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protein aggregation PhD Projects, Programs & Scholarships

We have 16 protein aggregation PhD Projects, Programs & Scholarships

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  Characterising surface properties of protein biopharmaceutical molecules
  Dr A Golovanov, Dr J Warwicker
Applications accepted all year round
Protein biologicals have great potential for the effective treatment of a wide range of diseases. However, aggregation and instability are inherent issues with all protein pharmaceuticals, which is a problem that can limit their utility and developability.
  A novel class of excipients for stabilizing protein therapeutics
  Dr R Curtis, Dr J Warwicker
Applications accepted all year round
Biopharmaceutical proteins constitute a growing proportion of the drug catalogue for virtually all major pharmaceutical companies.
  Deciphering Roles of SUMOylation in mini-Human Brains in Health and Disease
  Dr C Guo, Dr S Brown
Applications accepted all year round
Neurodegenerative disorders and cerebral ischemia are incurable conditions, imposing tough medical challenges and a substantial economic burden on health services.
  Deep Learning / Bioinformatics Approach for Protein-Protein Interaction Prediction
  Dr JC Nebel
Applications accepted all year round
Since most molecular processes rely on protein–protein interactions PPIs), knowledge of those interactions is extremely valuable for biomedical research and drug design.
  Predicting the conversion of LRRK2 carriers to Parkinson disease: the role of blood and CSF biomarkers
  Dr E Sammler
Applications accepted all year round
Parkinson’s disease is a progressive neurodegenerative disease affecting up to 1:500 people over the age of 50 years.1 The risk of developing Parkinson’s…
  Real-time monitoring of biopharmaceutical aggregation under flow by fluorescence
  Dr R Curtis, Dr C Pereira da Fonte, Dr A Pluen
Applications accepted all year round
Biopharmaceutical proteins constitute a growing proportion of the drug catalogue for virtually all major pharmaceutical companies.
  Protein quality control and neurodegenerative disease - to test the hypothesis that BAG6 contributes to the quality control of a range of disease-linked proteins in the cytosol
  Dr L Swanton, Prof S High
Applications accepted all year round
Misfolded proteins represent a continuous threat to cell viability, which if allowed to accumulate can disrupt cellular function and induce cell death [1].
  The effect of differential glycosylation on human recombinant protein secretion, function and clearance
  Dr A Almond, Prof A J Dickson, Dr J Warwicker
Applications accepted all year round
This project aims to investigate the effect of glycosylation on the secretion, physical properties, and functional biological and physiological properties of human recombinant proteins.
  Cooperative, non-specific binding and aggregation in protein/RNA interactions: Beyond stoichiometry, specificity, and discrete binding sites
  Dr S Shimizu, Dr M Plevin
Applications accepted all year round
Interactions between biomolecules are typically considered to be both specific and stoichiometric. Even in cases of multiple binding sites, cooperative binding models have been successful in reproducing the sigmoidal binding curves seen in experiment (e.g., hemoglobin).
  Mitochondrial protein folding and diseases
  Prof L-Y Lian, Dr D Criddle
Applications accepted all year round
Many diseases, including cancer and neurological disease, stem from mitochondrial dysfunctions often triggered by sudden elevation of agents such as calcium and reactive oxygen species.
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