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stem PhD Projects, Programmes & Scholarships
We have 173 stem PhD Projects, Programmes & Scholarships
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Stem cells and hungry neurons: neuropeptides in energy homeostasis
Summary. You will investigate the role of neural stem cells and neurons in energy homeostasis. You will determine how neuropeptides and diet affects stem cells, neurons and glia from mouse and human brain. Read more
Integrating mechanical and chemical cues in stem cell migration and division
Adult stem cells are found in most tissues, and the interaction between stem cells and their niche tightly controls their self-renewal and differentiation state. Read more
Haematopoietic stem cell dysfunction in ageing and disease
Adult organs are maintained by specialised stem cells that persist throughout life thanks to their ability to make exact copies of themselves, all the time retaining the ability to on demand produce the differentiated component cells of the tissue of which they are a part. Read more
Molecular mechanisms of stem cell function in skeletal muscle ageing
The ability of skeletal muscles to regenerate in response to injury, exercise, growth or disease depends on a population of adult skeletal muscle stem cells. Read more
Targeting lipid signalling pathways to restore the differentiation capacity of aged satellite stem cells
This project investigates the impact of druggable phosphoinositide signalling pathways on the epigenetic status and transcriptional output of muscle satellite stem cells which controls their differentiation. Read more
Stem Cells: Developing pluripotent stem cell models of inherited retinal diseases
Inherited retinal dystrophies are a leading cause of blindness and visual loss in the UK working age population. However, despite the widespread diagnostic use of next-generation sequencing, a molecular genetic diagnosis is unavailable for many patients world-wide. Read more
Studying protein homeostasis in healthy and malignant stem cell development
The Grey lab studies the role of protein homeostasis in healthy and malignant haematopoietic (blood) stem cell development. We focus on the proteome of healthy stem cells as they mature in vivo, expand in vitro and their therapeutic use for bone marrow transplantation. Read more
Basal stem cells in the lung and their recognition of dying cells
Stem cell division and differentiation is critical for barrier repair following inflammation, but the initial trigger for this process is unknown. Read more
Mechanisms of Cancer Stem Cell Survival, Metastasis Formation and Immune Evasion in Cancer
Recent research suggests that cancer cells within a tumour represent a highly heterogeneous cell population. In particular many tumours contain small percentage of cells that share several characteristics with stem cells. Read more
Impact of Inflammatory Signals on the Regenerative, Anti-inflammatory and Immunomodulatory Potential of Human Mesenchymal Stem Cells and their Secretome
Adult multipotent stem cells can be easily isolated from a variety of adult human tissues and organs including bone marrow and adipose tissue. Read more
Harnessing cell competition to boost tissue repopulation in stem cell therapies
Cell competition is a fundamental biological process akin to natural selection at the cellular level. Through this selection process, cells that are relatively less fit, mis-specified or that harbour some oncogenic mutations are eliminated, and hence called losers, when in proximity of fitter cells, termed winners. Read more
Role of primary cilia in skeletal muscle stem cells and muscle regeneration.
Primary cilia are cellular organelles present at the surface of many cell types in vertebrates. In recent years, they have been shown to play essential roles in relaying signalling information from the environment to the cell. Read more
MSc by Research: Monitoring and manipulating kinase activity in stem cells
Posttranslational modifications of proteins are important regulatory events that impact most if not all physiological functions of cells. Read more
Induced pluripotent stem cells (iPSCs) as model systems to study hematological malignancies
Myelodysplastic syndromes (MDS) are a type of blood cancer originating at the level of haematopoietic stem/progenitor cells (HSPCs) and often progress to acute myeloid leukaemia (AML). Read more
MSc by Research: Non-canonical functions of SRSF protein kinase (SRPK) in pluripotent stem cells
The overarching goal of our research is to identify and characterise the protein kinase signalling pathways that control stem cell pluripotency and differentiation and determine how protein kinase signalling is disrupted to cause human developmental disorders. . Read more
