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We have 16 reprogramming PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
reprogramming PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 16 reprogramming PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death
All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more
Accelerated tissue regeneration through direct stem cell re-programming
Project ID. SST9. This project hypothesises that the genetic reprogramming of human mesenchymal stromal cells will lead to enhanced tissue regeneration through the increased production of growth factors, potentially aiding the development of personalised cell therapies. Read more
Haematology: Oncogenic reprogramming of immune cells; novel mechanism for drug resistance in leukaemia
Under pathogenic challenges, cells of the haematopoietic system become epigenetically reprogrammed and establish immune memory. Read more
Overcoming Metabolic Reprogramming by Non-Hodgkin Lymphoma to Improve Adoptive Cellular Immunotherapies
About the project. Changes in metabolism are a hallmark of cancer development and have profound inhibitory effects on the local anti-tumour immune response. Read more
Understanding the mechanisms of metabolic reprogramming in cancer: towards novel therapies
In this project, you will examine whether drug-resistant and drug-sensitive cancer cells display distinct metabolic features and aim to do a series of laboratory experiments to investigate the ability of probes, or drugs, to starve cancer cells of glucose. Read more
Haematology: Oncogenic reprogramming of immune cells
Under pathogenic challenges, cells of the innate system become epigenetically reprogrammed and establish immune memory. Read more
Cancer: Inhibiting cell metabolism to enhance tumour cell death
All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more
Developing and applying computational methods to study ageing and rejuvenation
Ageing is the chief biomedical challenge of the 21st century, yet it remains a major puzzle of biology. Recent studies have shown that cells can be rejuvenated, and biological clocks reset, using cellular reprogramming. Read more
Helminth products as macrophage “trainers”: a novel therapeutic tool for the treatment of immune mediated diseases
The innate immune system can display characteristics of immunological memory. This phenomenon, termed “trained immunity”, refers to the long-term functional reprogramming of innate immune cells after the encounter with infectious or non-infectious agents that influences their capacity to respond to a secondary stimulus. Read more
Deuterium metabolic imaging at ultra-high field
Project proposal. Metabolism plays a crucial role in the origin and development of multiple diseases, including neurodegeneration, cardiovascular disease, diabetes, and cancer. Read more
Defining the role of the ketoglutarate dehydrogenase complex (KGDHc) in promoting chemotherapy resistance in glioblastoma
Research Group:
The Patrick G Johnston Centre for Cancer Research
Metabolic reprogramming is a common mechanism by which cancer cells become resistant to chemotherapy. Read more
Assessing the impacts of targeting mRNA translation machinery on metabolic fitness and treatment response of glioblastoma cancer cells
Research Group:
The Patrick G Johnston Centre for Cancer Research
The current standards of care for glioblastoma are rarely curative, highlighting the urgent need for a better understanding of its biology to enhance the development of innovative therapeutic approaches. . Read more
The Survivin Interactome in Health and Disease
Survivin is a small protein that is essential for life but that also contributes to disease, most notably cancer, in which its abnormal overexpression is linked to therapeutic resistance and metastasis. Read more
The role of RNA-binding proteins in determining pancreatic beta-cell fate and diabetes
Endoplasmic reticulum (ER) stress is a significant determinant in the development of type-1 and type-2 diabetes as it has been shown to promote the dysfunction and death of insulin secreting pancreatic beta cells. Read more
MSc by Research: Protein expression and purification from plants to facilitate structural biology in plant-pest interactions
Pests and diseases are a major threat to food security with losses ranging between 20-40%. Aphids are one of the most devastating insect pests, globally. Read more
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