We have 244 proteins PhD Projects, Programmes & Scholarships

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proteins PhD Projects, Programmes & Scholarships

We have 244 proteins PhD Projects, Programmes & Scholarships

Modulation of host immune response by secreted proteins from parasitic worms

Background. To establish chronic infection, parasitic worms manipulate their mammalian hosts’ immune system. This immune modulation is often mediated by excreted or secreted parasite glycoproteins (ES proteins). Read more

How does the dynamic intra-membrane aggregation of phage lysis proteins kill bacterial pathogens?

This is an interdisciplinary project. It will provide a unique opportunity to obtain training in a wide range of interdisciplinary skills, including protein engineering techniques, protein purification, atomic force microscopy, neutron reflection and scattering as well as molecular dynamics simulations. Read more

Understanding interactions of proteins with polymer-coated nanoparticles

Introduction. Polymer-coated nanoparticles are promising drug delivery vehicles. Multiple functionalities can be embedded into the nanoparticle structure to enable uptake of the drug-like molecules, their targeted delivery and controlled release. Read more

Decoding the epigenetic mechanisms of drug resistance in aggressive breast cancers

Breast cancers pose a major health burden to modern world as being the most common cancer in women. Estrogen receptor (ER), the classical marker of 70% these cancers, is the nuclear receptor important for cancer progression. Read more

Chemical modification of proteins via metal-mediated processes

Chemically modified proteins can be used to understand, treat, and diagnose disease. However, relatively few chemical reactions can be used to modify proteins, severely limiting the diversity and applications of new technologies. Read more

Cryo-EM Structure and Function of Membrane Proteins Involved in Human Diseases

While membrane proteins only make up around 20% of the proteome, they constitute around 60% of drug targets. However, high resolution structural information is severely lacking for them, with only about 2% of the structures deposited in the public protein database (PDB) being annotated as membrane proteins. Read more

Engineering Ice-Binding Proteins

Ice-binding proteins are produced by extremophiles to help them survive in the worlds coldest places. They have many potential applications, from the storage of cells/tissue to transport infrastructure. Read more

Design of metamorphic proteins for stimuli-responsive nanomaterials

Project Description. The classic structure-function paradigm of proteins contends that a protein exhibits a single well-defined folded structure that gives rise to its biological function. Read more

Developing novel targeted therapeutic approaches through induced-proximity of proteins

Protein post-translational code is at the heart of protein function and signal transduction in cells. Enzymes catalyse the addition or removal of post-translational modifications (PTM), such as phosphorylation, methylation, acetylation, and ubiquitylation, on proteins. Read more

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