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peptide synthesis PhD Projects, Programmes & Scholarships

We have 18 peptide synthesis PhD Projects, Programmes & Scholarships

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We have 18 peptide synthesis PhD Projects, Programmes & Scholarships

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Neuropeptide Research – PhD Position at a World Class Institution

Neuropeptides are key mediators in many biological functions and understanding their interaction with target proteins is fundamental to unravel the underlying mechanism of diseases. Read more

A high-throughput library approach for minimizing peptide off-targets

Supervisors. Louise Walport. Ben Schumann. Martin Münzel (Novo Nordisk). Recent breakthroughs in oral peptide delivery have vastly extended the chemical space which is available to drug protein/protein interactions and other challenging targets. Read more

Biochemical Optimisation of a Male Contraceptive

The development of a reversible and non-hormonal male contraceptive will supplement existing birth control options to achieve a significant impact upon the numbers of unwanted pregnancies, a major global problem. Read more

Microneedle delivery of non-ribosomal antimicrobial peptides to treat multidrug-resistant Gram-negative infections

The increasing prevalence of infections caused by multidrug-resistant (MDR) bacteria is a major global concern, with global deaths due to antimicrobrial resistance expected to hit ten million per year by 2050. Read more

Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

  Research Group: Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more
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Novel Chemoenzymatic Approaches to 'Unnatural' Products

Natural products represent a major source of powerful and innovative therapeutic agents for the treatment of human, animal and plant diseases.1 Many of these products, including broad-spectrum and last resort antibiotics such as erythromycin, vancomycin and taxol are of polyketide, nonribosomal peptide and terpene origin. Read more

Precise, peptide-directed loading of drugs onto therapeutic antibodies for targeted imaging and treatment of tumors.

The PhD project aims to develop a non-covalent technology for loading small molecules and therapeutic enzymes onto monoclonal antibodies thus addressing issues in preparations of antibody-drug conjugates, such as poor yields and non-specific conjugation of the drugs resulting in compromised immunoaffinity. Read more

Unlocking new drug targets through antibody-targeted protein degradation

Supervisors. Professor Ed Tate (ICL). Dr Paul Hogg (ADCT, White City). Dr Francesca Zammarchi (ADCT, White City). Targeting protein degradation with Proteolysis-Targeting Chimeras (PROTACs) is an area of great current interest in drug discovery. Read more

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