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We have 136 protein expression PhD Projects, Programmes & Scholarships
protein expression PhD Projects, Programmes & Scholarships
We have 136 protein expression PhD Projects, Programmes & Scholarships
PI3K-Akt expression in dysplastic oral lesions and implications for recurrence and malignant transformation
There are around 12,400 new head and neck cancer cases in the UK every year, that's 34 every day (2016-2018) with 4,143 deaths each year. Read more
The cellular response to stress: roles in disease and ageing
All living organisms need to adapt to their environment in order to survive and reproduce. They must respond to many stresses including altered oxygen levels, heat or cold, irradiation, infection and injury. Read more
Funded PhD- Investigating the mechanisms underlying Professional killer cell dysfunction in dengue
Background & preliminary data. Dengue virus (DENV) co-circulates as four serotypes (DENV1-4) and causes symptoms ranging from uncomplicated febrile illness to lifethreatening severe dengue (SD) characterized by plasma leakage, haemorrhage and hypovolemic shock. Read more
Targeting protein acetylation to reduce microglia activation in neurodegenerative disorders
The School of Biomedical Sciences invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more
Characterisation of how pro-peptide regions of collagen control extracellular matrix homeostasis, in health and musculoskeletal diseases
Collagen-I (‘collagen’ from hereon) is the most abundant protein in the human body (circa 25% of total protein mass), providing structure to organs with very different functions (e.g. Read more
Investigating the regulation of neutrophil gene expression by intracellular signalling and small non-coding RNAs
Immune-mediated inflammatory diseases (IMID) such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) affect millions of people worldwide and cause debilitating and disabling musculoskeletal disease. Read more
Assessing the Impact of Aggregation-Prone Proteins on the Mitochondrial-Metallome Interplay in a Novel 3D Spheroid Cholinergic Cell Model of Neurodegenerative Disease
Although showing diverse symptoms affecting cognition and movement, the brains of patients with neurodegenerative disorders (NDs) display similar neuropathological features namely protein aggregation within the brain. Read more
Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer
Research Group:
Institute of Cancer Therapeutics
Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working. Read more
PhD Studentship in Structural Biology of Membrane Proteins
A PhD studentship in membrane protein structural biology is available at the School of Biological Sciences, the University of Hong Kong. Read more
Creating patient-specific retinal organoids from human induced pluripotent stem cells for in vitro simulation of uveitis
Uveitis, although uncommon, is a notable cause of visual impairment and blindness. Uveitis encompasses a range of conditions driven by both innate autoinflammatory and adaptive autoimmune CD4 T-cell responses. Read more
Chemical modification of proteins via metal-mediated processes
Chemically modified proteins can be used to understand, treat, and diagnose disease. However, relatively few chemical reactions can be used to modify proteins, severely limiting the diversity and applications of new technologies. Read more
Structural investigation of oncogenic splicing factors
More than 90% of human genes can and do express multiple proteins. This is achieved by a process called alternative RNA splicing, which is an essential step in gene expression in mammals. Read more
Investigating the role of P2X7 receptor intracellular domains in cell signalling
Project description. P2X7 receptors are ion channels that are found on the surface of immune cells, where they respond to the binding of extracellular ATP, a damage signal released by dying cells in infection and injury. Read more
Assessing the molecular mechanisms by which Cathepsin V promotes breast cancer growth and metastasis
Targeted therapies such as tamoxifen, fulvestrant and anastrozole have exhibited significant clinical success since being introduced as treatments for Estrogen Receptor positive (ER+) breast cancer patients. Read more
Cryo-EM study of the human kinetochore
Our research is focused on understanding the mechanisms and regulation of chromosome segregation in mitosis. During the cell cycle, accurate chromosome segregation ensures that both daughter cells inherit the correct complement of chromosomes. Read more