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protein expression PhD Projects, Programs & Scholarships

We have 223 protein expression PhD Projects, Programs & Scholarships

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  Next-generation computational optimization of protein expression systems
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr D Oyarzun
Application Deadline: 13 December 2018
We are looking for a motivated doctoral student to work on an exciting project at the interface. of whole-cell modeling, optimization and industrial biotechnology.
  Optimisation of gene expression routes for heterologous protein expression in CHO cells
  Dr P Mitchell
Applications accepted all year round
CHO cells are commonly used as a vehicle for the production of heterologous proteins in the biopharmaceutical industry. We are currently using gene knock down and knock in approaches to increase the expression level of target recombinant proteins for potential use in industrial scale applications.
  (BBSRC DTP CASE) A synthetic biology approach to develop bacterial protein expression tools
  Prof J Micklefield, Dr A Green
Application Deadline: 31 January 2019
Streptomyces and related bacteria possess diverse biosynthetic pathways that produce a wide array of bioactive natural compounds including antibiotics, anti-cancer agents and other therapeutically important molecules.
  Insights into Transcription/Translation in Prostate Cancer through analyses of novel data sets
  Prof A Lynch
Applications accepted all year round
Approximately one in eight men will be diagnosed with prostate cancer (PCa) in his life, while a substantially higher proportion of men would show evidence of PCa under histopathological examination.
  New ways to look at enzyme structures
  Dr P C E Moody, Dr J Basran
Application Deadline: 6 January 2019
Metal-catalysed activation of oxygen in biology is achieved using either copper or iron. In the case of iron, this includes the heme-containing enzymes which activate oxygen.
  Developing mass spectrometry-based methods for protein-protein interaction analysis across the human cell division cycle
  Research Group: Institute of Cell Biology
  Dr T Ly, Dr D Clarke
Application Deadline: 13 December 2018
The temporal regulation of protein-protein interactions is a key feature of the cell division cycle. For example, progression from a quiescent (G0) to a proliferation-committed (G1) state is controlled by the interactions of a key protein called retinoblastoma (Rb).
  Airway, Liver and Muscle Gene Transfer to Create Therapeutic Protein Factories: utilising experience of in vivo gene transfer and/or in vivo gene editing to understand and manipulate the factors required for effective expression and secretion of therapeutic proteins
  Dr S Hyde, Dr D Gill
Application Deadline: 11 January 2019
We are focusing on strategies to deliver therapeutics via in vivo delivery of gene transfer vectors to generate ectopic “protein factories” capable of secreting therapeutic proteins into both the lung lumen and the systemic circulation.
  Using state-of-the-art proteomics to study the cellular and extracellular protein composition in human kidney disease; identification of novel biomarkers and bioactive drug targets in IgA Nephropathy
  Dr A Didangelos, Prof J Barratt
Applications accepted all year round
One of the key pathological characteristics of IgA nephropathy (IgAN) is the maladaptive and chronic accumulation and remodelling of the extracellular matrix (ECM) in affected glomeruli leading to fibrosis and progressive loss of function.
  (BBSRC DTP) Probing Regulatory Networks setting Notch signalling levels in vivo in Drosophila and Zebrafish.
  Dr M Baron, Dr S Herbert, Prof S Hubbard
Application Deadline: 31 January 2019
Development of organisms and maintenance of healthy tissues depends on proper control of cell to cell communication networks that control cell fate and behaviour.
  Analysing the factors that regulate expression of blood-brain barrier drug transporter proteins
  Dr J L Penny, Dr C Demonacos
Applications accepted all year round
In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain.
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