Cleavage of receptor protein tyrosine phosphatases: mechanisms and consequences
Dr D Cunningham, Dr M Tomlinson
6 January 2019
This project aims to establish a new paradigm in cell signalling by showing how cell surface-anchored phosphatases can be converted into distinct cytoplasmic phosphatases by a cleavage event, thus effectively doubling a cell’s phosphatase repertoire.
Targeting the P2X7 purinergic receptor in melanoma (STOKESLU19SF)
Dr L Stokes, Dr C Morris
31 May 2019
There is much research into trying to regain control of cell proliferation or cell death (apoptosis) in cancer. Different strategies exist to do this and a multitude of individual receptor targets are being identified in tumour cell lines and primary cells.
Involvement of P2X7 receptors in cancer
Dr E Polycarpou
Applications accepted all year round
The P2X receptors are a family of ligand-gated receptor channels activated by ATP and other extracellular nucleotides. A member of this family, the P2X7 purinergic receptor has been shown to play a crucial role in various physiological and pathophysiological processes.