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We have 10 rat PhD Projects, Programs & Scholarships

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  (MRC DTP) Hippocampal-prefrontal cortex network dysfunction in a neurodevelopmental model of schizophrenia
  Dr M Montemurro, Dr J Gigg, Prof J Neill
Application Deadline: 15 November 2019

Funding Type

PhD Type

Drug discovery in schizophrenia is broken. Patients only have access to dopaminergic drugs from the 1950s that are ineffective for many and produce severe side effects in responders.
  The synthetic littermate project: How do natural experiences shape the functional organisation of the developing brain?
  Dr SP Wilson, Prof AJ Prescott
Applications accepted all year round

Funding Type

PhD Type

How do natural experiences shape the functional organisation of the developing brain? To address this question directly, we have been developing a novel robotic technology - the synthetic littermate (or ’surrogate’).
  Oral delivery of insulin for diabetes therapy: Development and evaluation of insulin loaded polymer/lipid based carrier systems
  Dr A Vangala
Applications accepted all year round

Funding Type

PhD Type

Diabetes is a chronic metabolic disorder that affects nearly 500 million people worldwide. Its hallmark feature, hyperglycaemia is caused due to insulin deficiency and/or resistance.
  Deciphering the neural code of the hippocampus
  Dr M Montemurro, Dr J Gigg
Applications accepted all year round

Funding Type

PhD Type

Background. The brain processes and stores information about our lives and the world that surrounds us. At the neural scale, information is encoded through the precise timing of activity across populations of neurons.
  Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease
  Dr M Harte, Prof J Neill
Applications accepted all year round

Funding Type

PhD Type

Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist.
  Understanding the aetiology of diabetic neuropathy
  Dr N Gardiner, Dr R Unwin
Applications accepted all year round

Funding Type

PhD Type

Diabetic neuropathy is a common secondary complication of diabetes mellitus which affects around 50% of all patients with diabetes - impacting on health, wellbeing and quality of life.
  Eukaryotic gene expression: understanding the role of UPF1 in global mRNA processing and amyotrophic lateral sclerosis (ALS)
  Dr S Brogna
Applications accepted all year round

Funding Type

PhD Type

This project’s specific objective is to study the molecular role(s) that the RNA helicase UPF1 plays in RNA processing. UPF1 is a key player in nonsense-mediated mRNA decay (NMD), it is universally conserved in eukaryotes and is essential to the development of many organisms [1].
  Therapeutic resolution of pulmonary arterial hypertension (PAH) by natural products
  Research Group: Pharmacology and Experimental Therapeutics
  Dr T Nasim, Prof C Wright
Applications accepted all year round

Funding Type

PhD Type

Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death.
  Targeting antiretroviral drugs to the gut-associated lymphoid tissues for improved treatment of HIV/AIDS
  Dr P Gershkovich
Applications accepted all year round

Funding Type

PhD Type

"Gut-associated lymphoid tissue (GALT) is an anatomical reservoir of HIV, setting a barrier for strategies aimed at HIV eradication.
  Identifying inhibitors specific to the OPG-kinome: towards novel treatments for Pulmonary Arterial Hypertension (PAH).
  Prof A Lawrie, Dr R Thompson
Applications accepted all year round

Funding Type

PhD Type

Background. Pulmonary arterial hypertension (PAH) is a fatal progressive disease. Median life expectancy in untreated PAH patients is 2.8 years.
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