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We have 16 protein crystallography PhD Projects, Programmes & Scholarships
protein crystallography PhD Projects, Programmes & Scholarships
We have 16 protein crystallography PhD Projects, Programmes & Scholarships
Translating Deep Learning protein bioinformatics methods to accelerate structural determination by X-ray crystallography
Even after the AlphaFold 2 (AF2) revolution, experimental structural biology contributes enormously to advances across all areas of biology. Read more
Design of metallo coiled coil MRI contrast agents
This PhD project will develop a new class of MRI contrast agents. MRI is an essential tool for medical diagnosis. Contrast agents play a crucial role in improving the images obtained, and hence patient outcomes. Read more
Structural and functional analysis of the protein complexes which regulate cell fate decisions to identify novel cancer therapies
Whether a cell dies or not has profound consequences on health and disease. In healthy tissue, cells that acquire high levels of genetic damage are safely removed via a process of programmed cell death. Read more
The identification of allosteric inhibitors of high value therapeutic targets
This study will develop a novel approach to identify allosteric inhibitor sites on a wide variety of high-value therapeutic targets, including protein kinases, protein phosphatases and small G-proteins. Read more
Mining the Hippo signalling pathway for novel anti-cancer therapeutics
Candidates are invited to join the Kadri Lab, where our research focuses on developing innovative chemical approaches for discovering novel therapeutics to address unmet global health needs. Read more
Structural and functional characterisation of MALT1 ubiquitination to aid in the development of novel anti-cancer therapies
Nuclear factor-kappa B (NF-kB) is a family of transcription factors that play a crucial role in regulating various cellular processes; primarily related to immune responses, inflammation, and cell survival. Read more
Characterisation of how pro-peptide regions of collagen control extracellular matrix homeostasis, in health and musculoskeletal diseases
Collagen-I (‘collagen’ from hereon) is the most abundant protein in the human body (circa 25% of total protein mass), providing structure to organs with very different functions (e.g. Read more
Exploiting Deep Learning-based protein structure prediction for function annotation and structural biology
Applications will be reviewed until a suitable candidate is appointed. Protein structural information is crucial for an understanding of protein function and evolution. Read more
GW4 BioMed2 MRC DTP PhD project: Tackling Antimicrobial Resistance with Targeted Covalent Macrocycles
This project is one of a number that are in competition for funding from the GW4 BioMed2 MRC Doctoral Training Partnership which is offering up to 21 studentships for entry in September 2025. Read more
Understanding KANK1 contribution to neuronal health and disease.
Motor Neurone Disease (MND) is a catastrophic disease with a 100% fatality rate but is mechanistically poorly understood. Recently, αβ-integrin heterodimers have been implicated in neurodegeneration. Read more
Structural investigation of oncogenic splicing factors
More than 90% of human genes can and do express multiple proteins. This is achieved by a process called alternative RNA splicing, which is an essential step in gene expression in mammals. Read more
Obtaining an integrated understanding of oncogenic RAS signalling
The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. The physiological importance of RAS signalling is evident as about 25% of all human cancers harbour mutations in ras genes, where kras is most frequently mutated (about 18%) (COSMIC, v94). Read more
Structural biology tools to investigate and target ubiquitin system proteases in cancer
Ubiquitination targets proteins for degradation and regulates virtually all cellular signalling pathways in eukaryotes. The human genome encodes over 50 ubiquitin specific proteases (USPs) that cleave ubiquitin from modified proteins to salvage them from proteasomal degradation. Read more
Unravelling the mechanisms behind plant stress sensing
Agricultural production and food security are severely threatened by the loss of arable land and climate change, with increasingly harsher droughts, floods, and heat waves reducing crop productivity by more than 50%. Read more
How do atypical E3 ligases facilitate their biology?
The covalent attachment of the small protein ubiquitin to substrates regulates virtually all cellular processes and its modulation with small molecules is set to revolutionise modern medicine. Read more
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