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We have 310 t PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
t PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
We have 310 t PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships
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Control of mucosal immunity and intestinal integrity by human gamma/delta T cells
Project Summary. γδ T cells are 'unconventional' lymphocytes that promote mucosal barrier defence and regulate immune responses to microbial infection. Read more
MSc By Research: How does ageing shape conventional T cell activation and function?
Immune function in mammalian species, including humans, declines during ageing and is multi-faceted. From a human health perspective, this poses a considerable challenge as people are living for much longer than in previous decades and centuries because of advances in medicine, nutrition, and public health. Read more
Developing Personalised Vaccines – the Next Generation in Vaccine Development (ref: SF22/HLS/APP/ANTONIOU)
The COVID-19 pandemic has seen unprecedented development and employment of new vaccine technologies that can be produced and administered quickly. Read more
Examining How Thymus Stromal Cells Control T Cell Development
We are seeking talented, motivated students with a passion for research in T-cell development and thymus biology to study under the supervision of Dr William Jenkinson. Read more
MSc by Research: Regulation of T cell function by SIK3 in viral infection
T cells play critical roles in the host response to viral infection. Activated cytotoxic CD8 T cells are able to kill virally infected cells while… Read more
Immunotherapy: Manipulating T cell metabolism to improve anti-tumour immunity
The induction of immune responses to tumours can provide long-lasting protection from cancer. In this regard, T cells can suppress tumour growth by directly killing cancer cells and by producing inflammatory cytokines. Read more
MSC BY RESEARCH - Preserving t-tubule function in adult cardiac myocytes in short-term culture
Invaginations of the sarcolemma of adult cardiac myocytes known as transverse (or t-) tubules account for up to 65% of the total sarcolemma surface and play a key role in excitation-contraction (EC) coupling and cell signalling (Hong & Shaw, 2017). Read more
How regulatory immunological cues (re)programme cellular metabolism to control effector T cell behaviour and function
Upon activation a T cell transitions from a state of semi-quiescence to a state of high activity. During the process of activation the T cell therefore needs to up regulate metabolic pathways to acquire the energy and nutrients required to facilitate the behavioural changes associated with its new functional state. Read more
Exploiting tumour-promoting paracrine signals in solid cancers to turbocharge genetically redirected T cells
Adoptive cell therapy (ACT) using tumour infiltrating lymphocytes (TILs) or genetically redirected T cells are some of the most promising approaches to emerge recently for the treatment of metastatic disease. Read more
MSc by Research: Using genome editing to study the mechanisms of immune cell proliferation and differentiation
T lymphocytes mediate long-term adaptive immunity to viruses and tumour cells. T lymphocytes recognize foreign antigens via specific interactions with the T cell receptor (TCR) that is expressed on the cell surface. Read more
Understanding tumour-mediated suppression of cytotoxic T cell function by rebuilding it in vitro
Summary. Cytotoxic T cells have the capability of killing tumour target cells. However, this ability is commonly suppressed within the tumour microenvironment. Read more
Self Funded PhD Project: Studies on the Design, Synthesis and Biological Evaluation of a Novel Bioactive Indane Scaffold
A wide range of bioactive indane based scaffolds are employed clinically as treatment of many disease states, including inflammatory [1], cancer [2] and neurological conditions [3] and also in the treatment of HIV [4]. Read more
Understanding host-pathogen interaction during T. gondii infection using stem cell derived tissue organoids to inform drug therapy development (VC23010)
We are seeking a highly motivated PhD student to study host-pathogen interactions during Toxoplasma gondii infection to inform drug discovery and drug delivery. Read more
Role of T and NK-cell immunity during dengue virus infection and impact of immune modulation during therapy
A PhD position is available to study the role of human T and NK-cell immunity during infection with dengue virus (DENV), a flavivirus that is transmitted by infected Aedes mosquitoes. Read more
Hydrothermal cracking of waste plastic polymers to high-value commodity chemicals
We aim to construct and operate a prototype for continuous conversion of mixed plastic polymers feedstock to naphtha-range chemicals by SCW-hydrocracking (SCWH). Read more