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protein expression PhD Projects, Programs & Scholarships

We have 174 protein expression PhD Projects, Programs & Scholarships

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  Dynamic cell fate decisions: linking mechanical signals and protein expression dynamics in the developing eye to understand human developmental disorders
  Dr Cerys Manning, Prof N Papalopulu
Applications accepted all year round

Funding Type

PhD Type

Inherited developmental disorders account for much of childhood visual impairment. Development of the eye requires cell fate decisions that balance stem cell proliferation and differentiation.
  Going across temporal scales: how are oscillatory dynamics of protein expression decoded in the bursty expression of downstream genes in neurogenesis?
  Prof N Papalopulu, Prof H Ashe
Applications accepted all year round

Funding Type

PhD Type

In recent years, our understanding of gene expression dynamics has been transformed by the application of single cell molecular and imaging technologies.
  Optimisation of gene expression routes for heterologous protein expression in CHO cells
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

CHO cells are commonly used as a vehicle for the production of heterologous proteins in the biopharmaceutical industry. We are currently using gene knock down and knock in approaches to increase the expression level of target recombinant proteins for potential use in industrial scale applications.
  Validation of novel biomarkers for improved risk stratification and therapy for the paediatric cancer neuroblastoma
  Dr V See, Dr A Herrmann
Applications accepted all year round

Funding Type

PhD Type

Neuroblastoma is the second most common cancer in childhood but still has one of the lowest survival rates of all childhood malignancies.
  Nucleoside decoys, unravelling a novel plant pathogen virulence strategy
  Prof M Grant, Dr V Ntoukakis, Assoc Prof L Song
Application Deadline: 7 June 2020

Funding Type

PhD Type

Ensuring food security is critically important to our next generation and this encompasses a increase in productivity of 50% by 2050! We currently we lose 25-40% of global crop production to plant pathogens, thus significant progress could be made through improved plant disease resistance.
  Investigating the communication between cancer cells and cells in the tumour microenvironment to improve our understanding of epigenetic regulatory mechanisms and identify new targets for cancer therapy
  Prof K Gaston, Dr P-S Jayaraman
Applications accepted all year round

Funding Type

PhD Type

It is well-established that the molecular mechanisms controlling gene expression are disrupted in cancer cells and work in this area has laid the foundations for targeted cancer therapies.
  Involvement of the matrix protein SPARC in the dynamic interaction between tumour and host cells
  Dr G Stenbeck, Dr E Karteris
Applications accepted all year round

Funding Type

PhD Type

Tumour growth depends on the crosstalk between malignant and surrounding stromal cells (fibroblasts, osteoblasts, endothelial cells and inflammatory cells).
  Analysing the factors that regulate expression of blood-brain barrier drug transporter proteins
  Dr J L Penny, Dr C Demonacos
Applications accepted all year round

Funding Type

PhD Type

In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain.
  Interplay between the translation of upstream open reading frames and ribosome nascent chain-associated factors to control gene expression in eukaryotic cells
  Dr M Pool, Prof G D Pavitt
Applications accepted all year round

Funding Type

PhD Type

Eukaryotic mRNAs typically contain one open reading frame that is translated into protein. However many mRNAs contain additional upstream ORFs (uORFs) that regulate protein expression by controlling the flow of ribosomes to the main ORF, often by regulated reinitiation.
  Characterisation of the neuronal receptor for soluble amyloid precursor protein: a route to new therapeutic targets for Alzheimer’s disease
  Prof N Hooper, Prof M J Humphries
Applications accepted all year round

Funding Type

PhD Type

Alzheimer’s disease (AD) is the commonest form of dementia for which currently there is no means of stopping or even slowing the disease.
  Cutting off the fuel supply to calcium pumps in pancreatic cancer: a novel therapeutic strategy
  Dr J Bruce, Prof K Williams, Dr A P Gilmore
Applications accepted all year round

Funding Type

PhD Type

Background and Rationale. Pancreatic ductal adenocarcinoma (PDAC) has the poorest survival and limited treatment options. Therefore, the search for novel therapeutic targets and drugs designed to selectively kill PDAC cells must remain a central research strategy.
  Development of novel halogenase enzymes for biopharmaceutical applications
  Dr B Menon, Dr C Corre
Application Deadline: 7 June 2020

Funding Type

PhD Type

Identification of new halogenated synthetic, natural and non-natural compounds; and further exploitation and synthesis of these compounds are of extreme importance in this modern era.
  Engineering microbial chemical factories to produce renewable and modified biomaterials
  Dr B Menon, Dr C Corre
Application Deadline: 7 June 2020

Funding Type

PhD Type

The polymers, such as plastics are ubiquitous and integral in everyday human life with many applications that varies from medical, transport, electrical, construction and packaging.
  A bioinformatics approach to understanding protein solubility tags
  Dr J Warwicker, Dr R Curtis
Applications accepted all year round

Funding Type

PhD Type

The crowded environment of a cell cytoplasm reveals that proteins and other biological molecules co-exist at high macromolecular concentrations.
  Single-molecule analysis of structure and function of human transcription complexes using DNA origami nano-robots
  Research Group: Structural Biology and Molecular Enzymology
  Dr A Revyakin, Prof D Panne
Application Deadline: 6 June 2020

Funding Type

PhD Type

DNA origami is a rapidly evolving area of nanotechnology in which self-assembly properties of the DNA double helix are harnessed to build three-dimensional structures on the dimensional scale of ~50 nm.
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