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We have 7 pharmacokinetics PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
pharmacokinetics PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 7 pharmacokinetics PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Design, synthesis and evaluation of protease-activated anti-cancer prodrugs
Research Group:
Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more
Production of super small nanocrystals for drug delivery to target tissues
The student will be involved in an exciting project related to the design, formulation and in vitro/in vivo characterisation of super small drug nanocrystals with specific surface properties to enhance drug accumulation in target tissues, such as the lymphatic or central nervous systems. Read more
Mechanochemical synthesis of polymer-drug conjugates via reactive extrusion
Polymer–drug conjugate (PDCs) therapeutics are pharmacologically active macromolecular constructs comprising at least one therapeutic agent covalently bound to a polymeric carrier. Read more
A systems biology analysis of thioredoxin reductase inhibition to support discovery of a novel antifungal treatment
Fungal diseases affect approximately 1.2 billion individuals worldwide with at least 1.5 million deaths each year. The emergence of resistant strains made clinical treatment failures more frequent. Read more
Personalising cancer treatment with modelling tumour evolution based on genomics biomarkers and PK/PD
Tumour heterogeneity is a major problem limiting the efficacy of targeted oncological therapies. Most advanced tumours eventually become resistant to the treatments, ultimately making the patient succumb to metastatic disease. Read more
Synthesis of Peptidomimetics Based on Functionalizable Freidinger Lactams
Despite mediating a plethora of vital biological processes in living organisms, peptides remain a challenging class of drug targets due to their poor cell penetration, proteolytic instability and unfavourable pharmacokinetics. Read more
PREDICTING CRYSTALLURIA
Acute Kidney Injury (AKI) is poorly diagnosed, ineffectively managed and has been recognised as a condition of global concern (Lancet. Read more
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