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We have 72 receptor PhD Projects, Programmes & Scholarships

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receptor PhD Projects, Programmes & Scholarships

We have 72 receptor PhD Projects, Programmes & Scholarships

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Mechanistic insights into Family B G-protein-coupled receptors (GPCRs) using SMA-like polymers

Calcitonin receptor-like receptor (CLR) is an important family B G-protein-coupled receptor (GPCR) that is significantly under-explored, despite huge therapeutic potential. Read more

Use of a novel conjugation approach to generate a long-acting growth hormone receptor antagonist

Targeting the growth hormone (GH) signalling pathway could be an effective therapeutic approach for certain types of cancer. However, a lack of access to therapeutics that target GH or the GH receptor has hindered preclinical studies in this field. Read more

Investigating the role of P2X7 receptor intracellular domains in cell signalling

Project description. P2X7 receptors are ion channels that are found on the surface of immune cells, where they respond to the binding of extracellular ATP, a damage signal released by dying cells in infection and injury. Read more

Molecular characterisation of scavenger receptor ligand binding.

Scavenger receptors have been identified as being important in Human disease and normal physiological responses. Scavenger receptors are a large family of cell surface receptors that are expressed ubiquitously. Read more

Investigating platelet signalling and thrombus formation

We are seeking talented, motivated students with a passion for research in cardiovascular cell biology to work in the group of Dr Natalie Poulter, which focuses on understanding how platelets become activated and form a thrombus. Read more

Characterisation of adrenoceptor and muscarinic receptor subtypes coupled to potassium channels in chondrocytes from bovine cartilage

  Research Group: Chemistry and Biosciences
Several outward potassium currents have been identified in bovine chondrocytes (review Mobasheri et al. 2012). These include ATP-sensitive and a Calcium-activated potassium currents (Sanches & Lopez-Zapata, 2011). Read more

Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam

Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response. Read more

Mechanisms underlying the effects of activated protein C (APC) in cardiac muscle

  Research Group: Chemistry and Biosciences
APC is an anticoagulant enzyme that also exerts antithrombotic, anti-inflammatory, antiapoptotic and a variety of other cytoprotective effects in different tissues, where the mechanism of action is thought to involve the endothelial protein C receptor (EPCR) and a protease activated receptor (PAR). Read more

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