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splicing PhD Projects, Programs & Scholarships

We have 21 splicing PhD Projects, Programs & Scholarships

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  Structural investigation of Sam68-driven transcription/splicing coupling
  Dr C Dominguez, Prof I C Eperon
Application Deadline: 6 January 2019
The identification of 20-25,000 human genes by the human genome project came as a big surprise since the estimated number of human proteins is around 130,000.
  Alternative pre-mRNA splicing
  Prof C W J Smith
Applications accepted all year round
The following is a general statement about ongoing research on alternative splicing in the Smith lab. Specific projects will be available in one or more of these areas.
  Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam
  Dr M Soller
Application Deadline: 20 January 2019
Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response.
  Understanding the role of spliceosome gene mutations in disease
  Dr R O'Keefe, Prof B Newman
Applications accepted all year round
The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made.
  Analysis of mechanisms of pre-mRNA splicing by single molecule fluorescence
  Prof I C Eperon
Applications accepted all year round
Project co-supervised with Dr D. Cherny. Pre-mRNA splicing is highly complex. Over a hundred proteins and several RNA species assemble into dynamic complexes, in a pathway defined by several stable partial complexes.
  Impact of alternative mRNA splicing on the human proteome
  Dr V Wickramasinghe, Prof R. Pearson
Applications accepted all year round
Alternative splicing of RNA transcripts has emerged as a key mechanism for enabling biological complexity within the human genome.
  Computational biology of gene expression: Identification of gene-targets for splicing factors
  Dr O V Makarova, Dr R Schmid
Application Deadline: 6 January 2019
The human genome is heavily populated with introns that interrupt coding sequences. Introns are removed from nascent RNA by splicing machinery.
  EMBLA Project - Alternative splicing, intrinsically disordered regions and higher-order complex formation
  Dr R Weatheritt
Applications accepted all year round
More than 90% of human genes undergo alternative splicing, the process by which multiple, distinct transcript and protein variants are expressed from a single gene (Weatheritt et al., 2016).
  BBSRC MIBTP - Identification of pathways deregulating neuronal ELAV/Hu RNA binding proteins and alternative splicing in neurodegeneration
  Research Group: BBSRC MIBTP
  Dr M Soller, Dr M Tomlinson
Application Deadline: 6 January 2019
ELAV/Hu proteins comprise a family of highly conserved neuronal RNA binding proteins important for the development of the nervous system and for neuronal functions.
  Deciphering the molecular mechanisms of CADM1 alternative splicing
  Prof I C Eperon, Prof P Bradding, Dr C Dominguez
Application Deadline: 6 January 2019
CADM1 is a tumour suppressor silenced in many carcinomas. CADM1 over-expression is also found in adult T cell leukaemia/lymphoma, and promotes tissue invasion and survival.
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