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splicing PhD Projects, Programs & Scholarships

We have 20 splicing PhD Projects, Programs & Scholarships

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  Alternative pre-mRNA splicing
  Prof C W J Smith
Applications accepted all year round
The following is a general statement about ongoing research on alternative splicing in the Smith lab. Specific projects will be available in one or more of these areas.
  Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam
  Dr M Soller
Applications accepted all year round
Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response.
  Understanding the role of spliceosome gene mutations in disease
  Dr R O'Keefe, Prof B Newman
Applications accepted all year round
The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made.
  Analysis of mechanisms of pre-mRNA splicing by single molecule fluorescence
  Prof I C Eperon
Applications accepted all year round
Project co-supervised with Dr D. Cherny. Pre-mRNA splicing is highly complex. Over a hundred proteins and several RNA species assemble into dynamic complexes, in a pathway defined by several stable partial complexes.
  Impact of alternative mRNA splicing on the human proteome
  Dr V Wickramasinghe, Prof R. Pearson
Applications accepted all year round
Alternative splicing of RNA transcripts has emerged as a key mechanism for enabling biological complexity within the human genome.
  EMBLA Project - Alternative splicing, intrinsically disordered regions and membraneless organelles
  Dr R Weatheritt
Applications accepted all year round
More than 90% of human genes undergo alternative splicing, the process by which multiple, distinct transcript and protein variants are expressed from a single gene (Weatheritt et al., 2016).
  BBSRC MIBTP - Identification of pathways deregulating neuronal ELAV/Hu RNA binding proteins and alternative splicing in neurodegeneration
  Research Group: BBSRC MIBTP
  Dr M Soller, Dr M Tomlinson
Applications accepted all year round
ELAV/Hu proteins comprise a family of highly conserved neuronal RNA binding proteins important for the development of the nervous system and for neuronal functions.
  Defining the role of RNA metabolic processes in colorectal cancer development
  Research Group: Edinburgh Cancer Research Centre
  Dr K Myant
Application Deadline: 15 February 2019
This is one of several projects available on a CRUK funded PhD programme at the Cancer Research UK Edinburgh Centre, which is part of the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh.
  Multimerisation of ELAV/Hu proteins – a key mechanism ensuring specificity for RNA recognition in health and disease
  Dr M Soller, Dr T Knowles
Applications accepted all year round
Aims. Determine the structure of the ELAV dodecameric complex bound to target RNA by cryoEM and functionally probe interaction interfaces in vitro and in vivo in transgenic Drosophila models for neurodegeneration and cancer.
  Therapeutic resolution of Myodysplastic Syndrome (MDS)
  Research Group: Pharmacology and Experimental Therapeutics
  Dr T Nasim, Dr K Pors
Applications accepted all year round
Myelodysplastic syndromes (MDS) are the most common adult myeloid malignancy in the UK and it has been estimated that around 8,000 and 40,000 new cases are diagnosed each year in the UK and USA, respectively.
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