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sclerosis PhD Projects, Programmes & Scholarships

We have 22 sclerosis PhD Projects, Programmes & Scholarships

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We have 22 sclerosis PhD Projects, Programmes & Scholarships

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A Cell Interactome Approach to Model, Characterise and understand Novel Mechanisms of Disease in Progressive Multiple Sclerosis

(co-supervised with A Nicaise and I Mohorianou). Recent work suggests that cellular ageing, known as senescence, of endogenous stem-like cells in the brain may contribute to the chronic inflammation and neurodegeneration seen in people with progressive multiple sclerosis (PMS). Read more

Brain Repair in Adults and Children with Multiple Sclerosis

(co-supervised by Dr Nick Cunniffe). We are interested in the process of remyelination in humans, especially in assessing how the rate of remyelination changes with age and how best to test drugs that potentially promote remyelination. Read more
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Using multi-omics to discover prognostic biomarkers for Multiple Sclerosis onset and progression

About the research project. Multiple sclerosis (MS) is a devastating autoimmune neurodegenerative disease of the central nervous system, caused by an interplay between environmental and genetic factors. Read more

Self funded BMS Project: Innate immune responses in aymotrophic lateral sclerosis and frontotemporal dementia.

Applications accepted for PhD Only. Neurons express an innate immune response cascade to regulate synaptic homeostasis. We have identified activation of components of this innate immune cascade in response to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia associated (FTD) mutations. Read more

Ambulatory monitoring of Raynaud’s phenomenon and systemic sclerosis associated microcirculation

Systemic sclerosis (SSc), a microvascular autoimmune disease, causes damage to the small blood vessels (microvasculature). Although rare it has the highest mortality of all rheumatological conditions and causes significant morbidity. Read more

Identifying immune mechanisms in the CNS as targets for the treatment of paediatric Multiple Sclerosis (MS)

Paediatric MS accounts for 2.7-10.5% of the total MS population and can affect children of all ages. Paediatric MS is not curable and as such, is a lifelong debilitating disease that restricts the life quality of affected children for their entire life. Read more

Can we repair brain damage using the immune system?

Successful long-term tissue regeneration of any human organ beyond the experimental state remains elusive. Given that the immune system plays a key role in tissue regeneration, including in the CNS, one of the most promising novel approaches is to integrate endogenous immune mechanisms into regenerative strategies. Read more

How do antimicrobial peptides alter T cell cytokine production?

Antimicrobial peptides are released by neutrophils, mast cells and epithelial cells during infectious and inflammatory disease. They have many effects on innate and adaptive immune cells. Read more

Axon Degeneration Mechanisms in Human Disease

Research in our laboratory showed that a preventable mechanism of axon degeneration, known as programmed axon death or Wallerian degeneration, is shared by injury and disease, and is regulated by NAD and related metabolites. Read more

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