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polymerase PhD Projects, Programs & Scholarships

We have 18 polymerase PhD Projects, Programs & Scholarships

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  Structure, dynamics and interactions of subunits of RNA polymerase of Gram-positive bacteria
  Prof L Zidek, Dr P Kaderavek
Application Deadline: 15 March 2019
Certain RNA polymerase subunits (including sigma factors) are specific for Gram-positive bacteria. Such subunits are critical determinants of the enzyme specificity for DNA promoter sequence.
  MRC DiMeN Doctoral Training Partnership: The making of a Super Bug. Understanding the mechanisms of high level antibiotic resistance in Methicillin Resistant Staphylococcus aureus (MRSA)
  Prof S J Foster, Prof N Zenkin
Application Deadline: 21 January 2019
Supervisor. Professor Simon Foster (University of Sheffield). Co-supervisor. Professor Nikolay Zenkin (University of Newcastle). Background Information.
  A structural basis for the cross-talk between histones and RNA Polymerase II
  Prof R Stefl, Dr K Kubicek, Prof S Vanacova
Application Deadline: 3 February 2019
Chromatin is a highly flexible architecture in which spatially and temporally coordinated changes between structurally condensed states (transcriptionally repressive), and structurally accessible states (transcriptionally active) regulate gene expression.
  Cancer Research UK funded 4 year studentship: RNA Pol II subunits in the regulation of transcription and genome instability
  Dr M Saponaro, Dr A Gambus
Application Deadline: 15 February 2019
Applications are invited for a non-clinical PhD studentship at the Cancer Research UK (CRUK) Birmingham Centre.
  Why do some DNA sequences poison cells?
  Research Group: BBSRC MIBTP
  Dr D Grainger
Applications accepted all year round
Life on our planet is permitted by an ancient set of instructions encoded by DNA. Consequently, the observation that a cell can be poisoned by its own DNA is completely counterintuitive.
  Defining the ‘molecular signature’ of PARP inhibitor sensitivity in blood cancers
  Dr T Gaymes
Applications accepted all year round
Despite significant advances in the understanding of the biology of blood cancers, identification of the most effective and safe form of treatment continues to present a formidable challenge to clinicians.
  Characterization of cyclin-dependent kinase 12 (CDK12) substrates and their roles in regulation of transcription and tumorigenesis
  Dr D Blažek, Prof Z Zdrahal
Application Deadline: 3 February 2019
Cdk12 is transcriptional cyclin-dependent kinase (Cdk) found mutated in various cancers. In previous studies we found that Cdk12 maintains genome stability via optimal transcription of key homologous recombination repair pathway genes including BRCA1.
  Cracking the CTD code
  Prof R Stefl, Dr K Kubicek, Dr P Plevka
Application Deadline: 3 February 2019
The concept of the CTD code that specifies the position of RNAPII in the transcriptional cycle and thus recruits specific processing factors, was suggested almost a decade ago.
  Characterize the role of Treacle (TCOF1) in AKT-regulated ribosome biogenesis
  Prof R. Pearson, Dr J Kang
Applications accepted all year round
Ribosomes are essential for cell growth and proliferation, and their biogenesis requires exquisite regulation.
  Are ticks a potential vector for Borna disease virus?
  Prof S Tasker
Applications accepted all year round
Background. Borna disease virus (BDV) has a broad host range including cats and dogs. In cats BDV causes a non-suppurative. meningoencephalomyelitis called “staggering disease”.
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