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We have 27 senescence PhD Projects, Programmes & Scholarships

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senescence PhD Projects, Programmes & Scholarships

We have 27 senescence PhD Projects, Programmes & Scholarships

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Ameliorating ageing, age-related diseases and cancer by targeting senescence and the p53 pathway

University of Leicester Molecular and Cell Biology
Ageing is a process defined by the accumulation of old (senescent) cells in tissues. It has been shown that senescent cells interfere with the normal functions of most organs and thus lead to the phenotypic changes associated with ageing, as well as the establishment of age-related diseases. Read more
 Supervisors: Prof S Macip, Prof S Cowley
 4 January 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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MRC DiMeN Doctoral Training Partnership: Targeting Salmonella subversion of cellular senescence to combat antimicrobial-resistant typhoid fever

University of Sheffield MRC DiMeN Doctoral Training Partnership
Antimicrobial-resistant typhoid fever. The world faces epidemics of antimicrobial-resistant (AMR) typhoid fever caused by Salmonella Typhi that underlies 12 million cases / 129 000 deaths each year. Read more
 Supervisors: Dr D Humphreys, Dr MA Gordon, Dr J Meiring
 17 December 2023  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Nuclear and transcriptional dysregulations during cellular senescence

University of Leicester Molecular and Cell Biology
Cellular senescence, which is characterised by a proliferation arrest, is a driver of ageing (1). Several stresses can induce cellular senescence, including persistent DNA damage, telomere dysfunction, and oncogene activation. Read more
 Supervisors: Dr MT Tellier, Dr Y Markaki
 4 January 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Boots CTP: Elucidating epigenetic programs governing stress induced senescence (SISP) in melanocytes across ethnic groups

University of Bradford Faculty of Life Sciences
  Research Group: Chemistry and Biosciences
Skin ageing is induced by intrinsic (replicative stress due to ageing) and extrinsic pathways e.g., exposure to environmental insults including UV radiation and oxidative stress1. Read more
 Supervisors: Dr K Swaminathan, Dr D Ansell, Prof M J Thornton
 9 January 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Cellular senescence: investigating a novel hijack target of the typhoid pathogen Salmonella Typhi

University of Sheffield School of Biosciences
Background and Timeliness. The world faces epidemics of antimicrobial-resistant (AMR) typhoid fever caused by Salmonella Typhi that underlies 12 million cases / 129 000 deaths each year. Read more
 Supervisor: Dr D Humphreys
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Role of cellular senescence in progression of chronic kidney disease

Ulster University - Magee Campus Faculty of Health and Life Sciences
Senescence is a process where cells cease dividing and undergo distinctive phenotypic changes. Read more
 Supervisors: Dr T Rai, Dr S Watterson, Dr F McCaroll
 5 February 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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BBSRC NLD Doctoral Training Partnership: Critical evaluation of mitophagy, mitochondrial dysfunction and senescence axis

Newcastle University Faculty of Medical Sciences
Many types of cells become senescent as a response to a variety of stressors, and show distinct senescence phenotype such as persistent DNA damage, mitochondrial dysfunction, increased levels of reactive oxygen species (ROS) and pro-inflammatory cytokine. Read more
 Supervisors: Dr S Miwa, Dr V Korolchuk, Prof A McArdle
 15 January 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Targeting senescence to ameliorate ageing and treat cancer and other age-related diseases

University of Leicester Molecular and Cell Biology
Ageing is a biological process that affects all humans. Despite the scientific advances of the past decades, the mechanisms that lead to ageing are not fully understood. Read more
 Supervisor: Prof S Macip
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MSc By Research: Profiling of extracellular vesicles derived from Alzheimer’s Disease and control brains

Aberdeen University School of Medicine, Medical Sciences & Nutrition
The MSc by Research programme at the University of Aberdeen is for students interested in a research-intensive master's degree. It is designed specifically to enhance your skills for a PhD or research career. Read more
 Supervisors: Prof B Platt, Dr A Sil
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Evaluating the impact of genotoxic aldehyde stress in premature ageing

University of Leicester Department of Chemistry
Aldehydes are highly reactive chemicals that are common pollutants and human metabolites. However, the vast majority of aldehydes’ biological functions are unknown. . Read more
 Supervisors: Dr R Hopkinson, Dr K Tanaka
 4 January 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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The Environmental Drivers of DNA methylation and Senescence: An Experimental Test in Wild Mice

University of Edinburgh School of Biological Sciences
  Research Group: Institute of Ecology & Evolution
Summary. Why do we senesce? Lifestyle appears to accelerate the ageing process in humans, but we know much less about the stressors that cause age-related declines in wild animals. Read more
 Supervisors: Prof T Little, Dr A Pedersen
 17 January 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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NERC E4 The Environmental Drivers of DNA methylation and Senescence: An Experimental Test in Wild Mice

University of Edinburgh School of Biological Sciences
  Research Group: Institute of Ecology & Evolution
Summary. Why do we senesce? Lifestyle appears to accelerate the ageing process in humans, but we know much less about the stressors that cause age-related declines in wild animals. Read more
 Supervisors: Prof T Little, Dr A Pedersen
 4 January 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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The Genetic, Epigenetic and Environmental Drivers of Senescence: An Experimental Test in Wild Mice

University of Edinburgh School of Biological Sciences
  Research Group: Institute of Ecology & Evolution
Age predicts many things about health, including infections we might have, our risk of dying from infections, or which chronic diseases we are at risk from. Read more
 Supervisors: Prof T Little, Dr A Pedersen
 17 January 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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(BBSRC DTP) How does ageing affect protein homeostasis and structure?

The University of Manchester Faculty of Biology, Medicine and Health
The World Health Organisation estimates that by 2050, there will be two billion people aged 60 and above. Despite this remarkable progress in extending human life, health issues specific to the ageing body can severely limit the quality of life and well-being of the elderly. Read more
 Supervisors: Dr J Swift, Prof S Hubbard, Dr A Politis
 19 January 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Stress response and resilience for longevity: sex and mitochondria

Newcastle University MRC DiMeN Doctoral Training Partnership
Background. Centenarians and supercentenarians (110 years+) show a remarkable resilience – an ability to ‘bounce back’ after a significant stress event, such as a fall, infection or surgery. Read more
 Supervisors: Dr S Miwa, Dr J Stewart, Dr D Shanley, Dr C Chen
 17 December 2023  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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