Programme Director. Professor H McShane. Programme Co-Director. Professor D Clark. The Medical Sciences Division at the University of Oxford offers up to seven fellowships per year for clinical trainees, to allow a 3-year period of study working towards a PhD.
NDORMS 2019/9. Pancreatic cancers are among the most lethal malignancies in human due to highly metastatic characteristics and the poor responsiveness to currently used cancer therapeutics.
NDORMS 2019/13. A major challenge for the treatment of immune-mediated inflammatory diseases is to understand factors which determine the balance between pro- and anti-inflammatory activity of lymphoid and myeloid subsets.
Osteoarthritis (OA) is the most common joint disease in the elderly population, causing significant pain and disability. It is estimated that by by 2020, OA will be the forth leading cause of disability in the world.
Osteoarthritis (OA) is one of the most common chronic diseases affecting the adult population. Currently, definitive diagnosis of OA is usually made using plain x-rays at relatively advanced stages of the disease when there is irreparable damage to the joint(s).
Immune mediated inflammatory diseases (IMIDs) including Rheumatoid arthritis (RA), inflammatory bowel disease and Sjogren’s syndrome result from interactions between innate and adaptive immune cells with stromal fibroblasts driving both inflammation and tissue damage.
The Project. The thymic microenvironment harbours a hierarchical system of lymphoid/T cell progenitors and supports T cell development which is crucial forgeneration of adaptive immune diversity.
A pivotal event promoting adaptive immune responses is binding of antigens to antigen receptors and subsequent actin cytoskeleton reorganisations resulting in receptor microcluster (MC) formation, intracellular signalling, and ultimately immunological synapse (IS) formation.
NDORMS 2019/8. Obesity, insulin resistance, type 2 diabetes (T2D), and associated cardiovascular disease (CVD) often coexist clinically and constitute an epidemic global health problem.
