protein expression PhD Projects, Programs & Scholarships

PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.

This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.

Inherited developmental disorders account for much of childhood visual impairment. Development of the eye requires cell fate decisions that balance stem cell proliferation and differentiation.

Going across temporal scales: how are oscillatory dynamics of protein expression decoded in the bursty expression of downstream genes in neurogenesis?

The University of Manchester
Faculty of Biology, Medicine and Health

Prof N Papalopulu, Prof H Ashe

Applications accepted all year round

Funding Type

PhD Type

PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.

This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.

In recent years, our understanding of gene expression dynamics has been transformed by the application of single cell molecular and imaging technologies.

Optimisation of gene expression routes for heterologous protein expression in CHO cells

University of Sheffield
Department of Molecular Biology and Biotechnology

Dr P Mitchell

Applications accepted all year round

Funding Type

PhD Type

PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.

This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.

CHO cells are commonly used as a vehicle for the production of heterologous proteins in the biopharmaceutical industry. We are currently using gene knock down and knock in approaches to increase the expression level of target recombinant proteins for potential use in industrial scale applications.

Development of Intronless Expression Plasmids for Biomanufacturing of Therapeutic Proteins

University of Sheffield
Department of Molecular Biology and Biotechnology

Prof S A Wilson, Dr E Thomson, Dr I Sudbery

Application Deadline: 10 January 2020

Funding Type

PhD Type

Funded PhD Project (European/UK Students Only)

PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.

This project has funding attached for UK and EU students, though the amount may depend on your nationality. Non-EU students may still be able to apply for the project provided they can find separate funding. You should check the project and department details for more information.

Therapeutic proteins such as antibodies are a successful class of biologic drug used to treat a wide range of diseases in areas such as oncology, respiratory, inflammation, autoimmunity and cardiology.

Dynamics of protein folding on the ribosome

The Francis Crick Institute
PhD Programme

Dr D Balchin

Application Deadline: 12 November 2019

Funding Type

PhD Type

Funded PhD Project (Students Worldwide)

PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.

This project has funding attached, subject to eligibility criteria. Applications for the project are welcome from all suitably qualified candidates, but its funding may be restricted to a limited set of nationalities. You should check the project and department details for more information.

This 4-year PhD studentship is offered in Dr David Balchin’s Group based at the Francis Crick Institute (the Crick). Proteins are synthesised on the ribosome as linear polypeptides that in most cases must fold into defined 3-D structures to be biologically active.

Characterisation of the genotype and phenotype of epithelial cells invaded by the periodontal pathogen Porphyromonas gingivalis.

University of Sheffield
School of Clinical Dentistry

Dr S Whawell, Dr G Stafford

Applications accepted all year round

Funding Type

PhD Type

PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.

This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.

The presence of the Gram negative anaerobe Porphyromonas gingivalis is consistently associated with the more severe forms of periodontal disease and its ability to invade host epithelial cells is thought to be important in the pathogenesis of the disease.

Chemical biology approaches to study the ubiquitin system

The Francis Crick Institute
PhD Programme

Dr K Rittinger

Application Deadline: 12 November 2019

Funding Type

PhD Type

Funded PhD Project (Students Worldwide)

PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.

This project has funding attached, subject to eligibility criteria. Applications for the project are welcome from all suitably qualified candidates, but its funding may be restricted to a limited set of nationalities. You should check the project and department details for more information.

This 4-year PhD studentship is offered in Dr Katrin Rittinger’s Group based at the Francis Crick Institute (the Crick).

Analysing the factors that regulate expression of blood-brain barrier drug transporter proteins

The University of Manchester
Faculty of Biology, Medicine and Health

Dr J L Penny, Dr C Demonacos

Applications accepted all year round

Funding Type

PhD Type

PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.

This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.

In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain.

Interplay between the translation of upstream open reading frames and ribosome nascent chain-associated factors to control gene expression in eukaryotic cells

The University of Manchester
Faculty of Biology, Medicine and Health

Dr M Pool, Prof G D Pavitt

Applications accepted all year round

Funding Type

PhD Type

PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.

This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.

Eukaryotic mRNAs typically contain one open reading frame that is translated into protein. However many mRNAs contain additional upstream ORFs (uORFs) that regulate protein expression by controlling the flow of ribosomes to the main ORF, often by regulated reinitiation.

Characterisation of the neuronal receptor for soluble amyloid precursor protein: a route to new therapeutic targets for Alzheimer’s disease

The University of Manchester
Faculty of Biology, Medicine and Health

Prof N Hooper, Prof M J Humphries

Applications accepted all year round

Funding Type

PhD Type

PhD Research Projects are advertised opportunities to examine a pre-defined topic or answer a stated research question. Some projects may also provide scope for you to propose your own ideas and approaches.

This project does not have funding attached. You will need to have your own means of paying fees and living costs and / or seek separate funding from student finance, charities or trusts.

Alzheimer’s disease (AD) is the commonest form of dementia for which currently there is no means of stopping or even slowing the disease.