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We have 44 protein synthesis PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
protein synthesis PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 44 protein synthesis PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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The mechanism of regulation of protein synthesis via eIF2 molecular complexes
Control of protein synthesis is critical for normal metabolism, development and responses to stress. One major pathway is called the integrated stress response (ISR) and centres on translational control of the general protein synthesis factor eIF2B via the phosphorylation of eIF2 [1,2]. Read more
Regulatory roles for ribosome-associated proteins in protein synthesis
Protein synthesis is a highly-conserved, dynamic and tightly controlled process that is central to the activity of all cells. All phases of translation can be controlled. Read more
Investigating monogenic disorders of the protein synthesis machinery
Translation of mRNA into proteins is a critical cellular biological process. We recently described a novel human disorder, now called Faundes-Banka Syndrome (FABAS), caused by heterozygous variants in EIF5A1 that encodes a translation factor. Read more
Protein adsorption in gel structures: simulation, experiment and application
The aims of the project are to understand protein adsorption in RF gel structures and to tailor gel properties for applications; these include purification steps in protein manufacture, as well as water clean-up. Read more
Self-assembling Robots for Living Metamaterials and Novel Fabrication Methods
Background: . LEGO-like millimetre-sized electronic parts that self-assemble and become a robot - such a scenario has been a dream for engineers. Read more
Polymer-engineering nanocages for protein delivery
Protein therapeutics are a fast-acting and potent class of medicine with remarkable success in the treatment of several relevant disorders. Read more
Partitioning primary and secondary changes of gene expression caused by gene mutations
Control of gene expression is a complex cell process, which involves balancing both the synthesis and the degradation of RNA and protein so as to establish optimal levels of each protein. Read more
A mechanistic understanding of circadian clock-dependent regulation of the secretory pathway
The protein secretory pathway comprises a series of membranous compartments and transport vesicles that cells use to synthesise, post-translationally modify, and move proteins for delivery to the plasma membrane or for secretion to the extracellular matrix. Read more
MSc by Research: Is control of gene expression at the translational level important for limb development?
Ribosomes are core components of all cells required for the translation of mRNA into protein. Read more
Identification of the role of small nucleolar RNAs in cartilage ageing
University of Liverpool
Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
To reduce health inequities and improve the lives of older people we need to understand the ageing process at the molecular level. Read more
Specialised ribosomes in cancer: structural, biochemical and functional characterisation
he concept of specialised ribosomes with distinct protein and RNA composition and functional diversity has been recently proposed. Rapid proliferating… Read more
Understanding the structural consequences of ribosome specialisation
Protein synthesis by ribosomes (translation) and its regulation is essential to life. While it has been traditionally thought that ribosomes were not involved in the regulation of translation, it is now becoming clear that they do contribute. Read more
MSc by Research: Discovery and evaluation of targeted protein degrader probes for central nervous system disease research
In the UK alone, neurodegenerative diseases will affect 2 million people by 2051, have very limited effective treatments and cost the economy £26.3Bn annually. Read more
New macro-ligands for protein binding, and drug delivery.
Proteins bind and recognise each other using large surface areas. This recognition process is vital for a variety of biological applications. Read more
Studying protein homeostasis in healthy and malignant stem cell development
The Grey lab studies the role of protein homeostasis in healthy and malignant haematopoietic (blood) stem cell development. We focus on the proteome of healthy stem cells as they mature in vivo, expand in vitro and their therapeutic use for bone marrow transplantation. Read more