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We have 126 single cell PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
single cell PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 126 single cell PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Using single cell transcriptomic and blood proteomic data to understand how pancreatic cancer causes diabetes and to find ways to detect the cancer earlier.
Background. Pancreatic cancer is the deadliest of the common cancers. Five-year survival remains low at 10%. Sadly for 80% of patients, by the time their cancer is diagnosed it has spread to distant organs making them ineligible for potentially curative surgery. Read more
Exploring the transcriptomic and chromatin landscapes of fibroblast-like synoviocytes in rheumatoid arthritis
Genetic studies in rheumatoid arthritis (RA) have been successful in identifying regions of the genome which contribute to disease risk, but it is often unclear which genes they effect. Read more
Modelling immuno-metabolic alterations to characterize disease pathogenesis and progression using single cell and spatial multi 'omic technologies
This studentship aims at using and developing bioinformatic and data modelling skills to explore the metabolic and immunological mechanisms involved in disease pathogenesis of multiple diseases such as Cancer. Read more
A novel computational biomechanics framework to model vascular mechanopropagation and single cell mechanosensing
The mechanical stimuli generated by body exercise can be transmitted from cortical bone into the deep bone marrow. A mechanosensitive perivascular stem cell niche is recently identified within the bone marrow for osteogenesis and lymphopoiesis. Read more
Dynamic cell fate decisions: linking mechanical signals and protein expression dynamics in the developing eye to understand human developmental disorders
Inherited developmental disorders account for much of childhood visual impairment. Development of the eye requires cell fate decisions that balance stem cell proliferation and differentiation. Read more
Understanding B cell development in immunity: age-related changes (Ref. UOS-ASTAR-2023-1)
A healthy immune system has a good balance between making effective immune responses and avoiding autoimmune disease. Unfortunately, this balance is dysregulated with age. Older people are more prone to adverse consequences of infectious disease and cancer incidence increases with age. Read more
Epigenetic regulation of myocardial cell signaling in multiple long-term conditions and frailty
Project Highlights. 1. Epigenetics in cardiovascular disease and frailty. 2. Integration of transcriptomics and chromatin organisation. Read more
Modelling cell-cell interactions in heterogeneous microbial communities
We need to understand microbial communities, whether in the context of drug sensitive and resistant pathogens growing in a human host or the soil organisms critical to global carbon cycling. Read more
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Understanding fibroblast phenotype and immunological function in cancer: targeting strategies to improve immunotherapy
The Experimental Pathology Group offers a PhD studentship in cancer biology, leading to a PhD degree from the University of Southampton. Read more
Machine Learning for classifying and characterising living cell cultures
In collaboration with the Department of Biology at the University of York and the Department of Computer Science at the University of Sheffield, programmable agent-based computational models have been developed to help interpret how populations of cells arise and repair from individual cell:cell interactions. Read more
Modelling the phospho-regulation of cell cycle control
A fully funded PhD Studentship is available to work with Dr Peter Thorpe, Senior Lecturer in Biochemistry, School for Biological and Behavioural Sciences, QMUL, Professor Conrad Bessant, Professor of Bioinformatics, School for Biological and Behavioural Sciences, QMUL, and Oliver Severn, Research Manager, Singer Instruments Ltd. Read more
Dissecting the cell intrinsic and external signals regulating re-epithelisation
Metastasis is a complex multistep process where cancer cells escape from the primary tumour, disseminate thoughout the body, and seed secondary growths at distant sites. Read more
Oncology: Evaluating Photodynamic Therapy in colorectal cancer using patient-derived organoids
Colorectal cancer (CRC) is the 3rd most common cancer worldwide. Surgery is first line treatment and often in adjunct with chemotherapy. Read more
Understanding the gene regulatory landscape of embryonic stem cells and cancer cells
Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity. Read more