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reprogramming PhD Projects, Programs & Scholarships

We have 19 reprogramming PhD Projects, Programs & Scholarships

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  Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death
  Dr S Papa
Applications accepted all year round

Funding Type

PhD Type

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow.
  Reprogramming the innate immune system to fight ovarian cancer
  Prof M A Vickers, Prof H M Wilson
Application Deadline: 24 June 2020

Funding Type

PhD Type

This project is one of 16 four year PhD Studentships funded by Medical Research Scotland (https://www.medicalresearchscotland.org.uk) to be delivered jointly by the named University and External Partner Organisation (EPO).
  Induced pluripotent stem-cell (iPSC) reprogramming in bone and blood cancers (Ref:SF20/APP/PAL)
  Dr D Pal
Applications accepted all year round

Funding Type

PhD Type

iPSC (somatic cells reprogrammed to an embryonic-stem-cell-like state) are not only a means of patient relevant disease modelling, but de-differentiation of terminal cells to their primitive precursors often reveal aberrations in tissue development.
  Fishing for metabolic clues: Role of the Hippo/Yap pathway in reprogramming metabolism in liver cancer
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

The Hippo/Yap pathway is an evolutionarily conserved cascade that plays a fundamental role in governing organ size control, stem cell homeostasis and cancer.
  Novel mechanisms of hypoxic metabolic reprogramming in metastatic cancers
  Dr L Schito
Application Deadline: 22 June 2020

Funding Type

PhD Type

Hypoxia, a common feature of most human cancers, activates a multifaceted transcriptional, post-transcriptional, translational and epigenetic adaptive program that allows cancer cells to reprogram their metabolism in order to survive the unfavourable conditions of the tumor microenvironment, and subsequently metastasize to secondary sites.
  Metabolic Reprogramming in Liver Cancer: delineating the role of reactive oxygen species (ROS) in tumour development
  Prof T. Tiganis
Applications accepted all year round

Funding Type

PhD Type

The Tiganis Laboratory is seeking a highly enthusiastic student to conduct research in cancer metabolism and obesity-associated liver cancer.
  mRNA translation reprogramming and metabolic re-wiring in response to ribosome-targeted therapies
  Prof R. Pearson, Dr J Kang
Applications accepted all year round

Funding Type

PhD Type

Increased synthesis and activity of ribosomes are associated with oncogenesis downstream of the major oncogenes including MYC, RAS and PI3K.
  Reprogramming of life and death pathways in cancer through unfavourable interactions with healthy cells
  Dr F Spill, Dr D Tennant
Applications accepted all year round

Funding Type

PhD Type

Cells utilise intracellular molecular networks to perform all their essential functions. These functions include the processing of food and generation of energy to live, grow and divide.
  Oncogenic reprogramming of immune cells, a novel mechanism of drug-resistance.
  Dr P Laslo
Applications accepted all year round

Funding Type

PhD Type

Under pathogenic challenges, cells of the innate system become epigenetically reprogrammed and establish immune memory.
  Fueling chemotherapy resistance in triple-negative breast cancer
  Dr K Brown
Applications accepted all year round

Funding Type

PhD Type

Triple-negative breast cancer (TNBC) is a molecularly heterogeneous group of diseases defined by the lack of estrogen receptor (ER), progesterone receptor (PR) and absence of human epidermal growth factor receptor-2 (HER2) amplification.
  PhD at the University of Hong Kong in protein and stem cell engineering
  Dr R Jauch
Applications accepted all year round

Funding Type

PhD Type

My laboratory studies how transcription factors read the genomic code to toggle the switches that turn genes on and off to give cells their identity.
  Dissecting the ageing transcription factor network to set a rational basis for age-intervention strategies
  Dr C Nefzger, Dr M Naval-Sanchez
Application Deadline: 15 June 2020

Funding Type

PhD Type

On a cellular level, ageing appears to be a largely epigenetic phenomenon that can be manipulated by pluripotency induction. Transdifferentiation and iPS technologies are forms of transcription factor (TF)-mediated cell reprogramming.
  Metabolic rewiring in liver cancer: Role of oxidative stress and the Nrf2 pathway
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Many of the major risks factors for developing liver cancer such as alcohol, obesity, smoking and toxin exposure share in common a role for oxidative stress.
  Characterising and editing the age stage of somatic cells
  Dr C Nefzger
Application Deadline: 15 June 2020

Funding Type

PhD Type

On a cellular level, age appears to be a largely epigenetic phenomenon that can be manipulated by pluripotency induction. Transdifferentiation and iPS technologies are forms of transcription factor (TF)-mediated cell reprogramming.
  UCD Ad Astra PhD Studentships

Funding Type

PhD Type

UCD School of Medicine & School of Veterinary Medicine. University College Dublin. Ireland. Funded PhD Project (International students).
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