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patch clamp PhD Projects, Programmes & Scholarships
We have 19 patch clamp PhD Projects, Programmes & Scholarships
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THE CELLULAR ORIGIN OF SPATIAL DIFFERENCES FOR THE MATURATION OF LIGHT RESPONSES (ref: SF22/HLS/APP/HILGEN)
Vision is probably our most important sense. Vision starts in the retina, the light-sensitive tissue lining the back of the eye. It is a well-layered structure with synaptic (connections of neurons) and nuclear (cell bodies) layers. Read more
Funded PhD - Cannabinoids in the ticking network of the brainstem satiety centre
Life on Earth is subordinate to periodic alterations in the environment, with most notable changes seen from day to night. To react, anticipate, and adapt to these cyclic changes, living organisms evolved endogenous 24h timekeeping mechanisms named circadian clocks. Read more
Pharmacology of ion channels in human genetic disorders
The School of Biomedical Sciences invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2023/24. Read more
MSC BY RESEARCH - Preserving t-tubule function in adult cardiac myocytes in short-term culture
Invaginations of the sarcolemma of adult cardiac myocytes known as transverse (or t-) tubules account for up to 65% of the total sarcolemma surface and play a key role in excitation-contraction (EC) coupling and cell signalling (Hong & Shaw, 2017). Read more
Assessing the Impact of Aggregation-Prone Proteins on the Mitochondrial-Metallome Interplay in a Novel 3D Spheroid Cholinergic Cell Model of Neurodegenerative Disease
Although showing diverse symptoms affecting cognition and movement, the brains of patients with neurodegenerative disorders (NDs) display similar neuropathological features namely protein aggregation within the brain. Read more
Ion channel signalling in cancer cells
Our cells constantly sense and transport ions present in their environment. From embryonic development to epilepsy to heart disease to cancer, our cells’ ability to respond to changes in the ionic microenvironment is essential for healthy ageing. Read more
Develop single-cell biomechanical nanotools for novel cardiovascular mechanobiology and cancer immunotherapy
In view of the high complexity and dynamics of protein complexes that perform important physiological functions, it is difficult to visualise and characterise their kinetic and signaling processes on single living cells using traditional biochemical and biophysical techniques. Read more
Pathophysiology of red cell membrane permeability
Our project investigates how red cell membrane permeability is altered in pathophysiological states. Read more
Stem cells and hungry neurons: neuropeptides in energy homeostasis
Summary. You will investigate the role of neural stem cells and neurons in energy homeostasis. You will determine how neuropeptides and diet affects stem cells, neurons and glia from mouse and human brain. Read more
Natural toxins and their synthetic analogues as tools to study ion channels and as potential drugs and pesticides
The project will use a combination of electrophysiological techniques such as voltage-clamp and patch-clamp with molecular biology and protein expression to understand how natural toxins and their synthetic analogues act on ion channels in the nervous system. Read more
Last chance to apply
PhD studentship - Human iPSC-derived Sensory Neurons to Interrogate the Molecular Interplay between mTORC1 and Histamine Receptors in the Progression of Neuropathic Pain
Overview. Are you interested in exploring novel strategies to alleviate pain responses in patients with chronic pain? This PhD studentship will use stem cell-derived sensory neurons to understand the relationship between mTORC1 and histamine in chronic pain. Read more
Circuit basis of learning and action-selection
The overall goal of our research is to discover the circuit implementation of learning and action selection. Since these functions likely emerge from… Read more
Effects of insecticides on brain activity
Project Overview. Overview . This project is an exciting new collaboration between the University of Reading and Syngenta Group, to investigate the mammalian toxicity of insecticides and understand their effects on the brain. Read more
Combining laser and ultrasound based molecular delivery strategies for enhanced drug delivery
Overview. This project addresses the critical area of delivering therapeutics to the skin. If successful, the approach will have direct and positive consequences for the treatment of a range of skin diseases, but may also be viewed as a more generic means of drug delivery for treating a much wider range of disease. Read more
GW4 BioMed2 MRC DTP PhD project: Opioid overdose deaths: Understanding interactions between benzodiazepines and opioids
This project is one of a number that are in competition for funding from the GW4 BioMed2 MRC Doctoral Training Partnership which is offering up to 20 studentships for entry in September 2024. Read more
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