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pluripotent PhD Projects, Programmes & Scholarships
We have 28 pluripotent PhD Projects, Programmes & Scholarships
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The Roadmap of Human Pluripotency, Living Systems Institute – PhD
In the early mammalian embryo a group of cells form that have the special property of pluripotency. Pluripotency is the developmental potential of a cell to generate the founder lineages of the embryo. Read more
Mechanistic understanding of how Non-Alcoholic Fatty Liver disease (NAFLD) can lead to cardiovascular dysfunction using induced pluripotent stem cell (iPSC) derived cardiomyocytes and hepatocytes.
Background. Liver disease accounts for 3.5% of all global deaths/year (~2 million people) and is the third leading cause of premature death in the UK with some of the highest hospitalisations in the country seen in areas of socioeconomic deprivation. Read more
MSc by Research: Non-canonical functions of SRSF protein kinase (SRPK) in pluripotent stem cells
The overarching goal of our research is to identify and characterise the protein kinase signalling pathways that control stem cell pluripotency and differentiation and determine how protein kinase signalling is disrupted to cause human developmental disorders. . Read more
Genetic and biochemical evaluation of a Gaucher disease patient utilising induced pluripotent stem cell (IPSC) technologies
We are looking for a talented and motivated recent graduate in Neuroscience, Biosciences or related discipline to engage in an exciting new project at Manchester Metropolitan University in collaboration with the Inherited Metabolic Diseases clinical team at the . Read more
An omics approach to understand and treat KMT2C-related neurodevelopmental disorder using induced pluripotent stem cells and CRISPR-Cas9
Background. We recently identified a novel human syndrome caused by mutations in a gene called KMT2C1. Patients with this condition predominantly have developmental delay and intellectual disability indicating the important function of this gene in brain’s normal development and function. Read more
Human retinal organoids as a tool for investigating molecular mechanisms of retinal ciliopathies.
We are seeking a talented and motivated PhD student to join a research team headed by Dr. Tomas Barta at Masaryk University, Faculty of Medicine (. Read more
Characterisation and treatment of patient iPSC-derived retinal organoids as an in vitro model of inherited retinal disease
Commercial partner: . Newcells Biotech Ltd. , Newcastle upon Tyne. Induced pluripotent stem cell (iPSC) derived 3D retinal organoids (ROs) mimic the architecture of the mammalian retina and can therefore be used as a physiologically relevant in vitro model. Read more
Combined in vitro and in silico molecular analysis of CHD8 gene-mediated risk for ASD
Aim. To understand the molecular mechanisms by which mutation of the CHD8 gene increases risk of Autism Spectrum Disorder (ASD). Background. Read more
Generating human diabetic blood vessel organoids as a powerful model to investigate and treat the diabetic vasculopathy
In this project induced pluripotent stem cells will be derived diabetic patient specific blood vessel organoids. Read more
BBSRC White Rose DTP Studentship - Investigating functional conservation of Specialized ribosomes in eukaryotes
Ribosomes are the ancient cellular machines that perform protein synthesis. Although long considered uniform in both composition and function, recent findings have shown ribosomes to be far more heterogeneous than originally thought. Read more
Deciphering the regulation of NKX2-5, a key transcription factor in heart development, to uncover the fundamental mechanisms of cardiac cell development from stem cells
Our understanding of cardiac cell development remains incomplete, specifically how the progenitor cells, which give rise to the heart, are programmed to acquire cardiac potential. Read more
Mechanisms of gene regulation shared between human development and neurodegeneration
Applications are invited for a research studentship leading to the award of a PhD degree, under the supervision of Dr. Marco Trizzino, to investigate mechanisms of gene regulation shared between human development and neurodegeneration. Read more
Understanding cellular and molecular mechanisms that confer resilience in Amyotrophic Lateral Sclerosis
Research Group:
Centre for Clinical Brain Sciences
Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal neurogenerative disease with neither cure nor appreciable disease modifying treatments. Read more
PhD Studentship in Psychological Medicine and Clinical Neurosciences
Project Title. Untangling neurodegeneration and ageing components of neuroinflammatory disorders. Summary. Numerous genome-wide association studies (GWAS) show a strong, but poorly understood neuroinflammatory component to most neurological diseases. Read more
Functional assembly of 3D neuromuscular junctions on a chip for neuromotor disease modelling. MRC GW4 BioMed DTP PhD studentship 2023/24 Entry, PhD in Physics
Summary. The neuromuscular junction (NMJ) is an essential synapse for muscle contraction and movement. Understanding the functional establishment of an NMJ is crucial to studying neuromotor processes and associated diseases such as ALS. Read more
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