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protein aggregation PhD Projects, Programs & Scholarships

We have 23 protein aggregation PhD Projects, Programs & Scholarships

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  (BBSRC DTP) Elucidating the responses to nascent protein misfolding and aggregation stress
  Prof C M Grant, Prof S Hubbard, Prof M Ashe
Application Deadline: 31 January 2019
The aim of this study is to characterize the proteins that aggregate during nascent protein misfolding and to investigate how cells mitigate the damaging effects of aggregate formation.
  Characterising surface properties of protein biopharmaceutical molecules
  Dr A Golovanov, Dr J Warwicker
Applications accepted all year round
Protein biologicals have great potential for the effective treatment of a wide range of diseases. However, aggregation and instability are inherent issues with all protein pharmaceuticals, which is a problem that can limit their utility and developability.
  A novel class of excipients for stabilizing protein therapeutics
  Dr R Curtis, Dr J Warwicker
Applications accepted all year round
Biopharmaceutical proteins constitute a growing proportion of the drug catalogue for virtually all major pharmaceutical companies.
  Deciphering Roles of SUMOylation in mini-Human Brains in Health and Disease
  Dr C Guo, Dr S Brown
Application Deadline: 23 January 2019
Neurodegenerative disorders and cerebral ischemia are incurable conditions, imposing tough medical challenges and a substantial economic burden on health services.
  Deep Learning / Bioinformatics Approach for Protein-Protein Interaction Prediction
  Dr JC Nebel
Applications accepted all year round
Since most molecular processes rely on protein–protein interactions PPIs), knowledge of those interactions is extremely valuable for biomedical research and drug design.
  Predicting the conversion of LRRK2 carriers to Parkinson disease: the role of blood and CSF biomarkers
  Dr E Sammler
Applications accepted all year round
Parkinson’s disease is a progressive neurodegenerative disease affecting up to 1:500 people over the age of 50 years.1 The risk of developing Parkinson’s…
  Understanding Neuroinflammation through advanced in vitro 3D modelling using human Pluripotent Stem Cells
  Dr S Cowley, Prof W S James
Application Deadline: 25 January 2019
Microglia - brain-resident macrophages - carry out homeostatic surveillance functions in the brain, clearing dying cells, extracellular debris, and pruning synapses during development.
  Real-time monitoring of biopharmaceutical aggregation under flow by fluorescence
  Dr R Curtis, Dr C Pereira da Fonte, Dr A Pluen
Applications accepted all year round
Biopharmaceutical proteins constitute a growing proportion of the drug catalogue for virtually all major pharmaceutical companies.
  Impact of 14-3-3 protein on the formation of protein aggregates involved in neurodegenerative diseases
  Dr J Hritz, Prof V Bryja, Dr J Pribyl
Application Deadline: 3 February 2019
The neuronal cells of patients suffering from neurodegenerative diseases are characteristic by possession of aggregates of several proteins such as tau and Abeta protein.
  Expressing the key photoprotective protein of diatom algae, LHCX1, in higher plants
  Prof A Ruban, Dr G Hanke
Application Deadline: 31 January 2019
Significance and timeliness. Photosynthetic organisms face rapid fluctuations in light intensity. High light is harmful, resulting in reduction in plant productivity [1].
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