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We have 136 single cell PhD Projects, Programmes & Scholarships

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single cell PhD Projects, Programmes & Scholarships

We have 136 single cell PhD Projects, Programmes & Scholarships

High-throughput characterization and engineering of nucleotide synthases for production of nucleoside analogues

Nucleotides are the building blocks of life, modulating diverse processes from protein production to cell signalling. It is therefore unsurprising that synthetic nucleoside analogues have been developed as therapeutics for the treatment of a wide range of diseases including cancers and viral infections. Read more

Combining laser and ultrasound based molecular delivery strategies for enhanced drug delivery

Overview. This project addresses the critical area of delivering therapeutics to the skin. If successful, the approach will have direct and positive consequences for the treatment of a range of skin diseases, but may also be viewed as a more generic means of drug delivery for treating a much wider range of disease. Read more

Structure and function of enzyme complexes involved in post-transcriptional gene regulation

Many proteins in human cells function as part of high molecular weight multi-subunit assemblies. The structure and function of such large molecular machines is often difficult to characterise due to their complexity, low abundance and structural dynamics. Read more

Psychedelic drugs and serotonergic modulation of functional connectivity in neuronal microcircuits

Psychoactive drugs result in profound alterations of our state of consciousness. Well known examples of such drugs are general anaesthetics, in use since mid-19th century, and psychedelics, which are consumed by different societies from times immemorial. Read more

Using microRNA inhibitors to boost GABAergic inhibition as a genetic therapy for epilepsy

Epilepsy is a chronic neurological disease characterised by recurrent spontaneous seizures and cognitive co-morbidities. Current small molecule approaches to treating epilepsy are ineffective in a significant portion of cases, and are associated with substantial adverse effects. Read more

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