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We have 30 protein aggregation PhD Projects, Programmes & Scholarships

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protein aggregation PhD Projects, Programmes & Scholarships

We have 30 protein aggregation PhD Projects, Programmes & Scholarships

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Chaperones and the response to protein misfolding stress

The University of Manchester Faculty of Biology, Medicine and Health
Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more
 Supervisors: Prof C M Grant, Prof M Ashe
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MRC DiMeN Doctoral Training Partnership: Optogenetic modelling of a hallmark neurodegeneration pathology for mechanistic research and drug discovery

University of Sheffield MRC DiMeN Doctoral Training Partnership
Background. The events during the initiation of pathological protein aggregation in neurodegenerative diseases of aging has to date been difficult to capture. Read more
 Supervisors: Dr T Shelkovnikova, Dr S Sweeney, Prof J Atack
 17 December 2023  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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BBSRC CASE Hybrid Mass Spectrometry and Microscopy to Visualize the Dynamics of Temperature Adaptive Proteins

The University of Manchester Department of Chemistry
This project will use ion mobility mass spectrometry and single molecule imaging to understand protein dynamics. It will focus on developing new methods to understand the conformational changes that occur to proteins as a protection mechanism to prevent protein aggregation due to low temperature. Read more
 Supervisors: Prof P Barran, Dr C Muryn, Dr R Appleby
 19 January 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Assessing the Impact of Aggregation-Prone Proteins on the Mitochondrial-Metallome Interplay in a Novel 3D Spheroid Cholinergic Cell Model of Neurodegenerative Disease

University of Birmingham School of Biomedical Sciences
Although showing diverse symptoms affecting cognition and movement, the brains of patients with neurodegenerative disorders (NDs) display similar neuropathological features namely protein aggregation within the brain. Read more
 Supervisors: Dr I Pienaar, Prof J.F. Collingwood
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Assessing the Impact of Aggregation-Prone Proteins on the Mitochondrial-Metallome Interplay in a Novel 3D Spheroid Cholinergic Cell Model of Neurodegenerative Disease

University of Birmingham Institute of Clinical Sciences
Although showing diverse symptoms affecting cognition and movement, the brains of patients with neurodegenerative disorders (NDs) display similar neuropathological features namely protein aggregation within the brain. Read more
 Supervisors: Dr I Pienaar, Prof J.F. Collingwood
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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White Rose BBSRC DTP i-CASE with UCB Cell Tech: Hitting the target: creating tractable target proteins without losing function for the Biopharmaceutical Sector

University of Leeds White Rose BBSRC Doctoral Training Partnership
The ability to produce and characterize potential protein target is an essential first step in the drug discovery pipeline. If this target is difficult to handle due to poor expression, low stability or tendency to aggregate it can slow or even preclude timely and cost-effective drug development. Read more
 Supervisors: Prof D B Brockwell, Prof S E Radford
 Open Day(s)  7 January 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Engineering Developable Biopharmaceuticals

University of Leeds Faculty of Biological Sciences
The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2023/24. Read more
 Supervisors: Prof D B Brockwell, Prof S E Radford
 Open Day(s)  Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Exploring Synthetic Lethality Interactions through Targeting the SUMO Pathway for Therapeutic Insights

University of Leeds Faculty of Biological Sciences
The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2023/24. Read more
 Supervisor: Dr C Bassi
 Open Day(s)  Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Protein misfolding and aggregation in biomolecular condensates

Ruhr-University Bochum Ruhr-University Bochum
Protein misfolding and aggregation in biomolecular condensates. We offer a 3 year PhD position that is jointly financed and supervised by Prof. Read more
 Supervisor: Prof S Ebbinghaus
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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China Scholarship Council: The molecular and cellular biology of dementia and motor neuron disease

University of Dundee School of Life Sciences
Protein aggregation is central to dementia and motor neuron disease. Understanding how proteins become aggregated in disease will help us to better understand potential causes and may lead to new treatments. Read more
 Supervisors: Dr L McGurk, Dr A Rousseau
 31 January 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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(BBSRC DTP) Delineating the gene expression timeline of a mitochondrial stress response regulating ageing

The University of Manchester Faculty of Biology, Medicine and Health
The genome is the blueprint of any living systems. However, it is the regulation of gene expression that enables life. For transcription to take place, the molecular machinery involved must access genomic DNA. Read more
 Supervisors: Dr G Poulin, Dr A J Whitmarsh, Prof C M Grant
 19 January 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Learning a universal biomolecular force field

Medical Research Council (Cambridge) Laboratory of Molecular Biology
Molecular dynamics has been successful in obtaining biological insights by simulating the motion of biomolecules. Increases in compute power mean that simulations will soon reach the time scales on which much of biology happens. Read more
 Supervisor: Dr J Greener
 5 December 2023  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials

The University of Manchester Faculty of Biology, Medicine and Health
Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function. Read more
 Supervisors: Dr V Liu, Dr L Swanton
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Post-mortem characterisation and organotypic culture modelling of DNA damage in Alzheimer’s disease and dementia with Lewy bodies

University of Dundee School of Medicine
Neurodegenerative dementias, such as Alzheimer’s disease and Dementia with Lewy bodies are growing medical and social issues. Whilst recent advancements in Alzheimer’s disease therapies have been hailed as clinical breakthroughs, the reality is that meaningful treatment for these diseases remain lacking. Read more
 Supervisor: Dr D Koss
 8 December 2023  PhD Research Project  Funded PhD Project (UK Students Only)
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Investigating the Roles for deSUMOylation Enzyme SENP3 in Autophagy Impaired by α-synuclein

University of Sheffield School of Biosciences
Aggregation of α-synuclein protein in neuronal cells has been strongly implicated in the pathogenesis of neurodegenerative disorders (Synucleinopathies) including Parkinson's disease and dementia with Lewy bodies. Read more
 Supervisor: Dr C Guo
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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