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We have 281 protein expression PhD Projects, Programmes & Scholarships

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protein expression PhD Projects, Programmes & Scholarships

We have 281 protein expression PhD Projects, Programmes & Scholarships

Understanding apoptotic heterogeneity in cell populations

Apoptosis is a form of programmed cell death that occurs in response to stress such as genomic damage. The decision to initiate apoptosis is taken at the outer mitochondrial membrane (OMM) by members of the Bcl-2 family of proteins. Read more

Introducing Artificial Metalloenzymes to Whole-Cell Biocatalysis

Background. Whole-cell biocatalysis is an attractive and cost-saving alternative to the use of purified enzymes. Given that the range of natural enzymes is limited, the potential of artificial metalloenzymes (ArMs) to create biocatalytic novelty is huge. Read more

Deciphering the Molecular Mechanisms of Mammalian RNA Virus Replication

Bunyaviruses are an order of viruses containing over 550 unique members that infect humans, animals, and plants. Some bunyaviruses have been labelled by the World Health Organisation as posing a great risk to public health due to the lack of effective countermeasures and capacity to spread extensively. Read more

Functional and structural characterisation of glycosyltransferases involved in protein mannosylation

Glycosylation is one the most abundant post-translational modifications and an evolutionary indicator. indeed the increasing complexity of host-pathogen and organism-environment interactions, amongst others, is reflected in the newly-reported ability of prokaryotes (e.g. Read more

Development and Application of Chemical Probes to target Protein-Protein Interactions

Project Outline. Transient protein-protein interactions (PPIs) control all cellular processes relevant to health and disease. Thus, a major problem in life-sciences research is to understand and manipulate PPIs with molecular and temporal resolution. Read more

New protein modification chemistries for studying protein structure and function

Chemically modified proteins can be used to understand, treat, and diagnose disease. However, relatively few chemical reactions can be used to modify proteins, severely limiting the diversity and applications of new technologies. Read more

Development of meal insects for the production of high value biologicals

There is growing demand for biologically active compounds, especially proteins. These can be used as valuable enzymes in production processes, may take the form of antibodies for the diagnosis and treatment of diseases, may function as antigens to elicit immune responses following vaccination, and may be engineered fibres with custom-build structural properties. Read more

Targeting Ras palmitoylation for the treatment of cancer

Lay summary. Proteins can be thought of as molecular machines that carry out work within cells. Protein activity can be regulated through the reversible attachment of certain chemical groups to specific amino acids within proteins. Read more

Structural-guided PROTAC targeting of BMX to modulate apoptotic sensitivity in disease

What determines at the molecular level whether a cell lives or dies? Regulation of the cellular life–death switch is essential in healthy cells for normal foetal development and for the clearance of damaged cells. Read more

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