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protein expression PhD Projects, Programs & Scholarships

We have 149 protein expression PhD Projects, Programs & Scholarships

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  Dynamic cell fate decisions: linking mechanical signals and protein expression dynamics in the developing eye to understand human developmental disorders
  Dr Cerys Manning, Prof N Papalopulu
Applications accepted all year round

Funding Type

PhD Type

Inherited developmental disorders account for much of childhood visual impairment. Development of the eye requires cell fate decisions that balance stem cell proliferation and differentiation.
  Going across temporal scales: how are oscillatory dynamics of protein expression decoded in the bursty expression of downstream genes in neurogenesis?
  Prof N Papalopulu, Prof H Ashe
Applications accepted all year round

Funding Type

PhD Type

In recent years, our understanding of gene expression dynamics has been transformed by the application of single cell molecular and imaging technologies.
  Optimisation of gene expression routes for heterologous protein expression in CHO cells
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

CHO cells are commonly used as a vehicle for the production of heterologous proteins in the biopharmaceutical industry. We are currently using gene knock down and knock in approaches to increase the expression level of target recombinant proteins for potential use in industrial scale applications.
  Development of Intronless Expression Plasmids for Biomanufacturing of Therapeutic Proteins
  Prof S A Wilson, Dr E Thomson, Dr I Sudbery
Application Deadline: 10 January 2020

Funding Type

PhD Type

Therapeutic proteins such as antibodies are a successful class of biologic drug used to treat a wide range of diseases in areas such as oncology, respiratory, inflammation, autoimmunity and cardiology.
  Dynamics of protein folding on the ribosome
  Dr D Balchin
Application Deadline: 12 November 2019

Funding Type

PhD Type

This 4-year PhD studentship is offered in Dr David Balchin’s Group based at the Francis Crick Institute (the Crick). Proteins are synthesised on the ribosome as linear polypeptides that in most cases must fold into defined 3-D structures to be biologically active.
  Characterisation of the genotype and phenotype of epithelial cells invaded by the periodontal pathogen Porphyromonas gingivalis.
  Dr S Whawell, Dr G Stafford
Applications accepted all year round

Funding Type

PhD Type

The presence of the Gram negative anaerobe Porphyromonas gingivalis is consistently associated with the more severe forms of periodontal disease and its ability to invade host epithelial cells is thought to be important in the pathogenesis of the disease.
  Chemical biology approaches to study the ubiquitin system
  Dr K Rittinger
Application Deadline: 12 November 2019

Funding Type

PhD Type

This 4-year PhD studentship is offered in Dr Katrin Rittinger’s Group based at the Francis Crick Institute (the Crick).
  Analysing the factors that regulate expression of blood-brain barrier drug transporter proteins
  Dr J L Penny, Dr C Demonacos
Applications accepted all year round

Funding Type

PhD Type

In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain.
  Interplay between the translation of upstream open reading frames and ribosome nascent chain-associated factors to control gene expression in eukaryotic cells
  Dr M Pool, Prof G D Pavitt
Applications accepted all year round

Funding Type

PhD Type

Eukaryotic mRNAs typically contain one open reading frame that is translated into protein. However many mRNAs contain additional upstream ORFs (uORFs) that regulate protein expression by controlling the flow of ribosomes to the main ORF, often by regulated reinitiation.
  Characterisation of the neuronal receptor for soluble amyloid precursor protein: a route to new therapeutic targets for Alzheimer’s disease
  Prof N Hooper, Prof M J Humphries
Applications accepted all year round

Funding Type

PhD Type

Alzheimer’s disease (AD) is the commonest form of dementia for which currently there is no means of stopping or even slowing the disease.
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