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We have 42 regulation of gene expression PhD Projects, Programmes & Scholarships
regulation of gene expression PhD Projects, Programmes & Scholarships
We have 42 regulation of gene expression PhD Projects, Programmes & Scholarships
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Understanding regulation of gene expression during development via an integrated computational analysis of ‘omics data
Embryonic development requires exquisite control of the expression of large numbers of genes, integrating components from the genome, transcriptome and proteome. Read more
Epigenetic regulation of microglial gene expression in Alzheimer’s disease
Neuroinflammation is a prominent event Alzheimer’s disease (AD) pathogenesis driven by activation of microglia, the brains resident immune cells. Read more
Partitioning primary and secondary changes of gene expression caused by gene mutations
Control of gene expression is a complex cell process, which involves balancing both the synthesis and the degradation of RNA and protein so as to establish optimal levels of each protein. Read more
Clinical Gastroenterology: The regulation of GDH expression in Clostridioides difficile
Clostridioides difficile infection (CDI), the most common cause of infective antibiotic-associated diarrhea in the western world, is diagnosed by a combination of tests that firstly detect the organism, then the toxins that it produces (Planche 2013). Read more
PhD in Infection, Immunity, Antimicrobial Resistance & Repair - Investigating long noncoding RNAs as novel therapies in chronic kidney disease
SUMMARY. Chronic kidney disease (CKD) affects 15% of the global population and is associated with significant multimorbidity and high mortality, but has no cure. Read more
Epigenetic regulation in heart failure and cardiac sudden death
A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem. Read more
Roles of negative transcriptional regulators in cancer cells
The aim of the project is to investigate how factors involved in mRNA synthesis alter gene expression in human cells. Precise control of transcription and RNA processing is essential for the correct regulation of gene expression in all eukaryotic organisms. Read more
Investigating the epigenetic component of insulin secretion disorders. MRC GW4 BioMed DTP PhD studentship 2024/25 Entry, PhD in Clinical and Biomedical Sciences
About the GW4 BioMed2 Doctoral Training Partnership. The partnership brings together the Universities of Bath, Bristol, Cardiff (lead) and Exeter to develop the next generation of biomedical researchers. Read more
Defining the physiological role and regulation of biological methylations
The regulation of gene expression and function operates at multiple levels. Metabolic pathways in the cell generate metabolites that directly affect DNA, RNA and proteins, regulating the expression and function of many genes, often feeding back on the very enzymes that catalysed their synthesis. Read more
MSc by Research: Regulation of the stability of the Notch intracellular domain in iPS derived presomitic mesoderm cells
Notch is one of the major highly conserved signalling pathways that regulate cell-cell communication which involves gene regulation mechanisms that control multiple processes during development and adult life. Read more
Cell Biology/Genetics: Identifying the mechanisms controlling HPGD expression and the functional consequences of HPGD increase
Prostaglandin E2 (PGE2) is a small lipid molecule frequently elevated during inflammation and cancer through increased synthesis by cyclo-oxygenase 2 (COX-2). Read more
Regulation of gingival mast cells activity by valproic acid-potential to repurpose for treatment of periodontitis?
Background. Periodontitis or chronic inflammation of the tooth-supporting tissues caused by a dysbiotic biofilm is the main cause of tooth loss in the adult population. Read more
GW4 BioMed2 MRC DTP PhD project: A novel link between brain myelination and autism spectrum disorder
This project is one of a number that are in competition for funding from the GW4 BioMed2 MRC Doctoral Training Partnership which is offering up to 20 studentships for entry in September 2024. Read more
Haematology: Oncogenic reprogramming of immune cells; novel mechanism for drug resistance in leukaemia
Under pathogenic challenges, cells of the haematopoietic system become epigenetically reprogrammed and establish immune memory. Read more
Antimicrobial resistance and gene regulation in Enteroaggregative Escherichia coli.
Enteroaggregative Escherichia coli (EAEC) is a major cause of diarrhoeal disease in industrialized and non-industrialized countries and has been shown to be the cause of travellers’ diarrhoea and persistent diarrhoea in children and HIV patients. Read more