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stem cells PhD Projects, Programmes & Scholarships

We have 126 stem cells PhD Projects, Programmes & Scholarships

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We have 126 stem cells PhD Projects, Programmes & Scholarships

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4-year PhD Studentship: Targeting cancer stem cells: Selective culture method and drug search

Cancer stem cells are a small population of cells in tumours maintaining the tumorigenic capacity (1). They are featured as quiescent (i.e., dormant), in contrast to the majority of cancer cells that actively proliferate under the aberrant regulation. Read more

Self funded BMS Project: Understanding the population dynamics of haematopoietic stem cells during gene therapy for sickle cell disease

Applications accepted for PhD Only. Background. This project builds on the recent discovery that whole genome sequencing approaches in blood stem and progenitor cells can be used to estimate the number of actively contributing blood stem cells in humans (Lee-Six et al., Nature 2018). Read more

Regulation of asymmetric cell division in brain cancer stem cells

Glioblastoma is the most lethal brain cancer in adults. Its poor prognosis is a result of aggressive tumour growth, therapeutic resistance, and tumour heterogeneity at the cellular and genetic level. Read more

Role of primary cilia in skeletal muscle stem cells and muscle regeneration.

Primary cilia are cellular organelles present at the surface of many cell types in vertebrates. In recent years, they have been shown to play essential roles in relaying signalling information from the environment to the cell. Read more

An omics approach to understand and treat KMT2C-related neurodevelopmental disorder using induced pluripotent stem cells and CRISPR-Cas9

Background. We recently identified a novel human syndrome caused by mutations in a gene called KMT2C1. Patients with this condition predominantly have developmental delay and intellectual disability indicating the important function of this gene in brain’s normal development and function. Read more

Origins of Genotoxic metabolism and the DNA damage response in stem and cancer cells

Our work has shown that metabolism both generalized and intrinsic to blood stem cells unleashes reactive metabolites such as the aldehydes – formaldehyde and acetaldehyde. Read more

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