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polymerase PhD Projects, Programs & Scholarships

We have 18 polymerase PhD Projects, Programs & Scholarships

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We have 18 polymerase PhD Projects, Programs & Scholarships

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Targeting polymerase theta as a way to improve radiotherapy and immunotherapy.

Despite technical improvements in radiation delivery, survival rates following radical radiotherapy remain poor for many tumour types and the radiation delivered to adjacent tissues is still frequently associated with significant side-effects. Read more

Post-translation regulation of DNA polymerase activity at the eukaryotic replication fork

  Research Group: Biomedical Sciences Research Centre
In all forms of life, successful high-fidelity chromosomal DNA replication requires the complex interplay of a variety of essential and non-essential protein factors in a spatially and temporally coordinated manner. Read more

The molecular mechanisms of RNA Polymerase II termination

Our research aims to understand how mRNAs are produced by RNA Polymerase II (Pol II). It defines every aspect of cell and organismal function, and its misregulation can lead to the broadest and most devastating range of diseases. Read more

EASTBIO Investigating the effects of plasmid-borne mutagenic DNA polymerases on the evolution of antibiotic resistance.

  Research Group: Institute of Cell Biology
Antibiotics from the b-lactam family have been a cornerstone of both human and animal medicine but with increasing bacterial resistance to many first and second-line drugs, clinicians are forced to use b-lactams of ‘last resort’, such as carbapenems. Read more

EASTBIO COVID-19 Drug Discovery: Discovering Antiviral Compounds that Inhibit SARS-CoV-2 using a Cell-Based Approach.

  Research Group: Biomedical Sciences Research Centre
BACKGROUND. The COVID-19 pandemic is a global health and economic challenge. Despite successful vaccine development and ongoing vaccine rollout, effective treatment options are still urgently required for patients that succumb to serious disease. Read more

EASTBIO Seeing double: how do dsRNA binding pseudoenzymes regulate vertebrate mRNAs?

  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
Pre-mRNAs and mRNAs are regulated post-transcriptionally by a variety of different mechanisms that include splicing and editing, which alter the information content of the RNAs. Read more

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