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receptor PhD Projects, Programmes & Scholarships
We have 97 receptor PhD Projects, Programmes & Scholarships
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Characterisation of the neuronal receptor for soluble amyloid precursor protein: a route to new therapeutic targets for Alzheimers disease
Alzheimer’s disease (AD) is the commonest form of dementia for which currently there is no means of stopping or even slowing the disease. Read more
Therapeutic targeting of chemokines in inflammation
Protein interactions underlie most biological processes but are challenging to target using small molecule drugs. Many protein interactions are mediated by short-linear-interacting motifs (SLiMs) that range from 3-12 amino acid residues (1, 2). Read more
Understanding how glucagon-like peptide-1 (GLP1) and gastric inhibitory polypeptide (GIP) receptors contribute to metabolism in complex tissues.
Our labs are focused on developing and using novel technologies to address challenging problems in cellular metabolism, with translational relevance for patients. Read more
4-year PhD Studentship: Control of neuronal differentiation and ciliogenesis through mineralocorticoid receptor (MR) – Regulatory Factor X (RFX) interaction in embryonic and adult neurogenesis
Glucocorticoid hormones (GCs) are of critical importance for health[1]. They bind to two receptor types in the hippocampus. the mineralocorticoid (MR) and glucocorticoid receptor (GR) which act as ligand-dependent transcription factors[2-4]. Read more
Molecular Modelling of P2X receptor function
P2X receptors (P2XR) are a family of ligand-gated ion channels. P2XRs are activated upon binding of extracellular ATP and allow the influx of small cations after channel opening. Read more
Involvement of P2X7 receptors in cancer
The P2X receptors are a family of ligand-gated receptor channels activated by ATP and other extracellular nucleotides. A member of this family, the P2X7 purinergic receptor has been shown to play a crucial role in various physiological and pathophysiological processes. Read more
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Identifying NMDA receptor complex interactomes of epilepsy associated genetic variants using BioID( Ref: WD_2022_21_WSCH)
Post Summary. Applications are invited from suitably qualified candidates interested in pursuing a PhD in the area of molecular biology on a recently funded research project within the PMBRC at WIT. Read more
Allosteric targeting of the prostaglandin receptor EP2 to promote neuroprotection against excitoxicity
Research Group:
Wellcome-Wolfson Institute for Experimental Medicine
Excitotoxicity occurs upon brain injury or neurodegenerative diseases and exacerbates associated neuronal damages. The prostaglandin E2 receptor (EP2) has neuroprotective properties against excitotoxicity and novel molecules increasing EP2 activity have been recently discovered. Read more
Allosteric targeting of the prostaglandin receptor EP2 to promote neuroprotection against excitoxicity
Excitotoxicity occurs upon brain injury or neurodegenerative diseases and exacerbates associated neuronal damages. The prostaglandin E2 receptor (EP2) has neuroprotective properties against excitotoxicity and novel molecules increasing EP2 activity have been recently discovered. Read more
Characterising Receptor and Ion Channels Signaling in 3D cultures
The molecular mechanisms that regulate receptors and receptor are complex and are often studied in two-dimensional cell culture systems. Read more
Unravelling the molecular biology of UTI phage cocktails
Project highlights. Identifying phage receptor binding proteins that allow clinically useful phages to bind to their bacterial hosts. Read more
Understanding tumour relapse in estrogen receptor positive breast cancer via machine learning
PhD opportunity in the CDT . AI for Healthcare. , under the supervision of Dr Barbara Bravi (Department of Mathematics) and Prof Luca Magnani (Surgery and Cancer). Read more
Insect odorant receptor electronic sensors
Insect odorant receptors are a unique class of protein complexes evolved for odour sensing, with strong potential for electronic nose technology. Read more
Preparing the acid bath: how epidermal growth factor receptor (EGFR) controls its own down-regulation
Signalling by cell surface receptors determines nearly every aspect of the cell’s response to its environment. Endosomes are hubs for regulating these signalling pathways. Read more
Probing Viral Receptor-Glycan Interactions using Polyvalent Multifunctional Glycan-Nanoparticle
Research Group:
School of Chemistry
Multivalent viral receptor-glycan interactions are central to viral infection and immune response regulation. However, the underpinning structural mechanisms are often poorly understood, due to a lack of effective probes for such complex, multimeric and flexible proteins. Read more