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synthetic biology PhD Projects, Programs & Scholarships

We have 192 synthetic biology PhD Projects, Programs & Scholarships

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  Structure and activity of carbohydrate-active enzymes associated with human disease
  Dr L Willems, Prof G Davies
Application Deadline: 1 February 2020

Funding Type

PhD Type

Proteins on the surface of mammalian cells are often modified with diverse, complex carbohydrate structures. These carbohydrates, named glycans, play key roles in a range of cellular processes including cell-cell and host-pathogen interactions.
  Disintegration of protein clearance pathways during ageing: a parallel proteomics approach
  Dr Rahul S Samant
Application Deadline: 3 December 2019

Funding Type

PhD Type

The accumulation of misfolded or otherwise non-native proteins in the cell is linked to an array of ageing-related disorders, including neurodegenerative diseases and cancers1.
  A multidisciplinary approach to target MYC-driven childhood cancers
  Prof E Tate, Prof L Chesler
Application Deadline: 22 November 2019

Funding Type

PhD Type

Synthetic lethality driven by N-myristoyltransferase inhibition. a convergence approach to target MYCN-driven childhood cancers. Short title.
  Taking de novo protein design and assembly into bacterial cells
  Prof DN Woolfson, Prof N J Savery, Prof P Verkade
Application Deadline: 2 December 2019

Funding Type

PhD Type

De novo protein design is said to have come of age (Huang et al., (2016) Nature 537 320). This is because a wide variety of synthetic protein structures can now be made from scratch, i.e., from first principles, or by applying computational design.
  The role of modified microRNAs in fibrosis during ageing
  Dr K Whysall, Prof G Bou-Gharios
Application Deadline: 22 November 2019

Funding Type

PhD Type

MicroRNAs (miRNAs) are small, non-coding RNAs that regulate the expression of multiple mRNAs posttranscriptionally (Brown & Goljanek-Whysall, Aging Res Rev 2015).
  A dynamic biomaterial-ligand tethering strategy for tissue engineering
  Dr C Spicer, Prof D K Smith
Applications accepted all year round

Funding Type

PhD Type

Biomaterials that can trigger the repair of damaged tissues have the potential to revolutionise the way we treat disease. Materials that can present cells and tissues with powerful biochemical signals, through attached peptides, proteins, and carbohydrates, are particularly effective at controlling regeneration.
  The chemical glycobiology of carbohydrate metabolism
  Prof R Field, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Carbohydrates are widespread in nature and fulfil many important biological functions. However, the biology of carbohydrates is much less well explored than that of nucleic acids and proteins.
  Natural toxins and their synthetic analogues as tools to study ion channels and as potential drugs and pesticides
  Dr I R Mellor
Applications accepted all year round

Funding Type

PhD Type

The project will use a combination of electrophysiological techniques such as voltage-clamp and patch-clamp with molecular biology and protein expression to understand how natural toxins and their synthetic analogues act on ion channels in the nervous system.
  The synthetic littermate project: How do natural experiences shape the functional organisation of the developing brain?
  Dr SP Wilson, Prof AJ Prescott
Applications accepted all year round

Funding Type

PhD Type

How do natural experiences shape the functional organisation of the developing brain? To address this question directly, we have been developing a novel robotic technology - the synthetic littermate (or ’surrogate’).
  Bacterial chemical harpoons – how do TIE proteins function?
  Research Group: Biomedical Sciences Research Centre
  Dr U Schwarz-Linek
Application Deadline: 1 December 2019

Funding Type

PhD Type

In order to colonise a host and cause infections, bacteria need to gain a foothold by adhering to tissues such as cell surfaces. In general this is achieved through specific interactions between proteins and multimeric protein assemblies (pili) presented on the bacterial surface, and host molecules.
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