Professor Lars Fugger leads a neuroinflammatory research group (www.ocni.co.uk), with the primary research focus being to understand the genetic and environmental risk factors that cause multiple sclerosis.
Multiple sclerosis (MS) is a chronic inflammatory disease involving immune attack by autoreactive T cells and B cells. We have been studying the phenotype, frequency and antigen specificity of these adaptive immune cells in human MS.
This project’s specific objective is to study the molecular role(s) that the RNA helicase UPF1 plays in RNA processing. UPF1 is a key player in nonsense-mediated mRNA decay (NMD), it is universally conserved in eukaryotes and is essential to the development of many organisms .
Amyotrophic Lateral Sclerosis (ALS) is caused by the breakdown of upper and lower motor neurons leading to the progressive weakness and atrophy of muscle, often resulting in respiratory failure and death within a few years of diagnosis.