microRNAs as tools to regulate senescence of musculoskeletal cells during ageing
Dr K Whysall, Prof P Clegg
22 November 2019
As the ageing population continues to increase, it is important to address ageing-related health issues. There is currently no effective treatments for many common musculoskeletal (MSK) disorders, such as sarcopenia or osteoarthritis, which increase in prevalence during ageing.
Nuclear pores, heterochromatin organisation and cellular senescence
MRC Human Genetics Unit
Prof W Bickmore
18 January 2019
This is one of several projects available on an MRC funded 4-year multi-disciplinary PhD programme in Human Genetics, Genomics and Disease at the MRC Human Genetics Unit (HGU), part of the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh.
Investigating the effect of telomere length on endothelial cell function
Dr V Codd, Prof NJ Samani
27 January 2019
Telomeres are protein bound DNA repeat structures at the ends of eukaryotic chromosomes, Telomere length (TL) has been proposed as a marker of biological ageing and shorter TL associates with several age related diseases, including coronary artery disease (CAD).