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  MRC DTP 4 Year PhD Programme: InSilico Fragment Screening in Drug Discovery
  Dr I H Gilbert, Prof P Wyatt, Dr F Zuccotto
Application Deadline: 19 May 2019
The process to develop new medicines stars with the identification of small molecules that can modulate a biological target or pathway associated to the disease.
  Crime scene based screening and identification of intimate body fluids
  Dr G Williams
Applications accepted all year round
The screening and identification of blood at crime scenes has been extensively and exhaustively researched with a range of strategies developed ranging from general LMG/KM testing through to ALS, Raman and Hyperspectral imaging.
  Rapid additive and solvent screening for morphology control in continuous crystallisation via machine learning
  Dr B Castro Dominguez, Prof C C Wilson
Application Deadline: 24 March 2019
The Centre for Sustainable Chemical Technologies (CSCT) at the University of Bath focuses on developing new molecules, materials, processes and systems from the lab right through to industrial application, with an emphasis on practical sustainability.
  Development of drug screening platforms for central nervous system regeneration
  Research Group: MRC Centre for Reproductive Health
  Dr V Miron
Application Deadline: 28 March 2019
Numerous neurological disorders are characterized by damage to the insulation surrounding nerve fibres, termed myelin, leading to nerve damage/ loss and cognitive, motor, and sensory deficits.
  Novel assays for screening drug – lipid membrane interactions
  Dr G Shearman, Prof R Singer
Applications accepted all year round
Small molecule therapeutics represent a major contributor to human health and wellbeing both in developed and developing economies.
  DTC MATH 12 - Mathematical analysis of Thomas-Fermi theory of charge screening in graphene
  Dr V Moroz
Applications accepted all year round
Mathematically, graphene could be considered as a two-dimensional object. Two dimensionality of graphene leads to a number of remarkable physical and mechanical properties which also give rise to new challenging mathematical problems.
  Understanding Sperm Function required for Fertilisation Using Phenotypic Screening
  Dr S Martins da Silva, Prof C Barratt
Application Deadline: 1 May 2019
Infertility is a global health problem, estimated to affect 1 in 7 couples (Barratt et al., 2017). It has significant impacts on those affected, and its treatment places substantial financial strain both on infertile couples and health services.
  Identification, screening and scale up of enzymes in the Biocatalyst Discovery Metagenomics platform
  Prof N Scrutton, Prof N Turner
Applications accepted all year round
Background – Enzyme engineering strategies, supported by computational and molecular modelling to maximise speed and efficiency, has been shown to be a powerful tool for (semi-) rational design of enzymes.1,2 We will evaluate protein mobility/dynamics, docking/binding of substrates and calculation of free energy barriers for catalysis.
  Genome and transcriptome sequencing and functional analysis to find new mutation types in patients with inherited blindness
  Prof C Inglehearn
Applications accepted all year round
Human inherited retinal dystrophies (IRDs) result from mutations in over 200 different genes, many of them first implicated by the Leeds Vision Research Group (eg Panagiotou E et al 2017, AJHG 100:960-968; El-Asrag M et al 2015, 96:948-54).
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