The Laboratory of Stem Cells and Diseases (STEMD-Lab) is seeking a highly motivated candidate to develop a project based on the use of human embryonic stem cells (hES) and induced pluripotent stem cells (iPSCs) to derive glucose sensitive differentiated cell types (i.e.
Project background. Regulation of proteostasis is critical for maintaining tissue homeostasis. Autophagy, a major intracellular degradation pathway essential for cellular and energy homeostasis, functions in the clearance of aggregation-prone proteins and damaged organelles.
Peripheral neuropathies (PNs) affect 2% of the general population. Somatic PNs cause locomotor and sensory deficits, while autonomic PNs cause cardiac dysrhythmias and gastrointestinal and urinary bladder dysfunction.