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stem PhD Projects, Programs & Scholarships

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  Haematopoietic Stem Cell Biology: Understanding how the normal haematopoietic stem/progenitor hierarchy is disrupted during the development of myeloid malignancies
  Dr A Mead, Dr S Thongjuea, Dr B Psalia
Application Deadline: 26 July 2019
Understanding how the normal haematopoietic stem/progenitor hierarchy is disrupted during the development of myeloid malignancies.
  Profiling stem cell epigenetic transitions within the Drosophila hematopoietic stem cell niche
  Dr P Badenhorst
Applications accepted all year round
The self-renewal and differentiation of stem cells is controlled by signals derived from the microenvironment or “niche”. The paired hematopoietic organs of the Drosophila genetic model organism are a well-characterized system in which the regulation of stem cell behaviour within a niche can be genetically dissected.
  Tissue Engineering of Functional Cardiac Tissue using a Newly Characterised Cardiac Stem Cell Population
  Dr R Oldershaw, Dr R Barrett-Jolley, Dr A P Meeson
Applications accepted all year round
We will develop a novel route to create and test stem cell-derived engineered cardiac tissue for use in heart infarct repair or in vitro drug screening.
  How does amino acid metabolism affect tumour growth?
  Dr L. Cheng
Applications accepted all year round
The effect of diet on tumour growth is hotly debated but poorly characterized. Due to the heterogeneous nature of the tumours, dietary studies in patients with varied genetic background often led to inconclusive outcome.
  Characterizing the heterogeneity of stem cells in the normal breast and breast tumours
  Dr A Ucar, Prof K R Brennan
Applications accepted all year round
Tissue-restricted stem cells are crucial in supporting the development and maintenance of normal tissues. This is also true for tumours, as only a small population of tumour cells, which are known as cancer stem cells, have the unique stemness features and tumour-initiating capacity.
  Integrating mechanical and chemical cues in stem cell migration and differentiation
  Dr P Caswell, Dr J-M Schwartz, Dr J Swift
Applications accepted all year round
Adult stem cells are found in most tissues, and the interaction between stem cells and their niche tightly controls their self-renewal and differentiation state.
  Hematopoietic Stem Cell Genetics: Using single cell biology and genetics to understand how hematopoietic stem cells normally sustain blood formation, and how this process is altered during ageing and when leukemia develops.
  Prof Claus Nerlov, Dr P Vyas
Application Deadline: 26 July 2019
Using single cell biology and genetics to understand how hematopoietic stem cells normally sustain blood formation, and how this process is altered during ageing and when leukemia develops.
  Non-coding RNA regulation of stem cells
  Dr S Brown, Dr P Gokhale
Applications accepted all year round
Stem cells have the potential to make any cell type in the Human body and are powerful tools in drug discovery (Xia and Wong, 2012).
  Regulation of autophagy in human embryonic stem cells and its therapeutic application in induced pluripotent stem cell-based disease models
  Dr S Sarkar
Applications accepted all year round
Project background. Regulation of proteostasis is critical for maintaining tissue homeostasis. Autophagy, a major intracellular degradation pathway essential for cellular and energy homeostasis, functions in the clearance of aggregation-prone proteins and damaged organelles.
  What keeps the gut stem cell niche healthy? (SOBOLEWSKIAU19SF)
  Dr A Sobolewski
Applications accepted all year round
A normal functioning epithelium is vital for a healthy gut. The epithelium forms a protective barrier between the bacteria and food contents in the intestine and the underlying immune system, so preventing an immune response.
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