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  Barcoding atherosclerotic plaque cells: single cell sequencing to reveal heterogeneity and functional impact of atherosclerotic plaque cells
  Dr J Sluimer
Application Deadline: 16 July 2020

Funding Type

PhD Type

A position for a PhD-student (gross €2325—€2972 per month) is available in dr. Sluimer’s team in the experimental vascular Pathology Dept.
  Genome and transcriptome sequencing and functional analysis to find new mutation types in patients with inherited blindness
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Human inherited retinal dystrophies (IRDs) result from mutations in over 200 different genes, many of them first implicated by the Leeds Vision Research Group (eg Panagiotou E et al 2017, AJHG 100:960-968; El-Asrag M et al 2015, 96:948-54).
  Using massively-paralleled sequencing to find the cause of inherited conditions that affect the front of the eye
  Dr M Ali, Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Eye diseases are a common cause of human disability and many of them are inherited. These include congenital as well as adult-onset conditions and diseases of ageing, and may involve abnormalities at the back of the eye or the anterior eye structures.
  Whole genome sequencing to investigate the mechanisms of fluoroquinolone-resistance in field isolates of Salmonella spp.: a nationwide study of recreational areas
  Research Group: Biomedical Research Group
  Dr C Walker, Dr C O'Kane, Dr H McRobie, Dr J Sullivan
Applications accepted all year round

Funding Type

PhD Type

Research Group. Biomedical Research Group. https://www.anglia.ac.uk/science-and-engineering/research/institutes-and-groups/biomedical.
  Using next-generation sequencing and CRISPR-Cas9 gene editing to investigate penetrance and phenotypic variation in inherited eye disease
  Dr C Toomes
Applications accepted all year round

Funding Type

PhD Type

Human inherited retinal diseases (IRDs) result from mutations in over 250 different genes, many of them implicated by the Leeds Vision Research Group (eg Panagiotou et al 2017, AJHG 100:960-968; El-Asrag et al 2015, 96:948-54).
  Identifying pharmacological targets for osteoporosis intervention using whole-genome and exome sequencing of bone related phenotypes
  Dr J Kemp
Applications accepted all year round

Funding Type

PhD Type

Osteoporosis (OP) is an often asymptomatic multi-factorial condition that is characterized by a progressive loss of bone mass resulting in increased fracture (FX) risk and reduced lifespan(1).
  Analytic methods for detecting and making sense of somatic genomic rearrangements
  Prof A Papenfuss
Applications accepted all year round

Funding Type

PhD Type

Bioinformatics is the application of mathematics, statistics and computational methods to the analysis of molecular biology data.
  Precision Medicine DTP: Time-resolved single-cell analysis of neural cell differentiation in motor neuron disease (MND)
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr C Sibley, Dr R Grima
Application Deadline: 1 June 2020

Funding Type

PhD Type

Industrial Partner. Dolomite Bio. Background. Motor neuron disease (MND) is a relentlessly progressing and devastating condition caused by the selective degeneration of upper and lower motor neurons essential for all movement.
  Genetic studies of corneal endothelial dystrophies and development of alternative treatment options
  Dr M Ali
Applications accepted all year round

Funding Type

PhD Type

The cornea is the protective front part of the eye that provides most of the eyes focusing power. The endothelium is a single-cell layer on the inside of the cornea that maintains fluid balance and is required for corneal transparency.
  Novel non-coding RNAs in Drug response, DNA Damage and Aging
  Dr A Kanhere
Applications accepted all year round

Funding Type

PhD Type

Background. One of the biggest surprises of human genomic sequencing was the finding that only ~2% of the genome codes for proteins.
  Investigating the communication between cancer cells and cells in the tumour microenvironment to improve our understanding of epigenetic regulatory mechanisms and identify new targets for cancer therapy
  Prof K Gaston, Dr P-S Jayaraman
Applications accepted all year round

Funding Type

PhD Type

It is well-established that the molecular mechanisms controlling gene expression are disrupted in cancer cells and work in this area has laid the foundations for targeted cancer therapies.
  PhD Scholarship in Novel Machine Learning Methods for DNA Sequencing
  Dr T Heinis
Application Deadline: 31 August 2020

Funding Type

PhD Type

The Department of Computing is a leading department of Computer Science among UK Universities, and has consistently been awarded the highest research rating from the Higher Education Funding Council.
  Transforming data to understanding and knowledge for the sequencing of therapeutic oligonucleotides by mass spectrometry
  Prof G Langley
Application Deadline: 1 July 2020

Funding Type

PhD Type

Supervisor. Prof. G J Langley, Dr E Stulz, Dr A Ray (AstraZeneca), Dr S Holman (AstraZeneca). Project description. Oligonucleotides are a promising and growing class of therapeutics.
  Investigation of a probiotic strain of Lactobacillus plantarum 2025 and the development of novel antibacterials
  Prof A Karlyshev
Applications accepted all year round

Funding Type

PhD Type

Background. The rise of multidrug resistant forms of microbial pathogens imposes a serious problem to public health worldwide. The rapid spread of antimicrobial resistance is associated with misuse of conventional antibiotics.
  Clinical cancer bioinformatics: developing new bioinformatics methods for improved analysis of cancer gene hybridisation capture panels
  Prof A Papenfuss
Applications accepted all year round

Funding Type

PhD Type

Bioinformatics is the application of mathematics, statistics and computational methods to the analysis of molecular biology data.
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