quality control PhD Projects, Programmes & Scholarships

BBSRC NLD Doctoral Training Partnership: Quality control mechanisms of mRNA biogenesis

University of Liverpool Faculty of Health and Life Science

Background. Transcription, the first step in gene expression, underpins life. Elimination of non-functional transcripts is vital for proper gene expression and of paramount importance to cellular homeostasis. Read more

Supervisors: Dr M Papamichos Chronakis, Dr L Russell, Dr A Viñuela

15 January 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Protein maturation, quality control, and disease

Medical Research Council (Cambridge) Laboratory of Molecular Biology

Cells are amazingly organized entities. Their resident proteins, nucleic acids, and small molecules are assembled into functional modules and organized among numerous membrane-bound cellular compartments. Read more

Supervisor: Dr R Hegde

5 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Mechanisms of protein quality control in health and disease

University of Oxford Sir William Dunn School of Pathology

Accumulation of misfolded proteins and aberrant protein aggregates are hallmarks of a wide range of pathologies such as neurodegenerative diseases and cancer. Read more

Supervisor: Prof P Carvalho

1 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Boosting protein quality control

Medical Research Council (Cambridge) Laboratory of Molecular Biology

The deposition of misfolded proteins is a defining feature of many age-dependent human diseases, including the increasingly prevalent neurodegenerative diseases. Read more

Supervisor: Dr A Bertolotti

5 December 2023 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials

The University of Manchester Faculty of Biology, Medicine and Health

Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function. Read more

Supervisors: Dr V Liu, Dr L Swanton

Year round applications PhD Research Project Self-Funded PhD Students Only

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The role of mitochondrial membrane remodelling in controlling mtDNA levels and heteroplasmy

Medical Research Council (Cambridge) Mitochondrial Biology Unit

Mitochondria are dynamic organelles generating a specific network by membrane remodeling events according to cellular needs1. Mitochondria contain multiple copies of their own genome, mtDNA, a circular molecule that encodes for 13 proteins involved in energy production through oxidative phosphorylation. Read more

Supervisors: Dr Julien Prudent, Dr M Minczuk

4 January 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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The role of mitochondrial membrane remodelling in controlling mtDNA levels and heteroplasmy

University of Cambridge MRC Mitochondrial Biology Unit

Mitochondria are dynamic organelles generating a specific network by membrane remodeling events according to cellular needs1. Mitochondria contain multiple copies of their own genome, mtDNA, a circular molecule that encodes for 13 proteins involved in energy production through oxidative phosphorylation. Read more

Supervisors: Dr Julien Prudent, Dr M Minczuk

4 January 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Integrated omics approach to psychiatric disorders

University of Bradford Faculty of Life Sciences

Research Group: Chemistry and Biosciences

In psychiatry, the selection of antipsychotics and antidepressants is led by a trial-and-error approach. The prescribing of these medications is complicated by sub-optimal efficacy and high rates of adverse drug reactions (ADRs). Read more

Supervisors: Prof K Poterlowicz, Dr S McLean

Year round applications PhD Research Project Self-Funded PhD Students Only

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Chaperones and the response to protein misfolding stress

The University of Manchester Faculty of Biology, Medicine and Health

Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more

Supervisors: Prof C M Grant, Prof M Ashe

Year round applications PhD Research Project Self-Funded PhD Students Only

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BBSRC NLD Doctoral Training Partnership: Critical evaluation of mitophagy, mitochondrial dysfunction and senescence axis

Newcastle University Faculty of Medical Sciences

Many types of cells become senescent as a response to a variety of stressors, and show distinct senescence phenotype such as persistent DNA damage, mitochondrial dysfunction, increased levels of reactive oxygen species (ROS) and pro-inflammatory cytokine. Read more

Supervisors: Dr S Miwa, Dr V Korolchuk, Prof A McArdle

15 January 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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3DBioFractal: A model multi-organ culture platform for tissue engineering and engineering biology

University College London London Interdisciplinary Biosciences Consortium (LIDo)

The limitations of animal models in bioscience research and whether they inform accurately on human physiology, pathology and therapies is well understood. Read more

Supervisors: Prof G Thomas, Dr S Goldrick

10 January 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Identifying critical pathways regulating autoimmunity in immuno-oncology and arthritis patients. Short title: IPADS (Immune PAthways for Drug Side-effects)

The University of Manchester Faculty of Biology, Medicine and Health

Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies (inc. Read more

Supervisors: Dr S Viatte, Prof A Barton, Mr P Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Monitoring Scotland’s fresh waters from space: re-engineering the state-of-art using artificial intelligence.

University of Stirling School of Biological & Environmental Sciences

Scotland’s freshwater ecosystems are under significant pressure from a range of stressors including inputs of diffuse pollution from agriculture, wastewater spillages from combined sewer outflows, and the increasing occurrence of hydroclimatic extremes (Marsden & Mackay, 2001). Read more

Supervisors: Dr P Hunter, Prof A N Tyler, Dr R O'Donnell

5 January 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Heat shapes plant growth - unravelling crosstalk between temperature and hormone signalling pathways in the control of leaf development

University of Dundee School of Life Sciences

Ambient temperature has profound effects on almost all aspects of plant development, from the onset of seed germination and seedling establishment to flower and fruit production, and thereby also impacts crop quality and yield. Read more

Supervisor: Dr M Balcerowicz

15 March 2024 PhD Research Project Self-Funded PhD Students Only

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BBSRC NLD Doctoral Training Partnership: Boosting physiological collagen synthesis and regulating localised collagen over-production in ageing

University of Liverpool Faculty of Health and Life Science

The United Nations has identified ageing as a key global issue, with an ageing population having implications across society including health, finance, housing and families. Read more

Supervisors: Dr E Laird, Dr A Benham

15 January 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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We have 272 quality control PhD Projects, Programmes & Scholarships

quality control PhD Projects, Programmes & Scholarships

We have 272 quality control PhD Projects, Programmes & Scholarships

BBSRC NLD Doctoral Training Partnership: Quality control mechanisms of mRNA biogenesis

Protein maturation, quality control, and disease

Mechanisms of protein quality control in health and disease

Boosting protein quality control

Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials

The role of mitochondrial membrane remodelling in controlling mtDNA levels and heteroplasmy

The role of mitochondrial membrane remodelling in controlling mtDNA levels and heteroplasmy

Integrated omics approach to psychiatric disorders

Chaperones and the response to protein misfolding stress

BBSRC NLD Doctoral Training Partnership: Critical evaluation of mitophagy, mitochondrial dysfunction and senescence axis

3DBioFractal: A model multi-organ culture platform for tissue engineering and engineering biology

Identifying critical pathways regulating autoimmunity in immuno-oncology and arthritis patients. Short title: IPADS (Immune PAthways for Drug Side-effects)

Monitoring Scotland’s fresh waters from space: re-engineering the state-of-art using artificial intelligence.

Heat shapes plant growth - unravelling crosstalk between temperature and hormone signalling pathways in the control of leaf development

BBSRC NLD Doctoral Training Partnership: Boosting physiological collagen synthesis and regulating localised collagen over-production in ageing

We have 272 quality control PhD Projects, Programmes & Scholarships

quality control PhD Projects, Programmes & Scholarships

We have 272 quality control PhD Projects, Programmes & Scholarships

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