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polymerase PhD Projects, Programs & Scholarships

We have 22 polymerase PhD Projects, Programs & Scholarships

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  MRC DiMeN Doctoral Training Partnership: The making of a Super Bug. Understanding the mechanisms of high level antibiotic resistance in Methicillin Resistant Staphylococcus aureus (MRSA)
  Prof S J Foster, Prof N Zenkin
Application Deadline: 21 January 2019
Supervisor. Professor Simon Foster (University of Sheffield). Co-supervisor. Professor Nikolay Zenkin (University of Newcastle). Background Information.
  Investigating the modulation of cellular responses as a consequence of long term Poly ADP Ribose Polymerase (PARP) inhibition therapy
  Dr T Gaymes
Applications accepted all year round
Approximately 30 years ago, Poly ADP Ribose Polymerase (PARP) activity was shown to play a critical role in the processes of DNA repair in nucleated cells.
  Biochemical analysis of the interaction of pluripotency transcription factors with RNA polymerase enzymes
  Research Group: Institute of Stem Cell Research
  Prof I Chambers
Application Deadline: 13 December 2018
Pluripotent stem cells possess the dual defining properties of self-renewal and multi-lineage differentiation potential. In order to retain an effective differentiation capacity, self-renewal must occur at high efficiency.
  The role of the RNA Polymerase II CTD kinases in regulation of transcription, RNA processing and the cell cycle.
  Prof S Murphy
Application Deadline: 11 January 2019
The multiple Tyr1Ser2Pro3Thr4Ser5Pro6Ser7 repeats within the carboxyl-terminal domain (CTD) of the large subunit of RNA polymerase II (pol II) undergo reversible phosphorylation during transcription of human protein-coding genes1.
  Innate immune responses to influenza virus infection
  Prof E Fodor
Application Deadline: 11 January 2019
Influenza viruses are important human and animal pathogens; they cause widespread clinical and veterinary disease and have a considerable economic impact.
  Why do some DNA sequences poison cells?
  Research Group: BBSRC MIBTP
  Dr D Grainger
Applications accepted all year round
Life on our planet is permitted by an ancient set of instructions encoded by DNA. Consequently, the observation that a cell can be poisoned by its own DNA is completely counterintuitive.
  Targeting transcription termination/antitermination in Staphylococcus aureus by inhibition of NusB/E/G protein-protein interactions.
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Prof M Auer, Prof R Fitzgerald
Application Deadline: 13 December 2018
Due to antibiotic resistance, many bacterial infections have become almost impossible to treat, particularly multidrug resistant strains for example the ESKAPE pathogens.
  Structural mechanism of signal-dependent gene transcription
  Prof D Panne, Dr A Revyakin
Application Deadline: 6 January 2019
The control of gene transcription is one of the main regulatory steps for cellular gene regulation.
  Defining the ‘molecular signature’ of PARP inhibitor sensitivity in blood cancers
  Dr T Gaymes
Applications accepted all year round
Despite significant advances in the understanding of the biology of blood cancers, identification of the most effective and safe form of treatment continues to present a formidable challenge to clinicians.
  Characterize the role of Treacle (TCOF1) in AKT-regulated ribosome biogenesis
  Prof R. Pearson, Dr J Kang
Applications accepted all year round
Ribosomes are essential for cell growth and proliferation, and their biogenesis requires exquisite regulation.
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