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pathogen PhD Projects, Programmes & Scholarships
We have 71 pathogen PhD Projects, Programmes & Scholarships
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Novel anti-pathogen regulatory mechanisms driven by Human Guanylate Binding Proteins
Human GBPs are a family of seven ~65kDa GTPases whose expression is upregulated by IFNg, for example during an infection. All mammalian GBPs contain a GTPase domain and a C-terminal helical region. Read more
Metals and host-pathogen interactions: the role of metal handling systems in the human gastrointestinal pathogen Campylobacter jejuni
Campylobacter jejuni is a globally important food-borne pathogen causing an estimated 400-500 million cases of acute human gastroenteritis each year. Read more
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Towards new drugs and diagnostics for tuberculosis: Elucidating and exploiting essential pathways in the Mycobacterium tuberculosis pathogen
This project is available through the MIBTP programme. The successful applicant will join the MIBTP cohort and will take part in all of the training offered by the programme. Read more
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Using an interdisciplinary approach to elucidate pollution impacts and antimicrobial resistant pathogen dynamics across terrestrial, estuarine and marine environments
Project Description. The impact of environmental change on pathogen dynamics and AMR evolution from catchment to coast. Coastal environments are particularly vulnerable to chemical and microbial pollution that impact ecosystem services and human health. Read more
Antibiotic Resistance and Biofilm Formation in Clinical Isolates of Enterococcus faecium – a WHO High Priority Pathogen
E. faecium is an important human pathogen which exhibits resistance to a range of antibiotics, and is implicated in a wide variety of device associated infections. Read more
Understanding the commensal-to-pathogen transition – environmental cues and signalling cascades
Summary. The yeast Candida albicans is a common commensal of the human gastrointestinal tract. Using a combination of microbiology, molecular biology, protein biochemistry and proteomics methods, this project aims to define the role of a Hsp90 phospho-switch . Read more
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Rice farming and rodent-borne zoonoses
Land-use changes due to intensified agricultural practices are a concern in the Philippines (Dirzo et al, 2014). The replacement of forests by mixed agroecosystems and high-value crops has led to biodiversity loss and increased contact of humans with wild animal populations. Read more
Reduced representation of pangenomes for rapid pathogen genomic sequence analysis
Research interests/description of main research theme. In order to better guard against the rapid spread of high-risk strains of infectious diseases in the future, we must better leverage the large scale collection and processing of genomic data that is possible with today’s technologies. Read more
Kmer graph representation of pangenomes for rapid pathogen genomic sequence analysis
In order to improve our defenses against the rapid spread of high-risk strains of infectious diseases in the future, we must better leverage the large scale collection and processing of genomic data that is possible with today’s technologies. Read more
Unlocking the relationship between host metal distribution and pathogen phenotype in tuberculosis
Research Group:
Biochemistry
Mycobacterium tuberculosis (M.tb) is the leading cause of death by a bacterial pathogen, with 1.5 million deaths estimated in 2020. Read more
Nutritional immunity: the battle for iron between host and pathogen
The innate immune defence system responds to bacterial infection by reducing the amount of available iron to restrict bacterial growth. Read more
Disarming antimicrobial responses: how Klebsiella pneumoniae controls inflammasome activation
Microbial infection triggers assembly of inflammasome complexes that promote caspase-1–dependent antimicrobial responses. This project will dissect how the antibiotic resistant pathogen Klebsiella pneumoniae evades inflammasome activation to overcome host restriction during pneumonia. Read more
Targeting the control of antimicrobial efflux in Mycobacterium tuberculosis to combat MDR-TB
We need more drugs for tuberculosis (TB), particularly multi-drug resistant (MDR) TB. TB treatment length (currently up to 24 months) needs to be shortened by using more effective drug combinations. Read more
Role of the stringent response to promote biocide induced antibiotic tolerance in Staphylococcus aureus biofilms.
The selection of antibiotic tolerant bacteria is of emerging concern and is thought to contribute to treatment failure. Our preliminary data supports the hypothesis that widely used biocides can promote such tolerance in the major human pathogen Staphylococcus aureus by activation of the stringent response. Read more
Body-on-a-chip: a novel approach to understanding antimicrobial resistance
Why is this research important? The 2019 World Health Organisation report on antimicrobial resistance (AMR)identifies AMR as one of the greatest threats we face as a global community. Read more