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receptor regulation PhD Projects, Programs & Scholarships

We have 35 receptor regulation PhD Projects, Programs & Scholarships

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  Understanding the role of the novel apelin receptor ligand apela in the regulation of neuroendocrine function.
  Dr A O'Carroll
Applications accepted all year round
The apelin receptor APJ (1) was first identified as an orphan GPCR, with closest identity to the angiotensin II receptor, type AT1a.
  Understanding the role of the novel apelin receptor ligand Apela in the regulation of neuroendocrine function.
  Dr A O'Carroll, Dr S J Lolait
Applications accepted all year round
The apelin receptor APJ (1) was first identified as an orphan GPCR, with closest identity to the angiotensin II receptor, type AT1a.
  Functional Selectivity and the Regulation of Receptor-Activated Signaling Pathways
  Dr G Cottrell, Dr D Widera, Dr S Amadesi, Dr A McNeish
Applications accepted all year round
The molecular mechanisms that regulate receptors and receptor-activated signaling pathways in the cardiovascular and nervous systems are complex.
  Cleavage of receptor protein tyrosine phosphatases: mechanisms and consequences
  Dr D Cunningham, Dr M Tomlinson
Application Deadline: 6 January 2019
This project aims to establish a new paradigm in cell signalling by showing how cell surface-anchored phosphatases can be converted into distinct cytoplasmic phosphatases by a cleavage event, thus effectively doubling a cell’s phosphatase repertoire.
  MRC Precision Medicine DTP: Genome-wide, gene-specific patterns of glucocorticoid-receptor co-regulators critical for growth and skeletal development
  Research Group: The Roslin Institute
  Prof C Farquharson, Prof T Freeman, Prof S Faisal Ahmed, Prof L Savendahl
Application Deadline: 7 January 2019
Background. Glucocorticoids (GCs) are a class of steroid hormones that bind and activate the intra-cellular GC receptor (GR), and regulate transcription of many genes that govern the effects of GCs.
  Circadian control of energy metabolism and inflammation: Employing a range of approaches to address the physiological importance of the circadian:nuclear receptor system, ranging from population genetics, experimental medicine studies, CRISPR engineered mice, and cell biology
  Prof D Ray
Application Deadline: 11 January 2019
Employing a range of approaches to address the physiological importance of the circadian:nuclear receptor system, ranging from population genetics, experimental medicine studies, CRISPR engineered mice, and cell biology.
  Targeting the P2X7 purinergic receptor in melanoma (STOKESLU19SF)
  Dr L Stokes, Dr C Morris
Application Deadline: 31 May 2019
There is much research into trying to regain control of cell proliferation or cell death (apoptosis) in cancer. Different strategies exist to do this and a multitude of individual receptor targets are being identified in tumour cell lines and primary cells.
  Heme regulation of signalling at potassium channels in the cardiovascular system
  Dr N Storey, Dr N W Davies
Application Deadline: 6 January 2019
Ion channels in the smooth muscle of the cardiovascular system control blood pressure and cardiac contractility through changes in their membrane potential.
  (BBSRC DTP) Structure and functional study to probe the mechanism of BMP regulation by the chordin family
  Prof C Baldock, Prof H Ashe, Dr A Roseman
Application Deadline: 31 January 2019
Bone morphogenetic proteins (BMPs) are key signalling molecules in embryonic development and adult tissue homeostasis, and are heavily regulated in the extracellular matrix.
  Tryptophan catabolites in the regulation of immune cell differentiation and function
  Dr R Williams, Prof T Stone
Application Deadline: 11 January 2019
A major challenge for the treatment of immune-mediated inflammatory diseases is to understand factors which determine the balance between pro- and anti-inflammatory activity of lymphoid and myeloid subsets.
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