Inherited developmental disorders account for much of childhood visual impairment. Development of the eye requires cell fate decisions that balance stem cell proliferation and differentiation. Read more
In recent years, our understanding of gene expression dynamics has been transformed by single-cell, molecular and imaging technologies. It was thought that genes are simply “on” or “off”, but we now appreciate that the dynamics are more complex. Read more
RNA binding proteins (RBP) play a central role in cellular metabolism by orchestrating the complex interactions of coding, non-coding, structural and regulatory RNA species. Read more
Apoptosis is a form of programmed cell death that occurs in response to stress such as genomic damage. The decision to initiate apoptosis is taken at the outer mitochondrial membrane (OMM) by members of the Bcl-2 family of proteins. Read more
By value, the largest segment of the pharmaceutical market is protein biologics, which includes antibody as well as gene therapies and vaccines. Read more
In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain. Read more
Cardiovascular disease is the leading cause of premature death in chronic kidney disease [1] and proteinuria is an independent risk factor of cardiovascular mortality [2]. Read more
Insect odorant receptors are a unique class of protein complexes evolved for odour sensing, with strong potential for electronic nose technology. Read more
Chemically modified proteins can be used to understand, treat, and diagnose disease. However, relatively few chemical reactions can be used to modify proteins, severely limiting the diversity and applications of new technologies. Read more
Chemically modified proteins can be used to understand, treat, and diagnose disease. However, relatively few chemical reactions can be used to modify proteins, severely limiting the diversity and applications of new technologies. Read more
Despite representing only ~20% of the entire neuronal population in the neocortex, the GABAergic (Gamma-Aminobutyric Acid) inhibitory interneurons play a pivotal role in most cortical functions. Read more
Recently, inhibitors of histone deacetylase enzymes (HDACs) have been identified as having potential therapeutic value for a range of neuronal disorders including Alzheimer’s disease, dementia and stroke [1, 2]. Read more
Graduate student positions in Biochemistry and Microbiology. The Prehna Lab is looking for enthusiastic MSc or PhD students to join the Department of Microbiology at the University of Manitoba, Canada (. Read more
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