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splicing PhD Projects, Programs & Scholarships

We have 15 splicing PhD Projects, Programs & Scholarships

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  Use of single molecule fluorescence and cryo-EM to study the regulation of RNA splicing
  Prof I C Eperon, Dr A Hudson
Application Deadline: 7 June 2020

Funding Type

PhD Type

One of the biggest challenges in molecular biology is presented by the selection of sites for RNA splicing. We cannot overstate its importance or apparent complexity.
  Detection in cells of protein interactions on pre-mRNA during the regulation of splicing
  Prof I C Eperon, Dr S Cowley
Application Deadline: 7 June 2020

Funding Type

PhD Type

One of the biggest challenges in molecular biology is presented by the selection of sites for RNA splicing. We cannot overstate its importance or apparent complexity.
  Promoter associated non-coding RNA (ncRNA) regulation of MUC5B expression in idiopathic pulmonary fibrosis (Ref: SF20/APP/MOSCHOS1)
  Dr S Moschos
Applications accepted all year round

Funding Type

PhD Type

Idiopathic Pulmonary Fibrosis (IPF) is an ageing-associated, debilitating lung disease that manifests mainly in men over 60 years of age.
  Promoter associated non-coding RNA (paRNA; ncRNA) regulation of MUC5B expression in idiopathic pulmonary fibrosis (IPF) (Ref: SF20/APP/MOSCHOS2)
  Dr S Moschos
Applications accepted all year round

Funding Type

PhD Type

Idiopathic Pulmonary Fibrosis (IPF) is an ageing-associated, debilitating lung disease affecting mainly men over 60 years of age.
  Genome and transcriptome sequencing and functional analysis to find new mutation types in patients with inherited blindness
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Human inherited retinal dystrophies (IRDs) result from mutations in over 200 different genes, many of them first implicated by the Leeds Vision Research Group (eg Panagiotou E et al 2017, AJHG 100:960-968; El-Asrag M et al 2015, 96:948-54).
  The role of matrix interactions in regulating the SPARC family of matricellular proteins.
  Dr N Hill, Dr A Munasinghe
Applications accepted all year round

Funding Type

PhD Type

The SPARC family of matricellular proteins determine the way in which cells respond to their extracellular environment. SPARC family proteins interact with a range of binding partners, including matrix proteins (1).
  Mechanisms of regulating gene expression via selective mRNA transport
  Dr V Wickramasinghe, Prof R. Pearson
Applications accepted all year round

Funding Type

PhD Type

A critical step in the gene expression pathway that is altered in cancer is nuclear export of mRNA. We have demonstrated that mRNA export is not constitutive, but highly selective and can regulate distinct biological processes through poorly understood mechanisms.
  RNA Methylation in normal and malignant blood development
  Dr L. Kats
Applications accepted all year round

Funding Type

PhD Type

As is the case with DNA and histones, RNA can also be modified and indeed more than 100 chemical groups that decorate all four canonical RNA nucleotides have been described.
  Development of gene therapies for muscular dystrophies
  Dr L Popplewell
Applications accepted all year round

Funding Type

PhD Type

The activities in the Popplewell lab focus on the development of pre-clinical gene therapies for neuromuscular diseases, in particular muscular dystrophies based on gene replacement, endonuclease-mediated gene editing, antisense oligonucleotide (AO)-induced exon skipping and gene sliencing.
  Deciphering a novel anti-ageing epigenetic programme
  Dr G Poulin, Prof A Sharrocks
Applications accepted all year round

Funding Type

PhD Type

Over two decades of intense research in the field of epigenetics have produced compelling evidence that chromatin modifications are crucial for processes such as DNA repair, transcription, splicing, mitosis, meiosis, and in the preservation of the epigenetic memory of cells.
  TDP-43 The Key protein for finding a cure for Motor Neurone Disease
  Dr S Antonyuk, Prof S Hasnain
Applications accepted all year round

Funding Type

PhD Type

Motor neurone disease is a progressive, fatal neurological disorder with no known cure. It is characterised by selective loss of motor neurons in the spinal cord and cortex.
  Novel non-coding RNAs in Drug response, DNA Damage and Aging
  Dr A Kanhere
Applications accepted all year round

Funding Type

PhD Type

Background. One of the biggest surprises of human genomic sequencing was the finding that only ~2% of the genome codes for proteins.
  Computational Functional Genomics
  Assoc Prof G Lunter
Application Deadline: 24 July 2020

Funding Type

PhD Type

We are interested in building computational models to understand and predict the functional consequences of mutations in the (human) genome.
  Computational Functional Genomics
  Assoc Prof G Lunter
Application Deadline: 24 July 2020

Funding Type

PhD Type

We are interested in building computational models to understand and predict the functional consequences of mutations in the (human) genome.
  Neuronal Src kinases: oncogenes in brain development?
  Dr G Evans, Dr S Chawla
Application Deadline: 30 June 2020

Funding Type

PhD Type

The challenges of the developing human brain include co-ordinating the birth and migration of 100 billion neurons and the formation of their 1000 trillion synaptic connections.
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