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patch clamp PhD Projects, Programmes & Scholarships
We have 11 patch clamp PhD Projects, Programmes & Scholarships
Using microRNA inhibitors to boost GABAergic inhibition as a genetic therapy for epilepsy
Epilepsy is a chronic neurological disease characterised by recurrent spontaneous seizures and cognitive co-morbidities. Current small molecule approaches to treating epilepsy are ineffective in a significant portion of cases, and are associated with substantial adverse effects. Read more
How inflammatory macrophages instruct innate effector responses in the tumour microenvironment?
Macrophages instruct the functions of other innate cells to coordinate the type and timing of inflammatory responses. We recently identified CALHM6 as a TLR- and interferon-inducible membrane protein on macrophages, important for macrophage-mediated instruction of early innate responses to infections. Read more
Ion channel signalling in cancer cells
Our cells constantly sense and transport ions present in their environment. From embryonic development to epilepsy to heart disease to cancer, our cells’ ability to respond to changes in the ionic microenvironment is essential for healthy ageing. Read more
Assessing the Impact of Aggregation-Prone Proteins on the Mitochondrial-Metallome Interplay in a Novel 3D Spheroid Cholinergic Cell Model of Neurodegenerative Disease
Although showing diverse symptoms affecting cognition and movement, the brains of patients with neurodegenerative disorders (NDs) display similar neuropathological features namely protein aggregation within the brain. Read more
Investigating Epilepsy Molecular Mechanisms in Patient-Specific Stem Cell Models of SLC6A1 Deficiency
SLC6A1 encodes GAT-1, a voltage-dependent gamma-aminobutyric acid (GABA) transporter that is responsible for the reuptake of GABA from the synapse. Read more
Natural toxins and their synthetic analogues as tools to study ion channels and as potential drugs and pesticides
The project will use a combination of electrophysiological techniques such as voltage-clamp and patch-clamp with molecular biology and protein expression to understand how natural toxins and their synthetic analogues act on ion channels in the nervous system. Read more
GW4 BioMed2 MRC DTP PhD project: Identification of ion channel dysfunction in epilepsy with machine learning
This project is one of a number that are in competition for funding from the GW4 BioMed2 MRC Doctoral Training Partnership which is offering up to 21 studentships for entry in September 2025. Read more
Circuit basis of learning and action-selection in Drosophila
The overall goal of our research is to discover the circuit implementation of learning and action selection. Since these functions likely emerge from… Read more
3D printing spinal cords
Project Overview. This project offers an exciting opportunity to use hydrogels and 3D printing to engineer a segment of the spinal cord, which could be further developed into a transplant for patients with spinal cord injury (SCI). Read more
Model-predictive control of brain plasticity for optimal non-invasive brain stimulation
Neuroplasticity is the mechanism that underpins the brain’s ability to learn or recovery from traumatic events, but also its deterioration underlies several Neurodegenerative diseases and mental illnesses. Read more
Deriving functional neurons from hIPSCs
Neuronal networks grown on petri dishes encode information as electrical activity. This activity is dictated by their underlying structural and functional connectivity. Read more
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