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receptor PhD Projects, Programs & Scholarships

We have 95 receptor PhD Projects, Programs & Scholarships

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  Characterisation of the neuronal receptor for soluble amyloid precursor protein: a route to new therapeutic targets for Alzheimer’s disease
  Prof N Hooper, Prof M J Humphries
Applications accepted all year round

Funding Type

PhD Type

Alzheimer’s disease (AD) is the commonest form of dementia for which currently there is no means of stopping or even slowing the disease.
  Identification of mlm receptor antagonists for treatment of cancer
  Dr R Foster
Applications accepted all year round

Funding Type

PhD Type

Recent high impact publications have identified antagonism of the mlm receptor as a possible target for treatment of cancer. The native ligand of the receptor has been linked to cell proliferation which has been proven to be as a result of increased nitric oxide (NO) concentration.
  Interleukin-36 and Its Receptor
  Dr M Nicklin
Applications accepted all year round

Funding Type

PhD Type

I am exploring how the pro-inflammatory cytokine interleukin-36 can become activated and the structural features of the receptor and the cytokine that allow activation to be recognised in vivo.
  Glutamatergic pharmacology and receptor modifications underlying cognitive function in a rodent model of schizophrenia
  Research Group: Pharmacology and Experimental Therapeutics
  Dr K Pors, Dr S McLean, Dr S Kantamneni
Applications accepted all year round

Funding Type

PhD Type

Cognitive deficits are recognised as being a core symptom of psychiatric disorders including schizophrenia.
  Structural insights into ligand binding and channel gating in ATP-gated P2X7 receptor
  Research Group: School of Biomedical Sciences
  Dr L H Jiang, Dr S Muench
Applications accepted all year round

Funding Type

PhD Type

P2X7 receptor, belonging to the ATP-gated ion channel P2X receptor family, exhibits distinct functional and pharmacological properties that are crucial for its role in innate immunity and inflammatory diseases and cancers (Jiang et al., 2013; Caseley et al., 2014; Roger et al., 2014; Wei et al., 2018).
  Identification of the Trypanosoma brucei transferrin receptor-recognition site of transferrin (SteverdingDU19SF)
  Dr D Steverding
Application Deadline: 31 May 2020

Funding Type

PhD Type

The transferrin receptor of the protozoan parasite Trypanosoma brucei (TbTfR) is a heterodimeric protein complex encoded by two expression site associated genes, ESAG6 and ESAG7, which shows no homology to the homodimeric human transferrin receptor (hTfR).
  Molecular Modelling of P2X receptor agonism and antagonism
  Dr R Schmid
Application Deadline: 7 June 2020

Funding Type

PhD Type

P2X receptors (P2XRs) form a family of ligand-gated ion channels activated upon binding of extracellular ATP (for review see [1]).
  Novel G Protein-Coupled Receptor interactions with RAMP accessory proteins
  Dr G Richards, Prof T Skerry
Applications accepted all year round

Funding Type

PhD Type

Cell signalling is critical to multicellular organisms and underlies physiology and diseases. Understanding of the ways cells sense and respond to hormones and growth factors is a constantly-evolving field.
  Involvement of P2X7 receptors in cancer
  Dr E Polycarpou
Applications accepted all year round

Funding Type

PhD Type

The P2X receptors are a family of ligand-gated receptor channels activated by ATP and other extracellular nucleotides. A member of this family, the P2X7 purinergic receptor has been shown to play a crucial role in various physiological and pathophysiological processes.
  Ca2+ signalling in neurodegeneration and Alzheimer’s disease
  Research Group: School of Biology
  Prof I A Hope
Applications accepted all year round

Funding Type

PhD Type

Human variants of the ryanodine receptor, the main intracellular calcium ion channel, could be responsible for Alzheimer’s disease.
  Understanding how the bitter taste receptor, T2R38, regulates the intestinal epithelium - a study from microbiota to the intestinal epithelium
  Research Group: Biomedical Research Group
  Dr H Chichger
Applications accepted all year round

Funding Type

PhD Type

Research Group. Biomedical Research Group. https://www.anglia.ac.uk/science-and-engineering/research/institutes-and-groups/biomedical.
  Post-transcriptional regulation of transferrin receptor expression in Trypanosoma brucei
  Dr C Tiengwe
Applications accepted all year round

Funding Type

PhD Type

The goal of this project is to understand how. Trypanosoma brucei. controls expression of iron regulatory proteins in response to changes in intracellular iron.
  Targeting the Gas6-TAM receptor signalling pathway in cancer
  Dr S Hafizi
Applications accepted all year round

Funding Type

PhD Type

Applications are invited for a self-funded 3 year full-time PhD project, to commence in October 2019 or February 2020. The PhD will be based in the School of Pharmacy and Biomedical Sciences and will be supervised by Dr Sassan Hafizi.
  Myocardial biology with a specific focus on the mechanisms underlying cardiac fibrosis and atrial fibrillation
  Dr S Reilly, Prof C Redwood, Assoc Prof M Lei
Application Deadline: 24 July 2020

Funding Type

PhD Type

Cardiac fibrosis is a hallmark histological feature of structural changes in the myocardium associated with virtually all cardiac diseases (e.g., heart failure, hypertension, atrial fibrillation and myocarditis).
  Accurate energy evaluation of receptor-ligand interaction
  Prof P Popelier, Dr S De Visser
Applications accepted all year round

Funding Type

PhD Type

Drug design routinely uses existing computational methods to evaluate the interaction energy between receptor (protein) and ligand (drug) in molecular docking.
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