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peptides PhD Projects, Programmes & Scholarships
We have 45 peptides PhD Projects, Programmes & Scholarships
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Therapeutic targeting of chemokines in inflammation
Protein interactions underlie most biological processes but are challenging to target using small molecule drugs. Many protein interactions are mediated by short-linear-interacting motifs (SLiMs) that range from 3-12 amino acid residues (1, 2). Read more
Computer simulation of metal-amyloid interaction and its role in plaque formation
Alzheimer’s disease is one of the greatest healthcare challenges facing 21st century society. AD is associated with formation of fibrils and plaques in brain tissue that impair proper functioning of neurons. Read more
Treatment of infections caused by multidrug-resistant Gram-negative infections through microneedle delivery of antimicrobial peptides
Antimicrobial resistance (AMR) is a critical threat to human health and novel antibiotics and treatments are desperately needed to prevent a future pandemic. Read more
Metal-Mediated Modification of Peptides and Proteins
We have shown that robust organometallic complexes can selectively functionalise natural amino acids by targeting nucleophilic residues such as cysteine to provide peptides and proteins with unique structures [1]. Read more
Microneedle delivery of non-ribosomal antimicrobial peptides to treat multidrug-resistant Gram-negative infections
The increasing prevalence of infections caused by multidrug-resistant (MDR) bacteria is a major global concern, with global deaths due to antimicrobrial resistance expected to hit ten million per year by 2050. Read more
Investigation of salivary peptides as SARS-CoV-2 entry inhibitors
The global pandemic caused by the emergence of a novel Coronavirus in Wuhan during 2019 has had a huge impact on all aspects of human health. Read more
Protease-resistant antimicrobial peptides to target bacterial and fungal pathogens
Antimicrobial resistance is quickly becoming a serious global health problem. The emergence of multidrug-resistant microbial strains combined with the drying up of the antibiotic pipeline in the pharmaceutical industry has significantly worsened the situation in recent years. Read more
A non-invasive robotic capsule for oral delivery of peptides and proteins
While significant advances have been made in administrating these biologics through the parental routes, delivering these molecules orally remains a major challenge for pharmaceutical industry. Read more
Chemo-enzymatic Synthesis and Potential Applications of Novel antimicrobial peptides
Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses. Read more
Development of peptide hydrogel as an anticancer drug carrier
Growth in nanotechnologies can now be exploited to enable engineering of new drug delivery systems for enhancing the entrapment of drugs in nano-sized structures with tailored physical properties to suit therapeutic need. Read more
Design and characterisations of novel antimicrobial biomaterials
Self-assembled nanobiomaterials are becoming an important research theme due to their potential in infection control and wound care, gene and cell delivery, biodevices and tissue regeneration. Read more
Biological role of Stress Hormones
OVERVIEW. Our lab focuses on the biological roles of peptide hormones derived from pro-opiomelanocortin (POMC), a protein produced in the anterior pituitary gland. Read more
Drug Development Informatics: a framework to support the analysis of large-scale simulations
Drug resistant infections are already on the rise with numbers suggesting that up to 50,000 lives are lost each year to antibiotic-resistant infections in Europe and the US alone. Read more
Peptide hydrogels as a long-acting multipurpose drug delivery platform for combined contraception and HIV prevention
HIV/AIDS is the leading cause of death in women of reproductive age worldwide. HIV and unintended pregnancies are prevalent in developing nations due to the lack of effective female contraceptive choice. Read more
Nanostructured Self-Assembly of Bio-Derived and Bio-Inspired Lipid-Based Amphiphiles: Synthesis
This exciting research project is associated with an EPSRC Fellowship award to Prof Hamley. This is a 4-year project which also involves two postdoctoral researchers and another PhD studentship. Read more