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proteins PhD Projects, Programs & Scholarships

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  Structure, regulation and dynamics of small G proteins and their interactions with membranes and effector proteins
  Dr H Mott
Applications accepted all year round
Our lab are interested in cell signalling via small G proteins of the Ras superfamily. We use a range of biochemical, biophysical and structural approaches to understand these fascinating proteins, which are involved in multiple cellular processes and are often deregulated in diseases such as cancer.
  Multimerisation of ELAV/Hu proteins – a key mechanism ensuring specificity for RNA recognition in health and disease
  Dr M Soller, Dr T Knowles
Applications accepted all year round
Aims. Determine the structure of the ELAV dodecameric complex bound to target RNA by cryoEM and functionally probe interaction interfaces in vitro and in vivo in transgenic Drosophila models for neurodegeneration and cancer.
  BBSRC MIBTP - Identification of pathways deregulating neuronal ELAV/Hu RNA binding proteins and alternative splicing in neurodegeneration
  Research Group: BBSRC MIBTP
  Dr M Soller, Dr M Tomlinson
Applications accepted all year round
ELAV/Hu proteins comprise a family of highly conserved neuronal RNA binding proteins important for the development of the nervous system and for neuronal functions.
  Structure and function of key ABC Transporters in health and disease
  Prof L Carpenter, Dr H de Wet
Application Deadline: 25 January 2019
Human ABC transporters are a family 52 integral membrane proteins that transport diverse molecules across cell membranes. Mutations in ABC transporters causes a range of diseases, including diabetes (ABCC8 and ABCC9), cystic fibrosis (ABCC7, CFTR) and blindness (ABCA4).
  The role of matrix interactions in regulating the SPARC family of matricellular proteins.
  Dr N Hill, Dr A Munasinghe
Applications accepted all year round
The SPARC family of matricellular proteins determine the way in which cells respond to their extracellular environment. SPARC family proteins interact with a range of binding partners, including matrix proteins (1).
  Analysis of Heparin Binding Proteins and the Supramolecular Structure of Extracellular Matrix
  Prof D G Fernig, Prof C E Eyers
Applications accepted all year round
Changes in heparan sulfate structure and location have long been associated with Alzheimer’s disease, but the functional significance of this has remained elusive.
  Protein quality control and neurodegenerative disease - to test the hypothesis that BAG6 contributes to the quality control of a range of disease-linked proteins in the cytosol
  Dr L Swanton, Prof S High
Applications accepted all year round
Misfolded proteins represent a continuous threat to cell viability, which if allowed to accumulate can disrupt cellular function and induce cell death [1].
  Regulatory roles for ribosome-associated proteins in protein synthesis
  Prof G D Pavitt, Dr M Pool
Applications accepted all year round
Protein synthesis is a highly-conserved, dynamic and tightly controlled process that is central to the activity of all cells. All phases of translation can be controlled.
  (BBSRC DTP)Understanding structure and function of the mechanosensors talin and vinculin
  Dr C Ballestrem, Prof C Baldock, Dr A Roseman
Application Deadline: 31 January 2019
Any aberration in the cells’ ability to sense their environment leads to severe health deficiencies including cancer, deficiencies in wound-healing and inflammation.
  Unveiling the nanomechanical properties of the LINC complex proteins with single molecule resolution
  Prof S Garcia Manyes
Application Deadline: 15 March 2019
Mechanical forces are involved in many physiological processes. While most of the current work in mechanotransduction has focused on the function of focal adhesion proteins and the actin cytoskeleton, the mechanical role of intracellular and nuclear proteins remains rather elusive.
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