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reprogramming PhD Projects, Programs & Scholarships

We have 21 reprogramming PhD Projects, Programs & Scholarships

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  Metabolic reprogramming and chemotherapy resistance in triple-negative breast cancer
Peter MacCallum Cancer Centre Sir Peter MacCallum Department of Oncology, University of Melbourne
  Dr K Brown
Applications accepted all year round
Treatment options for the triple-negative breast cancer (TNBC) subtype of breast cancer are limited to conventional chemotherapy agents.
Details
Type/Funding
  PhD studentship: Investigating whether anti-VEGF treatment can cause the switch to VEGF-independent signalling and metabolic reprogramming in intraocular cells
National Institute for Biological Standards and Control Division of Biotherapeutics
  Dr H Jia
Application Deadline: 11 February 2019
A 3-year full-time PhD studentship is available at the Division of Biotherapeutics, National Institute for Biological Standards and Control (NIBSC), in collaboration with the Division of Medicine, University College London (UCL).
Details
Type/Funding
  Fishing for metabolic clues: Role of the Hippo/Yap pathway in reprogramming metabolism in liver cancer
Peter MacCallum Cancer Centre Sir Peter MacCallum Department of Oncology, University of Melbourne
  Dr A. Cox
Applications accepted all year round
The Hippo/Yap pathway is an evolutionarily conserved cascade that plays a fundamental role in governing organ size control, stem cell homeostasis and cancer.
Details
Type/Funding
  Cutting off the fuel supply to starve cancer: Identifying metabolic vulnerabilities in cancer
Peter MacCallum Cancer Centre Sir Peter MacCallum Department of Oncology, University of Melbourne
  Dr K Brown, Dr A. Cox
Applications accepted all year round
A universal characteristic of all cancer cells is the reprogramming of cell metabolism to provide the energy and building blocks necessary to support proliferation and survival.
Details
Type/Funding
  (A*STAR) Investigating transcriptional networks involved in blood lineage commitment
University of Manchester Faculty of Biology, Medicine and Health
  Prof G Lacaud, Dr K Batta
Application Deadline: 31 January 2019
Transplantation of haematopoietic stem cells (HSCs) is a curative treatment for many malignant and non-malignant haematological disorders.
Details
Type/Funding
  Metabolic Reprogramming in Liver Cancer: delineating the role of reactive oxygen species (ROS) in tumour development
Peter MacCallum Cancer Centre Sir Peter MacCallum Department of Oncology, University of Melbourne
  Prof T. Tiganis
Applications accepted all year round
The Tiganis Laboratory is seeking a highly enthusiastic student to conduct research in cancer metabolism and obesity-associated liver cancer.
Details
Type/Funding
  FOXA1 mutations in Lobular Breast Cancer: Reprogramming Responses to Tamoxifen
University of Nottingham School of Pharmacy
  Prof D Heery, Dr S Johnston
Applications accepted all year round
Tumours of the breast are often hormone-dependent, meaning their growth is driven by steroid hormones such as estrogen. This hormone acts upon the estrogen receptor (ER), which together with other transcription factors such as FOXA1 drives tumour growth.
Details
Type/Funding
  Defining the role of mitochondrial dysfunction in therapy resistance in KRAS mutant colorectal cancer models
Queen’s University Belfast School of Medicine, Dentistry & Biomedical Sciences
  Research Group: Centre for Cancer Research and Cell Biology
  Dr E Kerr, Prof I Mills, Dr M Wilson
Application Deadline: 20 January 2019
Mutant KRAS driven metabolic reprogramming is a key hallmark of cancer, providing the building blocks necessary to support aberrant cancer cell proliferation and is often achieved through rewiring glycolytic, mitochondrial and fatty acid metabolism, reportedly leading to mitochondrial dysfunction.
Details
Type/Funding
  Exploring PARP biology and therapy response via metabolic flux analysis and a novel chemical proteomics workflow
Imperial College London Department of Chemical Engineering
  Dr P DiMaggio, Dr H Keun
Application Deadline: 8 February 2019
Protein ADP-ribosylation is an important yet relatively understudied protein post-translational modification (PTM) that has diverse roles in cellular biology, from DNA damage response to emerging roles in RNA splicing.
Details
Type/Funding
  Metabolic rewiring in liver cancer: Role of oxidative stress and the Nrf2 pathway
Peter MacCallum Cancer Centre Sir Peter MacCallum Department of Oncology, University of Melbourne
  Dr A. Cox
Applications accepted all year round
Many of the major risks factors for developing liver cancer such as alcohol, obesity, smoking and toxin exposure share in common a role for oxidative stress.
Details
Type/Funding
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