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regulation of gene expression PhD Projects, Programs & Scholarships

We have 102 regulation of gene expression PhD Projects, Programs & Scholarships

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  MRC Precision Medicine DTP: Genome-wide, gene-specific patterns of glucocorticoid-receptor co-regulators critical for growth and skeletal development
University of Edinburgh College of Medicine and Veterinary Medicine
  Research Group: The Roslin Institute
  Prof C Farquharson, Prof T Freeman, Prof S Faisal Ahmed, Prof L Savendahl
Application Deadline: 7 January 2019
Background. Glucocorticoids (GCs) are a class of steroid hormones that bind and activate the intra-cellular GC receptor (GR), and regulate transcription of many genes that govern the effects of GCs.
Details
Type/Funding
  Newcastle-Liverpool-Durham Doctoral Training Partnership in Biosciences
Newcastle University
The Newcastle-Liverpool-Durham DTP (http://www.nld-dtp.org.uk/) is a strategic Partnership in Biosciences doctoral training between three research-intensive universities in northern cities of great industrial heritage, Newcastle University, the University of Liverpool and Durham University.
Details
Type/Funding
  Regulation of gene expression in Drosophila ovarian germline stem cells
University of Manchester Faculty of Biology, Medicine and Health
  Prof H Ashe, Prof M Ashe
Applications accepted all year round
Drosophila germline stem cells (GSCs) are a premier model for understanding stem cell regulation. Upon division, one GSC daughter remains a stem cell, whereas the other differentiates into a cystoblast (CB).
Details
Type/Funding
  Development of treatment for Osteoarthritis by blocking metalloproteinases
University of Liverpool Institute of Ageing and Chronic Disease
  Prof G Bou-Gharios
Applications accepted all year round
We aim to understand how MMP13 is transcriptionally regulated and whether a newly identified enhancer is involved in normal and osteoarthritic cartilage.
Details
Type/Funding
  Gene Regulation: How mammalian genes are switched on and off during development and differentiation and how this goes awry in human genetic diseases
University of Oxford Radcliffe Department of Medicine
  Prof D Higgs, Assoc Prof J Hughes, Dr R Gibbons, Dr V Buckle
Application Deadline: 11 January 2019
Other Potential Supervisors. Mira Kassouf. Our laboratory addresses the question of how mammalian genes are switched on and off during development, lineage commitment and differentiation.
Details
Type/Funding
  ChromDesign-ITN: Role of transcription and Polycomb proteins in 3D genome organisation and cell differentiation (subproject ESR11); Hosting institution: Institute of Human Genetics (IGH-CNRS), Montpellier, France
Centre for Genomic Regulation (CRG) Gene Regulation, Stem Cells and Cancer
  Prof G Cavalli, Dr Luciano DiCroce
Application Deadline: 21 December 2018
"ChromDesign” is a European innovative and interdisciplinary Research and Training network, which aims to characterize the impact of the 3D chromatin organization on gene regulation during cellular differentiation and in several human disorders, and to train junior researchers in the biomedical field, either in academia or in the private sector.
Details
Type/Funding
  Chromatin remodelling in health and disease: determining the role of ATRX in the maintenance of chromatin and how mutations perturb disparate nuclear nuclear processes and lead to human disease
University of Oxford Radcliffe Department of Medicine
  Dr R Gibbons, Prof D Higgs
Application Deadline: 11 January 2019
It has become apparent that the regulation of chromatin structure is of paramount importance in a wide variety of fundamental nuclear processes including gene expression, DNA replication, repair and recombination.
Details
Type/Funding
  MRC DiMeN Doctoral Training Partnership: Application of data science to inherited genetic variants of apoptosis genes and susceptibility to breast cancer
University of Sheffield MRC DiMeN Doctoral Training Partnership
  Prof A Cox, Dr A Droop, Dr K Walters
Application Deadline: 21 January 2019
The identification of the breast and ovarian cancer genes BRCA1 and BRCA2 two decades ago has resulted in both improved risk assessment for patients and the use of PARP-inhibitors for treatment.
Details
Type/Funding
  Mathematical modelling of the function of Tristetraprolin, a master regulator of inflammation
University of Birmingham School of Mathematics
  Prof A Clark, Dr S Jabbari
Application Deadline: 6 January 2019
The mRNA destabilising protein tristetraprolin (TTP) is a critical anti-inflammatory protein, which negatively regulates the expression of many inflammatory mediators in many different cell types.
Details
Type/Funding
  MRC DiMeN Doctoral Training Partnership: Antiretroviral-induced metabolic toxicity: Role of adipose- miRNAs as mechanistic regulators and toxicity biomarkers
University of Liverpool MRC DiMeN Doctoral Training Partnership
  Dr S Pushpakom
Application Deadline: 21 January 2019
Supervisors. Dr S Pushpakom. Prof M Bushell. Prof Sir M Pirmohamed. Background. Diabetes, obesity and cardiovascular disease (collectively called cardiometabolic disease) remain a major public health problem worldwide.
Details
Type/Funding
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