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regulatory PhD Projects, Programmes & Scholarships

We have 116 regulatory PhD Projects, Programmes & Scholarships

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We have 116 regulatory PhD Projects, Programmes & Scholarships

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Understanding the gene regulatory landscape of embryonic stem cells and cancer cells

Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity. Read more

How regulatory immunological cues (re)programme cellular metabolism to control effector T cell behaviour and function

Upon activation a T cell transitions from a state of semi-quiescence to a state of high activity. During the process of activation the T cell therefore needs to up regulate metabolic pathways to acquire the energy and nutrients required to facilitate the behavioural changes associated with its new functional state. Read more

Assessing therapeutic strategies to target the counter-regulatory renin-angiotensin system in cardiovascular disease

Project outline: . The renin angiotensin system (RAS) is a hormonal cascade mediating cardiovascular function. The RAS is key to the development of cardiovascular diseases, including cardiac remodelling in hypertension and heart failure and atherosclerosis. Read more

Control of antibiotic production through synthetic biology of bacterial hormone signalling

There is an urgent need for new antibiotics due to an increase in antibiotic resistance. To produce these essential drugs efficiently in biotechnological systems, we need to have a better understanding of the regulatory mechanisms of antibiotic production. Read more

Combining Synthetic Biology and Modelling to Understand and Predict Evolution

Mutations, and their effects on organismal fitness, lie at the heart of understanding and predicting evolution. Because of its central role in determining evolutionary outcomes, much experimental and theoretical effort has been put into describing the fitness effects of mutations. Read more

Novel anti-pathogen regulatory mechanisms driven by Human Guanylate Binding Proteins

Human GBPs are a family of seven ~65kDa GTPases whose expression is upregulated by IFNg, for example during an infection. All mammalian GBPs contain a GTPase domain and a C-terminal helical region. Read more
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Targeted engineering of quantitative traits in plants

Our ability to develop novel beneficial crop traits has significantly improved over the last century, although the ability to maintain this trajectory is limited by allelic diversity. Read more

Laboratory of Gene Regulation

Our laboratory is interested in the general question of how mammalian genes are switched on and off during lineage commitment and differentiation. Read more

Laboratory of Gene Regulation

Our laboratory is interested in the general question of how mammalian genes are switched on and off during lineage commitment and differentiation. Read more

The potential utility of human regulatory T cell-deriVed ExtRacellular veSicles to control inflammation in rheUmatoid arthiritiS (VERSUS)

One in every 16 of people in the UK live with an autoimmune condition causing them pain, difficulty, lost opportunities in work and in life, and in many cases placing them at risk of early death. Autoimmunity occurs when the immune system attacks the body. Read more

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