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splicing PhD Projects, Programmes & Scholarships

We have 30 splicing PhD Projects, Programmes & Scholarships

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We have 30 splicing PhD Projects, Programmes & Scholarships

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Understanding the role of spliceosome gene mutations in disease

The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made. Read more

Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam

Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response. Read more

How do RNA-binding proteins control splice site selection? A multi-disciplinary approach.

Almost every protein-coding gene in vertebrates can and does express multiple proteins. This is achieved primarily by RNA splicing, which is an essential step in gene expression in mammals and generates incredible diversity. Read more

Analysis how de novo mutations in an RNA splicing regulator change global gene expression patterns

Male infertility is a very widespread medical problem, but the actual biology of normal fertility is very poorly understood. Recently human genetics has identified mutations within genes that are expressed all over the body that cause male infertility. Read more

CTDP1, a phosphatase at the intersection of transcription and DNA repair

Project Highlights. Quick targeted degradation of CTDP1 to investigate its functions in transcription and pre-mRNA splicing. Investigation of CTDP1 phosphatase activity in DNA repair-associated transcription. Read more

MSc by Research: Non-canonical functions of SRSF protein kinase (SRPK) in pluripotent stem cells

The overarching goal of our research is to identify and characterise the protein kinase signalling pathways that control stem cell pluripotency and differentiation and determine how protein kinase signalling is disrupted to cause human developmental disorders. . Read more

China Scholarship Council: Disruptions to SRSF protein kinase (SRPK) signalling in human developmental disorders

The overarching goal of our research is to identify and characterise the protein kinase signalling pathways that control stem cell pluripotency and differentiation, and determine how protein kinase signalling is disrupted to cause human developmental disorders.  . Read more

MSc by Research: Non-canonical functions of SRSF protein kinase (SRPK) in pluripotent stem cells

The overarching goal of our research is to identify and characterise the protein kinase signalling pathways that control stem cell pluripotency and differentiation and determine how protein kinase signalling is disrupted to cause human developmental disorders. Read more

Roles of protein phosphorylation in coupling transcription termination and RNA maturation

Expression of human protein-coding genes is a highly complex procedure requiring the coordination of transcription and co-transcriptional processes, including pre-mRNA splicing and mRNA cleavage and polyadenylation (CPA). Read more

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