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stem cell therapy PhD Projects, Programs & Scholarships

We have 23 stem cell therapy PhD Projects, Programs & Scholarships

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  Refining haematopoietic stem cell populations and their gene modification as a therapy for rare inherited disorders
  Prof M Malim
Application Deadline: 5 April 2019
Developments from academic and biotech sectors have driven gene and stem cell therapy to the clinical setting, with data demonstrating an encouraging long term safety profile and durable correction of several inherited genetic blood disorders such as ADA-SCID (Strimvelis) and X-CGD (OTL-102).
  Hematopoietic Stem Cell Genetics: Using single cell biology and genetics to understand how hematopoietic stem cells normally sustain blood formation, and how this process is altered during ageing and when leukemia develops.
  Prof Claus Nerlov, Dr P Vyas
Application Deadline: 26 July 2019
Using single cell biology and genetics to understand how hematopoietic stem cells normally sustain blood formation, and how this process is altered during ageing and when leukemia develops.
  Assessing the ability of hypoxic pre-conditioning to enhance the immunomodulatory capacity of canine cardiac stem cell as a bridge to the treatment of dilated cardiomyopathy.
  Dr D Connolly
Applications accepted all year round
Dilated Cardiomyopathy (DCM) is a common and serious disease, which imposes a significant welfare burden in dogs. DCM is particularly well characterise in Dobermans where a 58.8% cumulative prevalence has been identified in European lines.
  Characterizing the heterogeneity of stem cells in the normal breast and breast tumours
  Dr A Ucar, Prof K R Brennan
Applications accepted all year round
Tissue-restricted stem cells are crucial in supporting the development and maintenance of normal tissues. This is also true for tumours, as only a small population of tumour cells, which are known as cancer stem cells, have the unique stemness features and tumour-initiating capacity.
  Targeting The Thymus To Improve Immune Recovery Following Stem Cell Transplantation For Cancer Treatment
  Prof G Anderson, Dr W Jenkinson
Applications accepted all year round
Background. The treatment of cancer frequently requires the transplantation of bone marrow to regenerate the immune system that is damaged following ablative therapy.
  Regulation of autophagy in human embryonic stem cells and its therapeutic application in induced pluripotent stem cell-based disease models
  Dr S Sarkar
Applications accepted all year round
Project background. Regulation of proteostasis is critical for maintaining tissue homeostasis. Autophagy, a major intracellular degradation pathway essential for cellular and energy homeostasis, functions in the clearance of aggregation-prone proteins and damaged organelles.
  The effect of polysialyltransferase modulation on tumour cell migration
  Research Group: Institute of Cancer Therapeutics
  Dr S Shnyder, Dr R Falconer
Applications accepted all year round
One of the main reasons for failure of cancer therapy today is an inability to control tumour dissemination, with secondary tumour deposits the cause of morbidity.
  Engineering the skeletal muscle stem cell niche using microporous tissue engineering constructs
  Dr A G Borycki
Applications accepted all year round
Background. Satellite cells are skeletal muscle stem cells that reside in a specific micro-environment called the niche and are responsible for muscle repair upon injury or diseases.
  Identifying the role of glycosaminoglycans and microglia in early pathology of mucopolysaccharide diseases
  Dr B BIgger, Dr R Holley, Prof S Flitsch
Applications accepted all year round
Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by the deficiency of specific lysosomal enzymes required for the catabolism of glycosaminoglycans (GAGs) where each MPS type lacks a specific enzyme resulting in the build-up of GAGs in all cells of the body.
  Mechanisms of Cancer Stem Cell Survival, Metastasis Formation and Immune Evasion in Cancer
  Dr D Widera
Applications accepted all year round
Recent research suggests that cancer cells within a tumour represent a highly heterogeneous cell population. In particular many tumours contain small percentage of cells that share several characteristics with stem cells.
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