More people die from fungal infections than from malaria, tuberculosis, or ‘superbugs’ such as MRSA. Candida species are an important group of human fungal pathogens causing over 400,000 life threatening infections per year.
Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response.
Diseases of inflammation contribute to the biggest health problems of the 21st century. Mutli-morbidity, the coincidence of multiple pathologies, is driven by processes such as inflammation and by inflammatory cells like neutrophils.
Macrophages are effector cells that directly kill microbes and regulatory cells that coordinate the wider immune response. Due to the complex nature of macrophage function, how their different roles are integrated during infection and inflammation is still poorly understood.