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regulation of gene expression PhD Projects, Programs & Scholarships

We have 70 regulation of gene expression PhD Projects, Programs & Scholarships

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  Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression
  Dr D Blažek, Assoc Prof Z Zdráhal, Dr P Alexiou
Application Deadline: 15 March 2019
CDK11 is ubiquitously expressed in all tissues and the CDK11 null mouse is lethal at an early stage of development indicating an important role for Cdk11 in the adult as well as during development.
  Regulation of gene expression in Drosophila ovarian germline stem cells
  Prof H Ashe, Prof M Ashe
Applications accepted all year round
Drosophila germline stem cells (GSCs) are a premier model for understanding stem cell regulation. Upon division, one GSC daughter remains a stem cell, whereas the other differentiates into a cystoblast (CB).
  Development of treatment for Osteoarthritis by blocking metalloproteinases
  Prof G Bou-Gharios
Applications accepted all year round
MMP13 (collagenase 3) plays a vital role in the pathogenesis of osteoarthritis (OA) because MMP13 preferentially cleaves type II collagen, the main component of cartilage, and both MMP13 levels and enzymatic activity are enhanced in OA.
  Gene Regulation: How mammalian genes are switched on and off during development and differentiation and how this goes awry in human genetic diseases
  Prof D Higgs, Assoc Prof J Hughes, Dr R Gibbons, Dr V Buckle
Application Deadline: 26 July 2019
Other Potential Supervisors. Mira Kassouf. Our laboratory addresses the question of how mammalian genes are switched on and off during development, lineage commitment and differentiation.
  Chromatin remodelling in health and disease: determining the role of ATRX in the maintenance of chromatin and how mutations perturb disparate nuclear nuclear processes and lead to human disease
  Dr R Gibbons, Prof D Higgs
Application Deadline: 26 July 2019
It has become apparent that the regulation of chromatin structure is of paramount importance in a wide variety of fundamental nuclear processes including gene expression, DNA replication, repair and recombination.
  MRC DiMeN Doctoral Training Partnership: Application of data science to inherited genetic variants of apoptosis genes and susceptibility to breast cancer
  Prof A Cox, Dr A Droop, Dr K Walters
Application Deadline: 21 January 2019
The identification of the breast and ovarian cancer genes BRCA1 and BRCA2 two decades ago has resulted in both improved risk assessment for patients and the use of PARP-inhibitors for treatment.
  Promoter regulation heterogeneity and stratification of colorectal cancer organoids
  Prof F Mueller, Dr D J Stekel, Dr A Beggs
Application Deadline: 20 January 2019
Developing tumours are composed of a mixture of clonal subpopulations, containing distinct patterns of mutations leading to distinct transcriptome features.
  MRC DiMeN Doctoral Training Partnership: Antiretroviral-induced metabolic toxicity: Role of adipose- miRNAs as mechanistic regulators and toxicity biomarkers
  Dr S Pushpakom
Application Deadline: 21 January 2019
Supervisors. Dr S Pushpakom. Prof M Bushell. Prof Sir M Pirmohamed. Background. Diabetes, obesity and cardiovascular disease (collectively called cardiometabolic disease) remain a major public health problem worldwide.
  Genomics, gene regulation and disease: How human genome variation affects gene expression
  Prof T Milne, Assoc Prof J Hughes, Dr D Waithe
Application Deadline: 26 July 2019
Epigenetics is often described as mechanisms that maintain gene expression profiles through multiple cell divisions long after the initiating signal has been lost.
  Functional and –omics investigation of neutrophil activation in rheumatoid arthritis
  Dr HL Wright, Prof RJ Moots, Dr M Phelan
Applications accepted all year round
Neutrophils are key effector cells in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus and vasculitis.
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