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protein expression PhD Projects, Programs & Scholarships

We have 157 protein expression PhD Projects, Programs & Scholarships

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  Optimisation of gene expression routes for heterologous protein expression in CHO cells
  Dr P Mitchell
Applications accepted all year round
CHO cells are commonly used as a vehicle for the production of heterologous proteins in the biopharmaceutical industry. We are currently using gene knock down and knock in approaches to increase the expression level of target recombinant proteins for potential use in industrial scale applications.
  (BBSRC DTP CASE) A synthetic biology approach to develop bacterial protein expression tools
  Prof J Micklefield, Dr A Green
Application Deadline: 31 January 2019
Streptomyces and related bacteria possess diverse biosynthetic pathways that produce a wide array of bioactive natural compounds including antibiotics, anti-cancer agents and other therapeutically important molecules.
  Investigating the effect of telomere length on endothelial cell function
  Dr V Codd, Prof NJ Samani
Application Deadline: 27 January 2019
Telomeres are protein bound DNA repeat structures at the ends of eukaryotic chromosomes, Telomere length (TL) has been proposed as a marker of biological ageing and shorter TL associates with several age related diseases, including coronary artery disease (CAD).
  Insights into Transcription/Translation in Prostate Cancer through analyses of novel data sets
  Prof A Lynch
Applications accepted all year round
Approximately one in eight men will be diagnosed with prostate cancer (PCa) in his life, while a substantially higher proportion of men would show evidence of PCa under histopathological examination.
  The Enhancement of Animal Health/Nutrition Related Enzymes using Genome Editing
  Dr L Coffey, Dr O O'Donovan
Application Deadline: 25 January 2019
Post summary. Applications are invited for a PhD position funded by the WIT Co-Fund PhD Scholarship and Alltech Ireland, for a 4-year research project “The Enhancement of Animal Health/Nutrition Related Enzymes using Genome Editing”.
  Airway, Liver and Muscle Gene Transfer to Create Therapeutic Protein Factories: utilising experience of in vivo gene transfer and/or in vivo gene editing to understand and manipulate the factors required for effective expression and secretion of therapeutic proteins
  Dr S Hyde, Dr D Gill
Application Deadline: 26 July 2019
We are focusing on strategies to deliver therapeutics via in vivo delivery of gene transfer vectors to generate ectopic “protein factories” capable of secreting therapeutic proteins into both the lung lumen and the systemic circulation.
  Using state-of-the-art proteomics to study the cellular and extracellular protein composition in human kidney disease; identification of novel biomarkers and bioactive drug targets in IgA Nephropathy
  Dr A Didangelos, Prof J Barratt
Applications accepted all year round
One of the key pathological characteristics of IgA nephropathy (IgAN) is the maladaptive and chronic accumulation and remodelling of the extracellular matrix (ECM) in affected glomeruli leading to fibrosis and progressive loss of function.
  (BBSRC DTP) Probing Regulatory Networks setting Notch signalling levels in vivo in Drosophila and Zebrafish.
  Dr M Baron, Dr S Herbert, Prof S Hubbard
Application Deadline: 31 January 2019
Development of organisms and maintenance of healthy tissues depends on proper control of cell to cell communication networks that control cell fate and behaviour.
  Analysing the factors that regulate expression of blood-brain barrier drug transporter proteins
  Dr J L Penny, Dr C Demonacos
Applications accepted all year round
In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain.
  Interplay between the translation of upstream open reading frames and ribosome nascent chain-associated factors to control gene expression in eukaryotic cells
  Dr M Pool, Prof G D Pavitt
Applications accepted all year round
Eukaryotic mRNAs typically contain one open reading frame that is translated into protein. However many mRNAs contain additional upstream ORFs (uORFs) that regulate protein expression by controlling the flow of ribosomes to the main ORF, often by regulated reinitiation.
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