TO APPLY CLICK 'INSTITUTION WEBSITE' . γδ T cells are a rare population of T cell receptor-expressing cells that function like innate immune cells.γδ T cells consist of several different subtypes that can promote or prevent cancer progression, depending on the cytokines and cytotoxic molecules they express. Read more
T cells play critical roles in the host response to viral infection. Activated cytotoxic CD8 T cells are able to kill virally infected cells while… Read more
Upon activation a T cell transitions from a state of semi-quiescence to a state of high activity. During the process of activation the T cell therefore needs to up regulate metabolic pathways to acquire the energy and nutrients required to facilitate the behavioural changes associated with its new functional state. Read more
Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. Read more
Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. Read more
The UCL Myeloma and Tumour Immunology groups are seeking a talented and enthusiastic PhD candidate to lead a project to identify and characterise tumour directed T cells in the bone marrow environment of patients with smouldering myeloma. Smouldering myeloma is a pre-cancerous condition that carries a 50% risk (over 5 years) of developing into the bone marrow cancer called multiple myeloma. Read more
Post summary. As we age, changes occur in the profile of the immune system T cells, resulting in less “young” T cells and more “older”, potential dysfunctional and inflammatory T cells. Read more
Supervisors. Dr Laura Rivino (Bristol, lead supervisor), Dr Edward Wang (Cardiff), Dr Richard Stanton (Cardiff), Prof Nicholas Timpson (Bristol), Dr Sophie Yacoub (Oxford University Clinical Research Unit, HCMC, Vietnam). Read more
Adoptive cell therapy (ACT) using tumour infiltrating lymphocytes (TILs) or genetically redirected T cells are some of the most promising approaches to emerge recently for the treatment of metastatic disease. Read more
Summary. Cytotoxic T cells have the capability of killing tumour target cells. However, this ability is commonly suppressed within the tumour microenvironment. Read more
Since they were first discovered in 2000, the function of T follicular helper (Tfh) cells has been a subject of intense and fast-moving research. It is now clear that these cells are critical in orchestrating the B cell/antibody response and they have become a focus in improving targeted cancer immunotherapy and vaccine strategies. Read more
Harvard T.H. Chan School of Public Health brings together dedicated experts from every discipline to educate new generations of global health leaders and produce powerful ideas that can transform the lives of people everywhere. Read more
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