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sperm PhD Projects, Programs & Scholarships

We have 11 sperm PhD Projects, Programs & Scholarships

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  The genomics of sperm killing gene drive
  Dr T Price, Prof G Hurst, Prof S Paterson
Applications accepted all year round
Many selfish genetic elements spread rapidly through populations by killing gametes that do not carry them. This fascinating phenomena also has practical applications.
  High Throughput Phenotypic Screening for Drug Discovery in Male Fertility/Infertility
  Dr C Barratt, Dr P Andrews
Applications accepted all year round
Infertility is a significant global problem affecting ~1 in 7, or ~80 million couples (Barratt et al., 2017).
  Electrophysiological changes in ion channels in human haploid and diploid (spermatozoa and lymphocytes) after nanoparticle exposure
  Research Group: Chemistry and Biosciences
  Dr L Shang, Dr M H Brinkworth, Prof D Anderson
Applications accepted all year round
Nanomaterial-mediated delivery represents a promising technique for repro- and geno- toxicology with a potential to improve the safety and efficacy of existing methodologies, including experimental gene therapy and sperm-mediated gene transfer.
  Calcium signalling in in-vitro fertilization
  Dr K Kaouri, Dr TE Woolley
Application Deadline: 1 March 2019
The aim of this project is to capture the complex interplay of Ca2+ signalling and the cytoplasmic spasms in eggs and make advances that could inform future experiments and ultimately clinical practice.
  Epitranscriptomic mechanisms in the maternal to zygotic transition of vertebrate embryos
  Dr M Soller, Prof F Mueller
Applications accepted all year round
Most mRNAs contain modified nucleotides in mRNA, but we know very little about their function (Haussmann et al, 2016, Dezi et al, 2016, Roignant and Soller, 2017).
  Molecular genetic characterization of Drosophila reproductive behaviours for exploitation in insect population control
  Research Group: BBSRC MIBTP
  Dr M Soller
Applications accepted all year round
Female reproductive behaviours in most insects profoundly change after mating leading to rejection of courting males and induction of egg laying.
  Actin-dependent mechanisms of chromosome segregation in mammalian eggs
  Dr B Mogessie
Applications accepted all year round
Every human life starts when an egg is fertilised by a sperm. Fertilisable eggs are produced from oocytes by a specialised form of cell division called meiosis (1).
  Understanding a molecular architecture of the centriole / basal body
  Dr T Ochi
Application Deadline: 31 January 2019
The aim of this PhD project is to determine the molecular assembly mechanism of a structure of the centriole / basal body by a combined approach of structure biology (cryo-EM and X-ray crystallography) and biochemistry in order to understand underlying mechanisms that cause ciliopathies and cancer.
  Climate change and the evolution of insect mating systems
  Dr SJ Cornell, Dr T Price
Applications accepted all year round
The pervasiveness among animal species of polyandry – i.e., females mating with multiple males – perplexes evolutionary biologists, because it is costly to females (e.g.
  Clinical Genetics: De Novo Mutations, Selfish Selection, Mosaicism and Human Disease - developing methods for identification of new genes/molecular pathways subject to selfish selection within the human testis
  Prof A Goriely, Prof A Wilkie
Application Deadline: 26 July 2019
De novo mutations (DNMs) are a significant contributor to human disease, affecting ~1:300 new births. We study the mechanisms by which these spontaneous mutations arise in the first instance, concentrating on the tissue where most of them originate, the human testis.
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