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polymerase PhD Projects, Programs & Scholarships

We have 19 polymerase PhD Projects, Programs & Scholarships

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  A structural basis for the cross-talk between histones and RNA Polymerase II
  Prof R Stefl, Dr K Kubicek, Prof S Vanacova
Application Deadline: 31 October 2019

Funding Type

PhD Type

Chromatin is a highly flexible architecture in which spatially and temporally coordinated changes between structurally condensed states (transcriptionally repressive), and structurally accessible states (transcriptionally active) regulate gene expression.
  Molecular mechanisms of influenza virus replication
  Prof E Fodor
Application Deadline: 10 January 2020

Funding Type

PhD Type

Influenza viruses are important human and animal pathogens; they cause widespread clinical and veterinary disease and have a considerable economic impact.
  Statistical physics of DNA replication
  Dr A Moura, Prof C Romano
Applications accepted all year round

Funding Type

PhD Type

The goal of this project is to apply statistical physics and probability theory to the problem of DNA replication in living cells.
  A multiple modality approach for targeting treatment-resistant ovarian cancer
  Dr E. Sanij, Prof R. Pearson
Applications accepted all year round

Funding Type

PhD Type

High-grade serous ovarian cancer (HGSOC) accounts for 70% of ovarian cancer (OvCa) deaths and its five-year survival rate is 43%.
  Engineering tRNA neochromosomes in yeast
  Prof P Cai, Prof D Delneri
Applications accepted all year round

Funding Type

PhD Type

Advances in DNA synthesis technology have led to rapid growth in the field of synthetic biology, heralding a nascent era of synthetic genomics.
  Why do some DNA sequences poison cells?
  Research Group: BBSRC MIBTP
  Dr D Grainger
Applications accepted all year round

Funding Type

PhD Type

Life on our planet is permitted by an ancient set of instructions encoded by DNA. Consequently, the observation that a cell can be poisoned by its own DNA is completely counterintuitive.
  Characterization of cyclin-dependent kinase 12 (CDK12) substrates and their roles in regulation of transcription and tumorigenesis
  Dr D Bla┼żek, Prof Z Zdrahal
Application Deadline: 31 October 2019

Funding Type

PhD Type

Cdk12 is transcriptional cyclin-dependent kinase (Cdk) found mutated in various cancers. In previous studies we found that Cdk12 maintains genome stability via optimal transcription of key homologous recombination repair pathway genes including BRCA1.
  Cracking the CTD code
  Prof R Stefl, Dr K Kubicek, Dr P Plevka
Application Deadline: 31 October 2019

Funding Type

PhD Type

The concept of the CTD code that specifies the position of RNAPII in the transcriptional cycle and thus recruits specific processing factors, was suggested almost a decade ago.
  Structure, function and evolution of plant telomere components
  Prof J Fajkus, Prof J Palecek
Application Deadline: 31 October 2019

Funding Type

PhD Type

Telomeres are terminal, but nevertheless integral parts of chromosomes, and as such they are also formed and function as supramolecular nucleoprotein (chromatin) structures.
  mRNA translation reprogramming and metabolic re-wiring in response to ribosome-targeted therapies
  Prof R. Pearson, Dr J Kang
Applications accepted all year round

Funding Type

PhD Type

Increased synthesis and activity of ribosomes are associated with oncogenesis downstream of the major oncogenes including MYC, RAS and PI3K.
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