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rnai PhD Projects, Programmes & Scholarships
We have 15 rnai PhD Projects, Programmes & Scholarships
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MScR - In vivo characterisation of novel risk genes for Alzheimers disease identified by Genome Wide Association Studies
Genome Wide Association Studies (GWAS) for Alzheimer’s disease (AD) have identified a number of genes that are significantly associated with the disease (van der Kant et al., 2019). Read more
Evolutionary ‘frenemies’? Understanding the molecular mechanisms underpinning the evolution of endosymbiosis
Symbioses are abundant, taxonomically widespread, ecologically important in a wide-range of habitats, economically important in agricultural systems, and consequently underpin the biodiversity and function of both natural and artificial ecosystems. Read more
MSc by Research: Genetic interactions and novel genes that regulate lignin biosynthesis and straw quality in barley
Lignin is a major component of plant cell walls, and has a significant influence on the digestibility and uses of plant biomass. The lignin biosynthesis pathway has been one of the most intensively studied. Read more
Deciphering a novel anti-ageing epigenetic programme
Over two decades of intense research in the field of epigenetics have produced compelling evidence that chromatin modifications are crucial for processes such as DNA repair, transcription, splicing, mitosis, meiosis, and in the preservation of the epigenetic memory of cells. Read more
Understanding regulation of gene expression during development via an integrated computational analysis of ‘omics data
Embryonic development requires exquisite control of the expression of large numbers of genes, integrating components from the genome, transcriptome and proteome. Read more
Innate Instruction of Adaptive Immunity
Talented and motivated students, passionate about doing research, are invited to apply for this PhD position. The successful applicant will join the Crick PhD Programme in September 2024 and will register for their PhD at one of the Crick partner universities (Imperial College London, King’s College London or UCL). Read more
Funded PhD - Modelling the role of L-type voltage-gated calcium channels (CACNA1C) signalling in epilepsy and mental health
The student will receive high quality multi-disciplinary cross-GW4 training in modelling CACNA1C signalling in epilepsy, Timothy Syndrome (TS), bipolar disorder and schizophrenia. Read more
Molecular characterisation of scavenger receptor ligand binding.
Scavenger receptors have been identified as being important in Human disease and normal physiological responses. Scavenger receptors are a large family of cell surface receptors that are expressed ubiquitously. Read more
The regulation of scavenger receptors in cancer
The expression of some scavenger receptors has been identified as being poor for cancer prognosis. Scavenger receptors are a large family of cell surface receptors that are expressed ubiquitously in the Human body. Read more
White Rose BBSRC DTP: The genetic and developmental control of complex nanostructure formation in butterfly wing scales
Butterfly wings are natural wonders, covered in colourful scales that are used for signaling, thermoregulation and to help with aerodynamic performance. Read more
GW4 BioMed2 MRC DTP PhD project: Developing new weapons to fight drug-resistant superbugs – targeting lipoteichoic acid biosynthesis
This project is one of a number that are in competition for funding from the GW4 BioMed2 MRC Doctoral Training Partnership which is offering up to 20 studentships for entry in September 2024. Read more
Dissecting mechanism of drug responses to novel anti-cancer therapies
Repurposing drug screens with compounds that have already gained FDA approval can accelerate the identification of new therapies to treat an illness and in the cancer setting extend life or provide compassionate care. Read more
Basal stem cells in the lung and their recognition of dying cells
Stem cell division and differentiation is critical for barrier repair following inflammation, but the initial trigger for this process is unknown. Read more
Ion channel signalling in cancer cells
Our cells constantly sense and transport ions present in their environment. From embryonic development to epilepsy to heart disease to cancer, our cells’ ability to respond to changes in the ionic microenvironment is essential for healthy ageing. Read more
Uncovering novel molecular targets for cancer chemoprevention in oral squamous cell carcinoma
Background. Oral epithelial dysplasia (OED) is a potentially malignant condition with a 15% transition rate into oral squamous cell carcinoma (OSCC) (1). Read more
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