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pathogen PhD Projects, Programmes & Scholarships

We have 71 pathogen PhD Projects, Programmes & Scholarships

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We have 71 pathogen PhD Projects, Programmes & Scholarships

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Novel anti-pathogen regulatory mechanisms driven by Human Guanylate Binding Proteins

Human GBPs are a family of seven ~65kDa GTPases whose expression is upregulated by IFNg, for example during an infection. All mammalian GBPs contain a GTPase domain and a C-terminal helical region. Read more
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Using an interdisciplinary approach to elucidate pollution impacts and antimicrobial resistant pathogen dynamics across terrestrial, estuarine and marine environments

Project Description. The impact of environmental change on pathogen dynamics and AMR evolution from catchment to coast. Coastal environments are particularly vulnerable to chemical and microbial pollution that impact ecosystem services and human health. Read more

Understanding the commensal-to-pathogen transition – environmental cues and signalling cascades

Summary. The yeast Candida albicans is a common commensal of the human gastrointestinal tract. Using a combination of microbiology, molecular biology, protein biochemistry and proteomics methods, this project aims to define the role of a Hsp90 phospho-switch . Read more
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Rice farming and rodent-borne zoonoses

Land-use changes due to intensified agricultural practices are a concern in the Philippines (Dirzo et al, 2014). The replacement of forests by mixed agroecosystems and high-value crops has led to biodiversity loss and increased contact of humans with wild animal populations. Read more

Reduced representation of pangenomes for rapid pathogen genomic sequence analysis

Research interests/description of main research theme. In order to better guard against the rapid spread of high-risk strains of infectious diseases in the future, we must better leverage the large scale collection and processing of genomic data that is possible with today’s technologies. Read more

Kmer graph representation of pangenomes for rapid pathogen genomic sequence analysis

In order to improve our defenses against the rapid spread of high-risk strains of infectious diseases in the future, we must better leverage the large scale collection and processing of genomic data that is possible with today’s technologies. Read more

Disarming antimicrobial responses: how Klebsiella pneumoniae controls inflammasome activation

Microbial infection triggers assembly of inflammasome complexes that promote caspase-1–dependent antimicrobial responses. This project will dissect how the antibiotic resistant pathogen Klebsiella pneumoniae evades inflammasome activation to overcome host restriction during pneumonia. Read more

Targeting the control of antimicrobial efflux in Mycobacterium tuberculosis to combat MDR-TB

We need more drugs for tuberculosis (TB), particularly multi-drug resistant (MDR) TB. TB treatment length (currently up to 24 months) needs to be shortened by using more effective drug combinations. Read more

Role of the stringent response to promote biocide induced antibiotic tolerance in Staphylococcus aureus biofilms.

The selection of antibiotic tolerant bacteria is of emerging concern and is thought to contribute to treatment failure. Our preliminary data supports the hypothesis that widely used biocides can promote such tolerance in the major human pathogen Staphylococcus aureus by activation of the stringent response. Read more

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