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signalling PhD Projects, Programmes & Scholarships

We have 232 signalling PhD Projects, Programmes & Scholarships

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We have 232 signalling PhD Projects, Programmes & Scholarships

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Biological role of neuropeptides and their receptors

Cell signalling is critical to the co-ordination and functioning of all cells. Cell signalling allows cells to co-ordinate activities within the intracellular environment as well as ensuring cells know how to correctly respond to other cells and to an ever-changing extracellular environment as well. Read more

Obtaining an integrated understanding of oncogenic RAS signalling

The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. The physiological importance of RAS signalling is evident as about 25% of all human cancers harbour mutations in ras genes, where kras is most frequently mutated (about 18%) (COSMIC, v94). Read more

Omics approaches to reveal novel players regulating cell signalling in breast cancer

There is an unmet need for novel molecular targeted therapies to improve breast cancer patient survival outcomes. Available therapies for breast cancer patients are based on surgery, radiation, or targeted therapies mostly directed against signalling players, like kinases. Read more

Determining the roles that GRK and arrestin proteins play in the development of hypertension and vascular disease

G protein-coupled receptors (GPCRs) constitute a very large family of heptahelical, integral membrane proteins that mediate a wide variety of physiological processes ranging from the transmission of light and odorant signals to the mediation of neurotransmission and hormonal actions. Read more

FGF signalling in regulation of tumour immune microenvironment

Immune “cold” tumours are tumours with little infiltrations of T lymphocytes and therefore immune suppressed, developed by a mechanism of evasion from immune surveillance through cancer progression (Hallmarks of Cancer). Read more

Deciphering the role of the intracellular domains of P2X7 in coupling to downstream signalling

P2X7 receptors are ion channels that are found on the surface of immune cells, where they respond to the binding of extracellular ATP, a damage signal released by dying cells in infection and injury. Read more

Prostate cancer signalling to the bone micro-environment - from molecular characterization to potential novel therapies.

About the Project. Prostate cancer is responsible for over 52,000 cancer diagnoses within the UK per annum, and is the most common cancer in males, accounting for 27% of all new cancer cases diagnosed within men in 2016-2017. Read more

Systems level analysis of platelet signalling

We are interested in how intracellular signal transduction networks bring about complex biological behaviours in cells. We do this by combining computational biology with wet laboratory experimentation. Read more

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