Adult stem cells are found in most tissues, and the interaction between stem cells and their niche tightly controls their self-renewal and differentiation state. Read more
Primary cilia are cellular organelles present at the surface of many cell types in vertebrates. In recent years, they have been shown to play essential roles in relaying signalling information from the environment to the cell. Read more
Background. We recently identified a novel human syndrome caused by mutations in a gene called KMT2C1. Patients with this condition predominantly have developmental delay and intellectual disability indicating the important function of this gene in brain’s normal development and function. Read more
Stem cell division and differentiation is critical for barrier repair following inflammation, but the initial trigger for this process is unknown. Read more
Adult multipotent stem cells can be easily isolated from a variety of adult human tissues and organs including bone marrow and adipose tissue. Read more
Our understanding of cardiac cell development remains incomplete, specifically how the progenitor cells, which give rise to the heart, are programmed to acquire cardiac potential. Read more
Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity. Read more
The ability of skeletal muscles to regenerate in response to injury, exercise, growth or disease depends on a population of adult skeletal muscle stem cells. Read more
Myelodysplastic syndromes (MDS) are a type of blood cancer originating at the level of haematopoietic stem/progenitor cells (HSPCs) and often progress to acute myeloid leukaemia (AML). Read more
The overarching goal of our research is to identify and characterise the protein kinase signalling pathways that control stem cell pluripotency and differentiation and determine how protein kinase signalling is disrupted to cause human developmental disorders. . Read more
Cancer stem cells present a huge clinical problem in cancer relapse due to their stem cell-like characteristics including enhanced self-renewal, migration, and resistance to chemotherapy. Read more
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