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regulatory PhD Projects, Programmes & Scholarships
We have 116 regulatory PhD Projects, Programmes & Scholarships
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Understanding the gene regulatory landscape of embryonic stem cells and cancer cells
Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity. Read more
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How to build next-generation regulatory devices for engineering gene expression
Bioscientists are progressively learning how to engineer biological systems like cells and regulatory circuits in ways that give rise to predictable outcomes. Read more
How regulatory immunological cues (re)programme cellular metabolism to control effector T cell behaviour and function
Upon activation a T cell transitions from a state of semi-quiescence to a state of high activity. During the process of activation the T cell therefore needs to up regulate metabolic pathways to acquire the energy and nutrients required to facilitate the behavioural changes associated with its new functional state. Read more
Assessing therapeutic strategies to target the counter-regulatory renin-angiotensin system in cardiovascular disease
Project outline: . The renin angiotensin system (RAS) is a hormonal cascade mediating cardiovascular function. The RAS is key to the development of cardiovascular diseases, including cardiac remodelling in hypertension and heart failure and atherosclerosis. Read more
Control of antibiotic production through synthetic biology of bacterial hormone signalling
There is an urgent need for new antibiotics due to an increase in antibiotic resistance. To produce these essential drugs efficiently in biotechnological systems, we need to have a better understanding of the regulatory mechanisms of antibiotic production. Read more
Combining Synthetic Biology and Modelling to Understand and Predict Evolution
Mutations, and their effects on organismal fitness, lie at the heart of understanding and predicting evolution. Because of its central role in determining evolutionary outcomes, much experimental and theoretical effort has been put into describing the fitness effects of mutations. Read more
Novel anti-pathogen regulatory mechanisms driven by Human Guanylate Binding Proteins
Human GBPs are a family of seven ~65kDa GTPases whose expression is upregulated by IFNg, for example during an infection. All mammalian GBPs contain a GTPase domain and a C-terminal helical region. Read more
Development of a Framework for Regulatory Compliant Adaptive AI Algorithms
Dundalk Institute of Technology. -Regulated Software Research Centre. Project Description. Read more
4-year PhD Studentship: Control of neuronal differentiation and ciliogenesis through mineralocorticoid receptor (MR) – Regulatory Factor X (RFX) interaction in embryonic and adult neurogenesis
Glucocorticoid hormones (GCs) are of critical importance for health[1]. They bind to two receptor types in the hippocampus. the mineralocorticoid (MR) and glucocorticoid receptor (GR) which act as ligand-dependent transcription factors[2-4]. Read more
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Targeted engineering of quantitative traits in plants
Our ability to develop novel beneficial crop traits has significantly improved over the last century, although the ability to maintain this trajectory is limited by allelic diversity. Read more
Laboratory of Gene Regulation
Our laboratory is interested in the general question of how mammalian genes are switched on and off during lineage commitment and differentiation. Read more
Laboratory of Gene Regulation
Our laboratory is interested in the general question of how mammalian genes are switched on and off during lineage commitment and differentiation. Read more
Long noncoding RNA control of Drosophila Hox gene expression
Variation in gene regulation between animals often explains differences between species and individuals, and perturbed gene expression frequently underlies disease states. Read more
The potential utility of human regulatory T cell-deriVed ExtRacellular veSicles to control inflammation in rheUmatoid arthiritiS (VERSUS)
One in every 16 of people in the UK live with an autoimmune condition causing them pain, difficulty, lost opportunities in work and in life, and in many cases placing them at risk of early death. Autoimmunity occurs when the immune system attacks the body. Read more
A PhD Studentship in AI Applications in Future Energy Markets: Market Implications and Regulatory Requirements
Position Summary. Applications are invited for a PhD studentship, to be undertaken at Imperial College London (Electrical and Electronic Engineering Department). Read more