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protein PhD Projects, Programmes & Scholarships

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We have 440 protein PhD Projects, Programmes & Scholarships

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Structure and function of Batten disease proteins

The neuronal ceroid lipofucscinoses are a group of inherited neurodegenerative disorders with primarily childhood onset. The most common form, also known as Batten disease or CLN3 disease, is caused by recessively inherited mutation in the CLN3 gene. Read more

Lipid-based implants for sustained protein release

Protein-based therapeutics are an important class of medicine with significant value for the treatment of many relevant disorders such as cancers, inflammation, and exposure to infectious diseases. Read more

MSc by Research: Non-canonical functions of SRSF protein kinase (SRPK) in pluripotent stem cells

The overarching goal of our research is to identify and characterise the protein kinase signalling pathways that control stem cell pluripotency and differentiation and determine how protein kinase signalling is disrupted to cause human developmental disorders. . Read more

Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation

Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more

Modular design and construction of de novo protein nanowires and light harvesting arrays

Electron and captured energy flow within proteins is essential to life; these phenomena underpin cellular respiration and photosynthesis, both of which are dependent on complex protein machinery that support chains of redox active cofactors or chromophores. Read more

Engineering biology for next-generation electronics: Building integrated bionanohybrid circuits by design.

Merging ideas and principles from biology with nanoscience has proved pivotal in improving our fundamental understanding of nature and the generation of new technologies that improve our everyday lives. Read more

Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials

Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function. Read more

Therapeutic targeting of chemokines in inflammation

Protein interactions underlie most biological processes but are challenging to target using small molecule drugs. Many protein interactions are mediated by short-linear-interacting motifs (SLiMs) that range from 3-12 amino acid residues (1, 2). Read more

In silico glycosylation of AlphaFold protein structural models.

Background. The recent release of the AlphaFold Protein Structure Database by DeepMind and EMBL-EBI has made available to the scientific community highly accurate structural predictions for 20,000 human proteins and those from 20 other biologically relevant organisms. Read more

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