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rnai PhD Projects, Programs & Scholarships

We have 15 rnai PhD Projects, Programs & Scholarships

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  An in vivo genetic screen of lung function candidate genes using tissue specific RNAi in Drosophila melanogaster
  Dr M Georgiou, Dr I Sayers
Application Deadline: 28 February 2019
Chronic Obstructive Pulmonary Disease (COPD) is a major cause of worldwide mortality and morbidity. Current strategies in management depend on accurate diagnosis, followed by appropriate treatment.
  Physiological and molecular characterisation of altered root hydraulic properties in rice due to allelic variation or genetic manipulation of plasma membrane intrinsic proteins (PIPs, a class of aquaporins)
  Prof A Price
Applications accepted all year round
A cluster of three PIPs on chromosome 7 of rice are all candidate genes for a drought avoidance locus. These genes are highly expressed in roots and thought to have a major role in root hydraulic conductance.
  Identifying new drugs to combat the virulence mechanisms underlying multidrug-resistant typhoid.
  Dr D Humphreys
Application Deadline: 23 January 2019
Multidrug-resistant typhoid. --------------------------------------------. The world is facing an epidemic of multidrug-resistant (MDR) typhoid fever.
  Transcription control and immune evasion in African trypanosomes
  Research Group: Division of Cell & Molecular Biology
  Prof G Rudenko
Applications accepted all year round
Trypanosomes are unicellular eukaryotes which cause African Sleeping Sickness, which is endemic to subSaharan Africa. Trypanosomes can be easily grown as suspension cell lines in the laboratory, where they are straightforward to manipulate and genetically modify.
  FGFR signalling in breast cancer
  Dr A Chioni
Applications accepted all year round
Growth factors are used during development to convey messages that tell cells to divide, survive, migrate and adopt a particular fate.
  MRC DiMeN Doctoral Training Partnership: Elucidating new redox-signalling mechanisms that act to maintain healthy tissues during ageing
  Prof E Veal, Prof M Jackson, Dr N Conlon
Application Deadline: 21 January 2019
Project Summary. This iCASE MRC studentship provides an exciting opportunity to use a diverse range of cutting-edge techniques, and exploit the advantages of different model systems, to identify new molecular mechanisms, that protect against ageing/age-associated diseases.
  Investigating the Drosophila DF31 protein to gain insight into the mechanisms and chromatin maintenance in animal cells
  Dr S Cotterill, Dr A Nohturfft
Applications accepted all year round
The Drosophila DF31 protein is an abundant ribonucleoprotein that localises to euchromatic regions and is involved in maintaining chromosome structure.
  Investigating the role of lysine methylation in the DNA damage response.
  Dr M Higgs
Applications accepted all year round
Our genomic DNA is under constant attack from DNA damaging agents, which are a continuing threat to genomic integrity. Defective resolution of DNA damage underlies several human diseases, including haematopoietic abnormalities and developmental disorders as well as cancer.
  Investigating how platelet-derived ncRNAs are altering the genetics of breast cancer cells
  Research Group: Institute of Cancer Therapeutics
  Dr J Boyne, Prof P Loadman
Applications accepted all year round
Platelet-derived microparticles (PMPs) are capable of delivering non-coding RNAs (ncRNAs) to cells that modulate gene expression.
  Using state-of-the-art proteomics to study the cellular and extracellular protein composition in human kidney disease; identification of novel biomarkers and bioactive drug targets in IgA Nephropathy
  Dr A Didangelos, Prof J Barratt
Applications accepted all year round
One of the key pathological characteristics of IgA nephropathy (IgAN) is the maladaptive and chronic accumulation and remodelling of the extracellular matrix (ECM) in affected glomeruli leading to fibrosis and progressive loss of function.
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