Next-generation computational optimization of protein expression systems
Institute of Quantitative Biology, Biochemistry and Biotechnology
Dr D Oyarzun
13 December 2018
We are looking for a motivated doctoral student to work on an exciting project at the interface. of whole-cell modeling, optimization and industrial biotechnology.
Optimisation of gene expression routes for heterologous protein expression in CHO cells
Dr P Mitchell
Applications accepted all year round
CHO cells are commonly used as a vehicle for the production of heterologous proteins in the biopharmaceutical industry. We are currently using gene knock down and knock in approaches to increase the expression level of target recombinant proteins for potential use in industrial scale applications.
New ways to look at enzyme structures
Dr P C E Moody, Dr J Basran
6 January 2019
Metal-catalysed activation of oxygen in biology is achieved using either copper or iron. In the case of iron, this includes the heme-containing enzymes which activate oxygen.