Quantitative Allele-Specific Proteomics in Drug Metabolism and Disposition
Dr J Barber, Dr B Achour, Prof A Rostami
Applications accepted all year round
The effective dose of a drug is subject to considerable inter-individual variation because the enzymes that metabolise drugs and the proteins that transport them in and out of cells exist, in many cases, in different polymorphic forms and are expressed in varying concentration.
Mapping the circadian clock-dependent regulation of the secretory pathway
Prof K E Kadler, Dr Q-J Meng
Applications accepted all year round
The protein secretory pathway in cells comprises a series of membranous compartments and transport vesicles that the cell uses to synthesise, post-translationally modify, and move proteins for delivery to the plasma membrane or for secretion to the extracellular matrix.
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Molecular dissection of activity-dependent neuronal signalling pathways using quantitative proteomics
