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p53 PhD Projects, Programs & Scholarships

We have 8 p53 PhD Projects, Programs & Scholarships

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Showing 1 to 8 of 8
  Exploration of novel approaches to anti-cancer treatment: manipulation of mutant p53
  Prof Y. Haupt, Dr S. Haupt
Applications accepted all year round
P53 is the most mutated gene in human cancer, affecting about half the cases of human cancer. We have recently identified novel regulators of mutant p53 using sophisticated loss of function whole genome high through put screen (image 1).
  Defining the role of p53 in cancer immunotherapy
  Prof Y. Haupt, Dr S. Haupt, Dr P. Neeson
Applications accepted all year round
Despite clear evidence of an association between the tumour suppressor p53 and immunity, a gap in knowledge exists regarding its role in modulating immune responses, or its value in predicting patient responses to immunotherapy.
  Characterisation of cell death mechanisms in cancer: protein interactions in p53/PERP-mediated apoptosis
  Prof L Paraoan, Dr I Prior
Applications accepted all year round
Apoptosis or programmed cell death is a tightly regulated intrinsic process of programmed cell death used by cells in all multicellular organisms, including humans, to control tissue homeostasis or to initiate their own death following malfunction or damage beyond repair.
  Regulation of ribosome modification as a means to enhance anti-fungal antibiotic efficacy
  Dr N Watkins
Application Deadline: 11 January 2019
10-20% of worldwide food, from reduced harvest and post-harvest food spoilage, is lost due to fungal contamination. Food loss is due to contamination with mycotoxins such as aflatoxins, which are potent carcinogens and cause severe liver damage.
  Developing precision medicines for B-cell leukaemias and lymphomas
  Dr S Macip, Prof M J S Dyer
Applications accepted all year round
In this project, we propose to look for novel therapies for B-cell leukaemias and lymphomas in a translational and mechanistic fashion.
  Exploring the boundaries of the human acetylome
  Dr S Cowley, Prof D Panne
Application Deadline: 6 January 2019
Lysine acetylation (Lys-Ac) is an abundant post-translational modification (PTM) occurring on thousands of proteins. However, our understanding of ‘acetylome’ regulation and its functional consequences remains well behind other common PTMs such as phosphorylation and ubiquitination.
  Structural mechanism of signal-dependent gene transcription
  Prof D Panne, Dr A Revyakin
Application Deadline: 6 January 2019
The control of gene transcription is one of the main regulatory steps for cellular gene regulation.
  Molecular imaging of DNA damage repair
  Dr B Cornelissen, Prof N Sibson
Application Deadline: 11 January 2019
The Laboratory for Radiopharmacy and Molecular Imaging focuses on the development of radiolabelled molecular imaging agents for oncology.
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