People with cystic fibrosis (pwCF) harbour chronic lung infections caused by a variety of bacterial pathogens. In the CF airway, mucus accumulates in the lungs potentiating the development of a taxonomically diverse lung microbiome. Read more
Project ID. HI_10. Theme. Health Innovation. Antimicrobial resistance of bacterial pathogens is of increasing concern, both for human and animal pathogens. Read more
Bacterial pathogens respond rapidly to environmental change, in ways that can influence their growth, virulence, antimicrobial resistance and, therefore, infection outcomes. Read more
Project description. Antimicrobial resistance (AMR) is one of the biggest global challenges to human health in the 21st century, with the worst-case scenario development of a raft of incurable infections, especially Hospital Gram negative pathogens. Read more
Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response. Read more
Research Group:
Astbury Centre for Structural Molecular Biology
Antibiotics make possible the treatment and cure of life-threatening bacterial infections and have added over a decade to average human lifespan. Read more
Project details. Bacterial oral infections can cause a variety of problems including dental caries, abscesses, gingivitis and periodontal disease. Read more
Many species of bacteria use a contractile nanomachine known as the Type VI secretion system (T6SS) to deliver a wide range of toxic proteins, known as ‘effectors’, directly into neighbouring cells. Read more
This project will be undertaken in collaboration with Zoological Society of London and includes a minimum 3-month placement based at the ZSL premises. Read more
This project will be undertaken in collaboration with Zoological Society of London and includes a minimum 3-month placement based at the ZSL premises. Read more
The global burden of fungal infections is now surpassing 7 million annually, with the average mortality rate exceeding that for malaria or breast cancer (Fisher M. Read more
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