G protein-coupled receptors (GPCRs) constitute a very large family of heptahelical, integral membrane proteins that mediate a wide variety of physiological processes ranging from the transmission of light and odorant signals to the mediation of neurotransmission and hormonal actions. Read more
Changes in synaptic strength underlie the formation of neural circuits during development and their modification in learning and memory processes. Read more
Research Group:
The Patrick G Johnston Centre for Cancer Research
STING regulates the innate immune response to viral infection but is also activated in response to DNA damage. This project aims to provide a comprehensive and unbiased analysis of the role of Ub mediated STING regulation in response to DNA damage and its impact on innate immune activation. Read more
Actin is a cytoskeletal protein that plays essential roles in many cellular processes, such as adhesion, intracellular trafficking, membrane dynamics and motility. Read more
Our laboratory is interested in the general question of how mammalian genes are switched on and off during lineage commitment and differentiation. Read more
Our laboratory is interested in the general question of how mammalian genes are switched on and off during lineage commitment and differentiation. Read more
Supervisor. Dr Ivan Kadurin. Funding. SBBS studentship. Deadline. 20th May 2022. The folllowing fully-funded PhD studentship is available in the School of Biological and Behavioural Sciences with an expected start date of Sept 2022. Read more
Neutrophils produce histamine and express two histamine receptors (H2R and H4R). Production of histamine by neutrophils is intriguing and may imply auto-regulation of neutrophil functions. Read more
Embryonic development requires exquisite control of the expression of large numbers of genes, integrating components from the genome, transcriptome and proteome. Read more
A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem. Read more
Notch is a developmental signalling receptor with widespread and important roles in metazoan development and also in adult stem cell regulation. Read more
Development of systems for the generation of red blood cells (RBCs) from stem cell sources (adult peripheral blood, cord blood and induced pluripotent stem… Read more
Notch is one of the major highly conserved signalling pathways that regulate cell-cell communication which involves gene regulation mechanisms that control multiple processes during development and adult life. Read more
A PhD studentship is available to work in the laboratory of Dr. Fiona Wardle (www.kcl.ac.uk/research/profile/wardle-group) in the Randall Centre for Cell and Molecular Biophysics, King’s College London. Read more
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