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protein aggregation PhD Projects, Programs & Scholarships

We have 25 protein aggregation PhD Projects, Programs & Scholarships

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  Characterising surface properties of protein biopharmaceutical molecules
  Dr A Golovanov, Dr J Warwicker
Applications accepted all year round

Funding Type

PhD Type

Protein biologicals have great potential for the effective treatment of a wide range of diseases. However, aggregation and instability are inherent issues with all protein pharmaceuticals, which is a problem that can limit their utility and developability.
  Characterization the role RNA interaction in TDP-43 protein dynamic in neurons
  Dr HJ Chen, Dr M Plevin
Application Deadline: 5 January 2020

Funding Type

PhD Type

RNA-binding proteins (RBPs) play an important role in the neuronal system. Dysregulation of RBPs caused by cellular stress or disrupted protein.
  A novel class of excipients for stabilizing protein therapeutics
  Dr R Curtis, Dr J Warwicker
Applications accepted all year round

Funding Type

PhD Type

Biopharmaceutical proteins constitute a growing proportion of the drug catalogue for virtually all major pharmaceutical companies.
  Dynamics of protein folding on the ribosome
  Dr D Balchin
Application Deadline: 12 November 2019

Funding Type

PhD Type

This 4-year PhD studentship is offered in Dr David Balchin’s Group based at the Francis Crick Institute (the Crick). Proteins are synthesised on the ribosome as linear polypeptides that in most cases must fold into defined 3-D structures to be biologically active.
  Deep Learning / Bioinformatics Approach for Protein-Protein Interaction Prediction
  Dr JC Nebel
Applications accepted all year round

Funding Type

PhD Type

Since most molecular processes rely on protein–protein interactions PPIs), knowledge of those interactions is extremely valuable for biomedical research and drug design.
  Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials
  Dr V Liu, Dr L Swanton
Applications accepted all year round

Funding Type

PhD Type

Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function.
  Time-resolved analysis by cryo-electron microscopy of regulators of ubiquitin signalling
  Dr R Enchev
Application Deadline: 12 November 2019

Funding Type

PhD Type

This 4-year PhD studentship is offered in Dr Rado Enchev’s Group based at the Francis Crick Institute (the Crick).
  Real-time monitoring of biopharmaceutical aggregation under flow by fluorescence
  Dr R Curtis, Dr C Pereira da Fonte, Dr A Pluen
Applications accepted all year round

Funding Type

PhD Type

Biopharmaceutical proteins constitute a growing proportion of the drug catalogue for virtually all major pharmaceutical companies.
  SOD1 The Key protein for finding a cure for familial Motor Neurone Disease
  Dr S Antonyuk, Prof S Hasnain
Applications accepted all year round

Funding Type

PhD Type

Motor neurone disease is a progressive, fatal neurological disorder with no known cure. It is characterised by selective loss of motor neurons in the spinal cord and cortex.
  Cooperative, non-specific binding and aggregation in protein/RNAinteractions: Beyond stoichiometry, specificity, and discrete binding sites
  Dr M Plevin, Dr S Shimizu
Application Deadline: 5 January 2020

Funding Type

PhD Type

Interactions between biomolecules are typically considered to be both. specific and stoichiometric. Even in cases of multiple binding sites,.
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