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We have 137 sequencing PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
sequencing PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 137 sequencing PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Utilising Long Read Sequencing Technology for Improved Cancer Diagnosis
Genetic diagnostics currently forms a key part of the care pathway for cancer patients, with results being used to plan patient care and treatment. Read more
Structural and copy number variation analysis using adaptive long read sequencing
Long Read Sequencing (LRS) is a critical tool for understanding disease and variation in populations of samples ranging from human to critical food crops. Read more
Evaluation of RNA Epigenetic modifications as non-invasive biomarkers for human diseases
The proposed project is within the broad area of biomedical genomics for healthy ageing. Globally, the major focus is to identify biomarkers for human diseases, that can help early diagnosis and prognosis of the disease towards a better management and a better quality of life for an ageing population. Read more
Examining the legal, ethical and social implications of whole genome sequencing at birth
Developments in genomic testing mean that it is now possible to conduct whole genome sequencing of newborn infants. Read more
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Pathogen surveillance from wastewater using real-time nanopore sequencing
Genomic surveillance from wastewater was used successfully during the SARS-CoV-2 pandemic to inform public health measures by monitoring case numbers and the emergence of new variants. Read more
The SPICeD project - Spatial transcriptomics to understand Parenchymal-Immune interactions in Coeliac Disease
Theme Overview. The SPICeD project (Spatial transcriptomics to understand Parenchymal-Immune interactions in CoeliacDisease) is a DPhil project to discover and understand cell-cell interactions in the intestinal mucosa in coeliac disease, and their significance in the disease pathology. Read more
Novel AI methods for zoonotic disease prevention and prediction - Host association studies of Salmonella Typhimurium using Machine Learning
In this PhD project you will join a Government-Academia collaborative project to develop novel computational approaches to detect and predict a type of infectious diseases termed zoonotic disease that can be transmitted between species, from animals to humans (and vice-versa). . Read more
Genome to phenome: exploiting multi-omics and deep learning strategies to decipher the importance of isoforms in animal health and behaviour. Epigenetics. Transcriptomics. Proteogenomics. Bioinformatics.
Overview. The molecular process that leads to multiple mRNA transcripts being produced from the same segment of DNA (aka gene) is known as alternative splicing (AS). Read more
Understanding asthma through population-scale long-read sequencing of diverse genomes
Understanding the diversity of human genomes is important for understanding the contribution of genetic variation to disease, including asthma. Read more
Understanding disease through population-scale long-read sequencing of diverse genomes
Understanding the diversity of human genomes is important for understanding the contribution of genetic variation to disease. Read more
Investigating the communication between cancer cells and cells in the tumour microenvironment to improve our understanding of epigenetic regulatory mechanisms and identify new targets for cancer therapy
It is well-established that the molecular mechanisms controlling gene expression are disrupted in cancer cells and work in this area has laid the foundations for targeted cancer therapies. We are interested in the regulatory pathways that control cell proliferation and cell migration and the events that disrupt this control in multiple types of cancer. Read more
SCENARIO - Understanding freshwater ecosystem health from a microbial perspective (SC2023_38)
This project is based at the UK Centre for Ecology and Hydrology, Wallingford. Freshwater environments are exposed to a variety of stressors that contribute to the decline of freshwater species, ecosystems, and the services they provide. Read more
Tissue-specific roles of human endogenous retroviruses in urothelial carcinoma
Human endogenous retroviruses (HERVs) are the remnants of retroviral infections in our evolutionary past that contribute 8% of our genome. Read more
Genetics: Investigating the molecular basis of optic nerve degeneration in glaucoma to try and develop a personalized medicine strategy for treatment
The optic nerve is a special sensory nerve that transmits visual impulses from the retina to the brain. Primary Open Angle Glaucoma (POAG) is a chronic, progressive optic neuropathy of multifactorial origin that affects 1 in 10 elderly individuals. Read more
Genetics: Genetic studies of developmental eye disorders to investigate genotype-phenotype correlations
Developmental eye defects that affect the front of the eye give rise to a spectrum of congenital ocular phenotypes that affect the cornea, lens, iris, trabecular meshwork or the globe itself. Read more