microRNAs as tools to regulate senescence of musculoskeletal cells during ageing
Dr K Whysall, Prof P Clegg
22 November 2019
As the ageing population continues to increase, it is important to address ageing-related health issues. There is currently no effective treatments for many common musculoskeletal (MSK) disorders, such as sarcopenia or osteoarthritis, which increase in prevalence during ageing.
Ameliorating ageing and age-related diseases by targeting senescent cells
Dr S Macip, Dr S Cowley
1 January 2019
Ageing is a process defined by the accumulation of old (senescent) cells in tissues. It has been shown that senescent cells interfere with the normal functions of organs and thus lead to the normal phenotypic changes associated with ageing as well as the establishment of age-related diseases.
Nuclear pores, heterochromatin organisation and cellular senescence
MRC Human Genetics Unit
Prof W Bickmore
18 January 2019
This is one of several projects available on an MRC funded 4-year multi-disciplinary PhD programme in Human Genetics, Genomics and Disease at the MRC Human Genetics Unit (HGU), part of the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh.
Evolution of asynchronous senescence in natural populations
Institute of Evolutionary Biology
Dr J Moorad, Prof D Nussey
13 December 2018
Senescence, or ageing, appears to be universal across nearly all known forms of life. Whilst it is most dramatically manifested as an increase in mortality risk with advancing age, it is also exhibited in many and diverse traits affecting reproduction, behaviour, and physiology.