gene transcription is one of the main regulatory steps for cellular gene regulation.
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