Novel cyclic peptide constructs for targeted biomolecular imaging
Prof M Zanda, Dr S Butler
15 February 2019
Over 40 cyclic peptides are used in the clinic for a wide range of applications, such as somatostatin and ciclosporin. Cyclic peptides have enormous potential for disrupting protein-protein interactions and are therefore being pursued as drug candidates for treating a number of unmet medical needs.
Cationic antimicrobial peptides as anticancer agents
Dr R Green, Prof R A Frazier
Applications accepted all year round
Cationic peptides are widespread in nature where they play a key role in host defense within plants and animals. The mechanism by which these peptides interact with cell membranes potentially leads to these being less prone to antimicrobial resistance than conventional antibiotics.
(BBSRC DTP) Inhibition of SR protein kinase 1 with designer peptides
Dr A Golovanov, Dr A Almond
31 January 2019
This PhD project addresses BBSRC’s ENWW in that the student will be trained in. Biophysical techniques - ITC, SPR, CD; Structural biology techniques - solution state NMR and X-ray crystallography; Computational techniques - molecular dynamics simulations and computer modelling and analysis.