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protein expression PhD Projects, Programmes & Scholarships
We have 138 protein expression PhD Projects, Programmes & Scholarships
We have 138 protein expression PhD Projects, Programmes & Scholarships
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Dynamic cell fate decisions: linking mechanical signals and protein expression dynamics in the developing eye to understand human developmental disorders
Inherited developmental disorders account for much of childhood visual impairment. Development of the eye requires cell fate decisions that balance stem cell proliferation and differentiation. Read more
Going across temporal scales: how are oscillatory dynamics of protein expression decoded in the expression of downstream genes in neurogenesis?
In recent years, our understanding of gene expression dynamics has been transformed by single-cell, molecular and imaging technologies. It was thought that genes are simply “on” or “off”, but we now appreciate that the dynamics are more complex. Read more
4-year PhD Studentship: Role of SAFB proteins in the regulation of miRNA function and aetiology of Huntington's disease
RNA binding proteins (RBP) play a central role in cellular metabolism by orchestrating the complex interactions of coding, non-coding, structural and regulatory RNA species. Read more
Understanding apoptotic heterogeneity in cell populations
Apoptosis is a form of programmed cell death that occurs in response to stress such as genomic damage. The decision to initiate apoptosis is taken at the outer mitochondrial membrane (OMM) by members of the Bcl-2 family of proteins. Read more
Oxidative protein folding of industrially and pharmaceutically important recombinant proteins
Oxidative protein folding (protein folding and disulphide bond formation) is important for function and stability of many proteins. Read more
Cold-Chain Stable Protein/Polymer Therapeutic Conjugates
By value, the largest segment of the pharmaceutical market is protein biologics, which includes antibody as well as gene therapies and vaccines. Read more
Analysing the factors that regulate expression of blood-brain barrier drug transporter proteins
In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain. Read more
4-year PhD Studentship: Can glomerular podocyte damage cause widespread vascular permeability in cardiovascular disease?
Cardiovascular disease is the leading cause of premature death in chronic kidney disease [1] and proteinuria is an independent risk factor of cardiovascular mortality [2]. Read more
Protein Biochemistry
Insect odorant receptors are a unique class of protein complexes evolved for odour sensing, with strong potential for electronic nose technology. Read more
Self funded BMS Project - Novel chemical tools for modifying protein structure
Chemically modified proteins can be used to understand, treat, and diagnose disease. However, relatively few chemical reactions can be used to modify proteins, severely limiting the diversity and applications of new technologies. Read more
Self-funded BMSProject: Metal-mediated chemical protein modification
Chemically modified proteins can be used to understand, treat, and diagnose disease. However, relatively few chemical reactions can be used to modify proteins, severely limiting the diversity and applications of new technologies. Read more
Characterisation of the neuronal receptor for soluble amyloid precursor protein: a route to new therapeutic targets for Alzheimers disease
Alzheimer’s disease (AD) is the commonest form of dementia for which currently there is no means of stopping or even slowing the disease. Read more
Identification of novel cortical interneuron regulators implicated in neuropsychiatric disorders
Despite representing only ~20% of the entire neuronal population in the neocortex, the GABAergic (Gamma-Aminobutyric Acid) inhibitory interneurons play a pivotal role in most cortical functions. Read more
Targeting protein acetylation to reduce microglia activation in neurodegenerative disorders
Recently, inhibitors of histone deacetylase enzymes (HDACs) have been identified as having potential therapeutic value for a range of neuronal disorders including Alzheimer’s disease, dementia and stroke [1, 2]. Read more
Protein structure and dynamics of the type six secretion system
Graduate student positions in Biochemistry and Microbiology. The Prehna Lab is looking for enthusiastic MSc or PhD students to join the Department of Microbiology at the University of Manitoba, Canada (. Read more