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regulation of gene expression PhD Projects, Programs & Scholarships

We have 52 regulation of gene expression PhD Projects, Programs & Scholarships

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  MRC Precision Medicine DTP: Genome-wide, gene-specific patterns of glucocorticoid-receptor co-regulators critical for growth and skeletal development
  Research Group: The Roslin Institute
  Prof C Farquharson, Prof T Freeman, Prof S Faisal Ahmed, Prof L Savendahl
Application Deadline: 8 April 2019
Background. Glucocorticoids (GCs) are a class of steroid hormones that bind and activate the intra-cellular GC receptor (GR), and regulate transcription of many genes that govern the effects of GCs.
  The role of the p53 co-factor JMY in the regulation of gene expression in human cancer
  Dr A Coutts
Application Deadline: 4 April 2019
Tumour growth is achieved by overriding cell cycle control and bypassing cell death mechanisms. Mechanisms influencing cell survival such as apoptosis and autophagy are key determinants of cell fate during stress.
  Regulation of gene expression in Drosophila ovarian germline stem cells
  Prof H Ashe, Prof M Ashe
Applications accepted all year round
Drosophila germline stem cells (GSCs) are a premier model for understanding stem cell regulation. Upon division, one GSC daughter remains a stem cell, whereas the other differentiates into a cystoblast (CB).
  Development of treatment for Osteoarthritis by blocking metalloproteinases
  Prof G Bou-Gharios
Applications accepted all year round
MMP13 (collagenase 3) plays a vital role in the pathogenesis of osteoarthritis (OA) because MMP13 preferentially cleaves type II collagen, the main component of cartilage, and both MMP13 levels and enzymatic activity are enhanced in OA.
  Gene Regulation: How mammalian genes are switched on and off during development and differentiation and how this goes awry in human genetic diseases
  Prof D Higgs, Assoc Prof J Hughes, Dr R Gibbons, Dr V Buckle
Application Deadline: 26 July 2019
Other Potential Supervisors. Mira Kassouf. Our laboratory addresses the question of how mammalian genes are switched on and off during development, lineage commitment and differentiation.
  Chromatin remodelling in health and disease: determining the role of ATRX in the maintenance of chromatin and how mutations perturb disparate nuclear nuclear processes and lead to human disease
  Dr R Gibbons, Prof D Higgs
Application Deadline: 26 July 2019
It has become apparent that the regulation of chromatin structure is of paramount importance in a wide variety of fundamental nuclear processes including gene expression, DNA replication, repair and recombination.
  Molecular mechanisms for the regulation of IL-10 production in T cells
  Dr A O’Garra.
Application Deadline: 18 March 2019
This 4-year PhD studentship is offered in Dr Anne O’Garra’s Group based at the Francis Crick Institute (the Crick). Interleukin (IL)-10 is critical for limiting the immune response to pathogens, therefore preventing immunopathology [1].
  Using CRISPR genome editing to determine the effects of obesity and hypertension associated polymorphisms
  Dr A MacKenzie, Prof M Delibegovic
Application Deadline: 29 March 2019
Introduction. There is now little doubt that morbid conditions such as obesity, cardiovascular disease and diabetes are mechanistically linked.
  Genomics, gene regulation and disease: How human genome variation affects gene expression
  Prof T Milne, Assoc Prof J Hughes, Dr D Waithe
Application Deadline: 26 July 2019
Epigenetics is often described as mechanisms that maintain gene expression profiles through multiple cell divisions long after the initiating signal has been lost.
  Functional and –omics investigation of neutrophil activation in rheumatoid arthritis
  Dr HL Wright, Prof RJ Moots, Dr M Phelan
Applications accepted all year round
Neutrophils are key effector cells in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus and vasculitis.
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