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protein PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

We have 383 protein PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships

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Bifunctional small molecules beyond PROTACs: Proximity-inducing new downstream chemistries to rewire cell signalling

Proteolysis targeting chimeras (PROTACs) are a popular class of bifunctional molecules that simultaneously engage a target protein on one end and an E3 ubiquitin ligase on the other end, forming a ternary complex that facilitates the rapid ubiquitylation and subsequent degradation of the target protein. Read more

Structure and function of Batten disease proteins

The neuronal ceroid lipofucscinoses are a group of inherited neurodegenerative disorders with primarily childhood onset. The most common form, also known as Batten disease or CLN3 disease, is caused by recessively inherited mutation in the CLN3 gene. Read more

Enhancing Protein Thermal Stability for Melt Processing

Protein therapeutics are an important class of medicines with renowned efficacy in the treatment of several relevant disorders. Despite significant advantages, protein delivery remains a significant challenge. Read more

The mechanism of regulation of protein synthesis via eIF2 molecular complexes

Control of protein synthesis is critical for normal metabolism, development and responses to stress. One major pathway is called the integrated stress response (ISR) and centres on translational control of the general protein synthesis factor eIF2B via the phosphorylation of eIF2 [1,2]. Read more

Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation

Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more

MSc by Research: Non-canonical functions of SRSF protein kinase (SRPK) in pluripotent stem cells

The overarching goal of our research is to identify and characterise the protein kinase signalling pathways that control stem cell pluripotency and differentiation and determine how protein kinase signalling is disrupted to cause human developmental disorders. . Read more

Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials

Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function. Read more

New protein modification chemistries for studying protein structure and function

Chemically modified proteins can be used to understand, treat, and diagnose disease. However, relatively few chemical reactions can be used to modify proteins, severely limiting the diversity and applications of new technologies. Read more
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Analysis of protein S-acylation with modern mass spectrometry techniques

We are seeking a PhD student to study protein post translational modifications (PTMs) with native mass spectrometry. Ideal applicants will have experience in cell biology/biochemistry and/or mass spectrometry/analytical chemistry. Read more

Engineering Protein Nanocompartments for Biotechnological Applications

Protein nanocompartments have board applications as catalytic nanoreactors and as carriers for therapeutics delivery. They are self-assembled protein-based supramolecules that have spherical and hollow architectures. Read more

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