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pluripotent PhD Projects, Programs & Scholarships

We have 21 pluripotent PhD Projects, Programs & Scholarships

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  Induced pluripotent stem-cell (iPSC) reprogramming in bone and blood cancers (Ref:SF20/APP/PAL)
  Dr D Pal
Applications accepted all year round

Funding Type

PhD Type

iPSC (somatic cells reprogrammed to an embryonic-stem-cell-like state) are not only a means of patient relevant disease modelling, but de-differentiation of terminal cells to their primitive precursors often reveal aberrations in tissue development.
  Generation of universal donor transplant tissue by genomic engineering of induced pluripotent stem cells
  Dr F Manson, Dr T Wang
Applications accepted all year round

Funding Type

PhD Type

Project Description. Blindness can be caused by mutations in genes expressed in the retinal pigment epithelium (RPE), the tissue adjacent to the rod and cone photoreceptor cells that is essential for their normal function.
  Developing pluripotent stem cell models of inherited retinal diseases
  Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Background. Inherited retinal dystrophies are a leading cause of blindness and visual loss in the UK working age population. However, despite the widespread diagnostic use of next-generation sequencing, a molecular genetic diagnosis is unavailable for many patients world-wide.
  Early lineage specification in mammalian embryos
  Dr B Plusa
Applications accepted all year round

Funding Type

PhD Type

Growing understanding of the pre-implantation mammalian development resulted in significant advances in assisted reproduction techniques and in regenerative medicine field.
  Characterisation of the neuronal receptor for soluble amyloid precursor protein: a route to new therapeutic targets for Alzheimer’s disease
  Prof N Hooper, Prof M J Humphries
Applications accepted all year round

Funding Type

PhD Type

Alzheimer’s disease (AD) is the commonest form of dementia for which currently there is no means of stopping or even slowing the disease.
  Development of iPSCs from patients with Urofacial Syndrome for disease modelling
  Prof S J Kimber, Prof A Woolf
Applications accepted all year round

Funding Type

PhD Type

Peripheral neuropathies (PNs) affect 2% of the general population. Somatic PNs cause locomotor and sensory deficits, while autonomic PNs cause cardiac dysrhythmias and gastrointestinal and urinary bladder dysfunction.
  Tackling neurovascular dysfunction in dementia: a cell biology and biomaterials approach
  Prof N Hooper, Dr M Domingos, Dr T Wang
Applications accepted all year round

Funding Type

PhD Type

Neurovascular dysfunction is a central process in the pathogenesis of Alzheimer’s disease and other dementias. In the brain, vascular and neuronal structures are tightly integrated forming the multicellular neurovascular unit comprising endothelial cells, pericytes, astrocytes, microglia and neurons.
  The generation of RBCs in vitro from stem cell sources and the molecular regulation of erythropoiesis in health and disease
  Dr J Frayne
Applications accepted all year round

Funding Type

PhD Type

Development of systems for the generation of red blood cells (RBCs) from stem cell sources (adult peripheral blood, cord blood and pluripotent stem cells)…
  Expanded potential stem cells for regenerative medicine, immunotherapy, and biotechnology
  Prof P Liu
Applications accepted all year round

Funding Type

PhD Type

Embryonic stem cells (ES cells) and induced pluripotent stem cells (iPS cells) are pluripotent and thus hold great promise in regenerative medicine, studying disease mechanisms and drug discovery.
  Molecular dissection of blood cell fate determination
  Assoc Prof C Porcher
Application Deadline: 24 July 2020

Funding Type

PhD Type

Over the past decade, numerous efforts have been deployed to reproduce the development of HSCs in vitro from pluripotent stem cells as it happens in the embryo, for mechanistic and therapeutic purposes.
  Molecular dissection of blood cell fate determination
  Assoc Prof C Porcher
Application Deadline: 24 July 2020

Funding Type

PhD Type

Over the past decade, numerous efforts have been deployed to reproduce the development of HSCs in vitro from pluripotent stem cells as it happens in the embryo, for mechanistic and therapeutic purposes.
  Therapeutic models for Spinal muscular atrophy
  Prof R Yáñez-Muñoz
Applications accepted all year round

Funding Type

PhD Type

Our laboratory works on Gene Therapy in the Central Nervous System and Gene Repair, using novel viral vectors, gene targeting and induced pluripotent stem cells (iPSCs) as core technologies.
  Epigenetic regulation in heart failure and cardiac sudden death
  Dr X Wang, Dr V Liu
Applications accepted all year round

Funding Type

PhD Type

A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem.
  Autophagy and neuroinflammation in Parkinson’s
  Dr J D Lane
Applications accepted all year round

Funding Type

PhD Type

Autophagy is an essential catabolic process that protects cells against diverse stresses. Autophagy prevents many human diseases including neurodegeneration, so a complete understanding of this process is needed.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
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